Meiotic instability of human minisatellite CEB1 in yeast requires DNA double-strand breaks View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Hélène Debrauwère, Jérôme Buard, Jacques Tessier, Dominique Aubert, Gilles Vergnaud, Alain Nicolas

ABSTRACT

Minisatellites are tandemly repeated DNA sequences of 10–100-bp units1. Some minisatellite loci are highly unstable in the human germ line, and structural analysis of mutant alleles has suggested that repeat instability results from a recombination-based process. To provide insights into the molecular mechanism of human minisatellite instability, we developed Saccharomyces cerevisiae strains carrying alleles of the most unstable human minisatellite locus, CEB1 (ref. 2). We observed that CEB1 is destabilized in meiosis, resulting in a variety of intra- and inter-allelic gains or losses of repeat units, similar to rearrangements described in humans3. Using mutations affecting the initiation of recombination4,5 (spo11) or mismatch repair6 (msh2 pms1 ), we demonstrate that meiotic destabilization depends on the initiation of homologous recombination at nearby DNA double-strand break (DSBs) sites and involves a 'rearranged heteroduplex' intermediate. Most of the human and yeast data can be explained and unified in the context of DSB repair models7. More... »

PAGES

367-371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/15557

DOI

http://dx.doi.org/10.1038/15557

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045259535

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10545956


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