A universal influenza A vaccine based on the extracellular domain of the M2 protein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

Sabine Neirynck, Tom Deroo, Xavier Saelens, Peter Vanlandschoot, Willy Min Jou, Walter Fiers

ABSTRACT

The antigenic variation of influenza virus represents a major health problem. However, the extracellular domain of the minor, virus-coded M2 protein is nearly invariant in all influenza A strains. We genetically fused this M2 domain to the hepatitis B virus core (HBc) protein to create fusion gene coding for M2HBc; this gene was efficiently expressed in Escherichia coli. Intraperitoneal or intranasal administration of purified M2HBc particles to mice provided 90-100% protection against a lethal virus challenge. The protection was mediated by antibodies, as it was transferable by serum. The enhanced immunogenicity of the M2 extracellular domain exposed on HBc particles allows broad-spectrum, long-lasting protection against influenza A infections. More... »

PAGES

1157

Journal

TITLE

Nature Medicine

ISSUE

10

VOLUME

5

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/13484

    DOI

    http://dx.doi.org/10.1038/13484

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10502819


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