G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

K Labib, J F Diffley, S E Kearsey

ABSTRACT

Cyclin-dependent kinases (CDKs) activate the firing of replication origins during the S phase of the cell cycle. They also block re-initiation of DNA replication within a single cell cycle, by preventing the assembly of prereplicative complexes at origins. We show here that, in budding yeast, CDKs exclude the essential prereplicative-complex component Mcm4 from the nucleus. Although origin firing can be triggered by the B-type cyclins only, both G1-phase and B-type cyclins cause exit of Mcm4 from the nucleus. These results suggest that G1 cyclins may diminish the cell's capacity to assemble prereplicative complexes before B-type cyclins trigger origin firing during S phase. More... »

PAGES

415-422

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/15649

DOI

http://dx.doi.org/10.1038/15649

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039277346

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10559985


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