Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

Maria Frasson, Jose A. Sahel, Michel Fabre, Manuel Simonutti, Henri Dreyfus, Serge Picaud

ABSTRACT

Retinitis pigmentosa is an inherited degenerative disease of photoreceptors leading to blindness. A well-characterized model for this disease is provided by the retinal degeneration mouse, in which the gene for the rod cGMP phosphodiesterase is mutated, as in some affected human families. We report that D-cis-diltiazem, a calcium-channel blocker that also acts at light-sensitive cGMP-gated channels, rescued photoreceptors and preserved visual function in the retinal degeneration mouse. The long record of diltiazem prescription in cardiology should facilitate the design of clinical trials for some forms of retinitis pigmentosa. More... »

PAGES

1183-1187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/13508

DOI

http://dx.doi.org/10.1038/13508

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048713982

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10502823


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