Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10-01

AUTHORS

Marc Ferrer, Tarun M. Kapoor, Tim Strassmaier, Winfried Weissenhorn, John J. Skehel, Dan Oprian, Stuart L. Schreiber, Don C. Wiley, Stephen C. Harrison

ABSTRACT

The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover small organic inhibitors that block gp41 activation, we have generated a biased combinatorial chemical library of non-natural binding elements targeted to the gp41 core. From this library of 61,275 potential ligands, we have identified elements that, when covalently attached to a peptide derived from the gp41 outer-layer alpha-helix, contribute to the formation of a stable complex with the inner core and to inhibition of gp41-mediated cell fusion. More... »

PAGES

nsb1099_953

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/13324

DOI

http://dx.doi.org/10.1038/13324

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009253319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10504731


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combinatorial Chemistry Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Evaluation, Preclinical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp41", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Library", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Secondary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave., Cambridge, Massachusetts 02138, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrer", 
        "givenName": "Marc", 
        "id": "sg:person.01006677654.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006677654.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Chemistry and Chemical Biology, Harvard University, 16 Oxford St., Cambridge, Massachusetts 02138, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kapoor", 
        "givenName": "Tarun M.", 
        "id": "sg:person.01301372564.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301372564.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brandeis University", 
          "id": "https://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Department of Biochemistry, Brandeis University, 415 South St., Waltham, Massachusetts 02454, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strassmaier", 
        "givenName": "Tim", 
        "id": "sg:person.01123126254.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123126254.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Laboratory of Molecular Medicine, The Children's Hospital, 320 Longwood Ave., Boston, Massachusetts 02215, USA.", 
            "Howard Hughes Medical Institute."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weissenhorn", 
        "givenName": "Winfried", 
        "id": "sg:person.01107454075.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107454075.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skehel", 
        "givenName": "John J.", 
        "id": "sg:person.0744102055.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744102055.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brandeis University", 
          "id": "https://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Department of Biochemistry, Brandeis University, 415 South St., Waltham, Massachusetts 02454, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oprian", 
        "givenName": "Dan", 
        "id": "sg:person.012336306534.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012336306534.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Chemistry and Chemical Biology, Harvard University, 16 Oxford St., Cambridge, Massachusetts 02138, USA.", 
            "Howard Hughes Medical Institute."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schreiber", 
        "givenName": "Stuart L.", 
        "id": "sg:person.01106217250.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave., Cambridge, Massachusetts 02138, USA.", 
            "Laboratory of Molecular Medicine, The Children's Hospital, 320 Longwood Ave., Boston, Massachusetts 02215, USA.", 
            "Howard Hughes Medical Institute."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiley", 
        "givenName": "Don C.", 
        "id": "sg:person.01104357451.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357451.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave., Cambridge, Massachusetts 02138, USA.", 
            "Laboratory of Molecular Medicine, The Children's Hospital, 320 Longwood Ave., Boston, Massachusetts 02215, USA.", 
            "Howard Hughes Medical Institute."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrison", 
        "givenName": "Stephen C.", 
        "id": "sg:person.013635370377.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.94.12.6065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008462496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.21.10537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008570940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1998.9532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008762607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387426a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010263645", 
          "https://doi.org/10.1038/387426a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.24.11422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013000742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384179a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017723508", 
          "https://doi.org/10.1038/384179a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.16.9134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019982983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.16.9134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019982983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(86)80010-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021785572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0596-465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021968388", 
          "https://doi.org/10.1038/nsb0596-465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.23.12303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026197098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80460-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029472915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.140.2.315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029979514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384184a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036628325", 
          "https://doi.org/10.1038/384184a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.26.15613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042252386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(85)90157-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042655360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.8.4319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048988991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1295-1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049045339", 
          "https://doi.org/10.1038/nsb1295-1075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.5560070715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053407199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.16.4572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053584460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9600114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053868623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9600114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053868623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00046a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055158637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja953750v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055864093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja953750v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055864093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083163774", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083255223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083345373", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-10-01", 
    "datePublishedReg": "1999-10-01", 
    "description": "The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover small organic inhibitors that block gp41 activation, we have generated a biased combinatorial chemical library of non-natural binding elements targeted to the gp41 core. From this library of 61,275 potential ligands, we have identified elements that, when covalently attached to a peptide derived from the gp41 outer-layer alpha-helix, contribute to the formation of a stable complex with the inner core and to inhibition of gp41-mediated cell fusion.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/13324", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements", 
    "pagination": "nsb1099_953", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2c1459212821fad9a3e4b435126406eb19c62f4f5b0956d95eddf3e61540277c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10504731"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/13324"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009253319"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/13324", 
      "https://app.dimensions.ai/details/publication/pub.1009253319"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nsb1099_953"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/13324'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/13324'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/13324'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/13324'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      73 URIs      40 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/13324 schema:about N00f059510e4a470f8bf3e4666526b3b8
2 N074f2f52ff1c4409924983bb74350cc4
3 N224f2768c8af4500aebfa0c313722fcc
4 N2e414de3b44e4a149b155dbc69cac14e
5 N3151bc5137324c7ab86c2eb87730ec9a
6 N3d5b8abab7a049e9bb7ad92b2947837c
7 N4757a83bc9824231b897557b61b2aee1
8 N5bc62658501848028870060e70a79980
9 N5c650d42d66841929d7ea763169c3e22
10 N6ecf06de4ffc42ee9cbdde22c3001d01
11 N7fe53883993c4450ab64894f1d3875c7
12 N87abb94c47be46aa99c45f56fe8a96a2
13 N96837405b4d443dab05cfd4ebbce5937
14 Na905fe9e8e424315930dfeaacf010828
15 Nac2dfea4b117480386d486cce785a56a
16 Nb04692dfeff949ada66870ea914de580
17 Nb6e662fdf6b8479eb8918c8bcb662afb
18 Ne506a025615f43e8ad96cccaf260dc92
19 Ne950c61435df4856851e00a57f326365
20 Nf3e8997f91c74e27a159554854cb670e
21 anzsrc-for:03
22 anzsrc-for:0305
23 schema:author Nf34bac5b5e8a4905a68781cf42115c69
24 schema:citation sg:pub.10.1038/384179a0
25 sg:pub.10.1038/384184a0
26 sg:pub.10.1038/387426a0
27 sg:pub.10.1038/nsb0596-465
28 sg:pub.10.1038/nsb1295-1075
29 https://app.dimensions.ai/details/publication/pub.1083163774
30 https://app.dimensions.ai/details/publication/pub.1083255223
31 https://app.dimensions.ai/details/publication/pub.1083345373
32 https://doi.org/10.1002/pro.5560070715
33 https://doi.org/10.1006/viro.1998.9532
34 https://doi.org/10.1016/0092-8674(85)90157-6
35 https://doi.org/10.1016/0263-7855(86)80010-8
36 https://doi.org/10.1016/s0092-8674(00)80460-2
37 https://doi.org/10.1021/bi00046a001
38 https://doi.org/10.1021/cr9600114
39 https://doi.org/10.1021/ja953750v
40 https://doi.org/10.1073/pnas.89.21.10537
41 https://doi.org/10.1073/pnas.91.24.11422
42 https://doi.org/10.1073/pnas.94.12.6065
43 https://doi.org/10.1073/pnas.94.23.12303
44 https://doi.org/10.1073/pnas.95.16.9134
45 https://doi.org/10.1073/pnas.95.26.15613
46 https://doi.org/10.1073/pnas.96.8.4319
47 https://doi.org/10.1083/jcb.140.2.315
48 https://doi.org/10.1093/emboj/17.16.4572
49 schema:datePublished 1999-10-01
50 schema:datePublishedReg 1999-10-01
51 schema:description The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover small organic inhibitors that block gp41 activation, we have generated a biased combinatorial chemical library of non-natural binding elements targeted to the gp41 core. From this library of 61,275 potential ligands, we have identified elements that, when covalently attached to a peptide derived from the gp41 outer-layer alpha-helix, contribute to the formation of a stable complex with the inner core and to inhibition of gp41-mediated cell fusion.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N33bcdb3db5eb457d90b924cc7d770332
56 Nd4c6f0a0267c44b1946452308f3436fa
57 sg:journal.1295033
58 schema:name Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements
59 schema:pagination nsb1099_953
60 schema:productId N07b36f2306bf4a45aef8f8143dbfeebd
61 N4a9fc99ea56a433087225d2ad1c2d765
62 Nd7bb9b4fee2348ec9b4417d12cc4885d
63 Ned9d274e35294c2b869f7483102c9ced
64 Nfe19daf46653405fbe7124830f6f2e61
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009253319
66 https://doi.org/10.1038/13324
67 schema:sdDatePublished 2019-04-11T01:46
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N6b3098a90ea14b55b889f6080ccbfbff
70 schema:url http://www.nature.com/articles/nsb1099_953
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N00f059510e4a470f8bf3e4666526b3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name HIV Envelope Protein gp41
76 rdf:type schema:DefinedTerm
77 N074f2f52ff1c4409924983bb74350cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Peptide Fragments
79 rdf:type schema:DefinedTerm
80 N07b36f2306bf4a45aef8f8143dbfeebd schema:name doi
81 schema:value 10.1038/13324
82 rdf:type schema:PropertyValue
83 N224f2768c8af4500aebfa0c313722fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Combinatorial Chemistry Techniques
85 rdf:type schema:DefinedTerm
86 N2e072b7efb724aab81ed4e44b5f1b144 rdf:first sg:person.01123126254.27
87 rdf:rest N5f27602acd054e1d99e821c33fffc4e6
88 N2e414de3b44e4a149b155dbc69cac14e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Peptide Library
90 rdf:type schema:DefinedTerm
91 N3151bc5137324c7ab86c2eb87730ec9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Models, Molecular
93 rdf:type schema:DefinedTerm
94 N33bcdb3db5eb457d90b924cc7d770332 schema:volumeNumber 6
95 rdf:type schema:PublicationVolume
96 N3cbe81de802446ef8740fc098a5073f7 rdf:first sg:person.0744102055.80
97 rdf:rest N74b0ce11ed774627a2fa33156646a032
98 N3d5b8abab7a049e9bb7ad92b2947837c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Protein Binding
100 rdf:type schema:DefinedTerm
101 N4757a83bc9824231b897557b61b2aee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Membrane Fusion
103 rdf:type schema:DefinedTerm
104 N4a9fc99ea56a433087225d2ad1c2d765 schema:name dimensions_id
105 schema:value pub.1009253319
106 rdf:type schema:PropertyValue
107 N5004460ea60546bbb7a04a49f187af4c rdf:first sg:person.01106217250.35
108 rdf:rest N8a25e0625b5a4c34adf0aa9e0c66bba2
109 N5bc62658501848028870060e70a79980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Recombinant Fusion Proteins
111 rdf:type schema:DefinedTerm
112 N5c650d42d66841929d7ea763169c3e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Amino Acid Sequence
114 rdf:type schema:DefinedTerm
115 N5f27602acd054e1d99e821c33fffc4e6 rdf:first sg:person.01107454075.30
116 rdf:rest N3cbe81de802446ef8740fc098a5073f7
117 N6b3098a90ea14b55b889f6080ccbfbff schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N6de0abc8b794423a9472e50683ff104a rdf:first sg:person.013635370377.53
120 rdf:rest rdf:nil
121 N6ecf06de4ffc42ee9cbdde22c3001d01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Drug Design
123 rdf:type schema:DefinedTerm
124 N74b0ce11ed774627a2fa33156646a032 rdf:first sg:person.012336306534.70
125 rdf:rest N5004460ea60546bbb7a04a49f187af4c
126 N7fe53883993c4450ab64894f1d3875c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Ligands
128 rdf:type schema:DefinedTerm
129 N87abb94c47be46aa99c45f56fe8a96a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name HIV-1
131 rdf:type schema:DefinedTerm
132 N8a25e0625b5a4c34adf0aa9e0c66bba2 rdf:first sg:person.01104357451.72
133 rdf:rest N6de0abc8b794423a9472e50683ff104a
134 N96837405b4d443dab05cfd4ebbce5937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Na4f1ca9d56044bf99b4a623d3b7c2bc1 rdf:first sg:person.01301372564.82
138 rdf:rest N2e072b7efb724aab81ed4e44b5f1b144
139 Na905fe9e8e424315930dfeaacf010828 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Fusion
141 rdf:type schema:DefinedTerm
142 Nac2dfea4b117480386d486cce785a56a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Anti-HIV Agents
144 rdf:type schema:DefinedTerm
145 Nb04692dfeff949ada66870ea914de580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Line
147 rdf:type schema:DefinedTerm
148 Nb6e662fdf6b8479eb8918c8bcb662afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Structure, Secondary
150 rdf:type schema:DefinedTerm
151 Nd4c6f0a0267c44b1946452308f3436fa schema:issueNumber 10
152 rdf:type schema:PublicationIssue
153 Nd7bb9b4fee2348ec9b4417d12cc4885d schema:name pubmed_id
154 schema:value 10504731
155 rdf:type schema:PropertyValue
156 Ne506a025615f43e8ad96cccaf260dc92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Drug Evaluation, Preclinical
158 rdf:type schema:DefinedTerm
159 Ne950c61435df4856851e00a57f326365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Dose-Response Relationship, Drug
161 rdf:type schema:DefinedTerm
162 Ned9d274e35294c2b869f7483102c9ced schema:name readcube_id
163 schema:value 2c1459212821fad9a3e4b435126406eb19c62f4f5b0956d95eddf3e61540277c
164 rdf:type schema:PropertyValue
165 Nf34bac5b5e8a4905a68781cf42115c69 rdf:first sg:person.01006677654.64
166 rdf:rest Na4f1ca9d56044bf99b4a623d3b7c2bc1
167 Nf3e8997f91c74e27a159554854cb670e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Molecular Sequence Data
169 rdf:type schema:DefinedTerm
170 Nfe19daf46653405fbe7124830f6f2e61 schema:name nlm_unique_id
171 schema:value 9421566
172 rdf:type schema:PropertyValue
173 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
174 schema:name Chemical Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
177 schema:name Organic Chemistry
178 rdf:type schema:DefinedTerm
179 sg:journal.1295033 schema:issn 1545-9993
180 2331-365X
181 schema:name Nature Structural & Molecular Biology
182 rdf:type schema:Periodical
183 sg:person.01006677654.64 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
184 schema:familyName Ferrer
185 schema:givenName Marc
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006677654.64
187 rdf:type schema:Person
188 sg:person.01104357451.72 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
189 schema:familyName Wiley
190 schema:givenName Don C.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357451.72
192 rdf:type schema:Person
193 sg:person.01106217250.35 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
194 schema:familyName Schreiber
195 schema:givenName Stuart L.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106217250.35
197 rdf:type schema:Person
198 sg:person.01107454075.30 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
199 schema:familyName Weissenhorn
200 schema:givenName Winfried
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107454075.30
202 rdf:type schema:Person
203 sg:person.01123126254.27 schema:affiliation https://www.grid.ac/institutes/grid.253264.4
204 schema:familyName Strassmaier
205 schema:givenName Tim
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123126254.27
207 rdf:type schema:Person
208 sg:person.012336306534.70 schema:affiliation https://www.grid.ac/institutes/grid.253264.4
209 schema:familyName Oprian
210 schema:givenName Dan
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012336306534.70
212 rdf:type schema:Person
213 sg:person.01301372564.82 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
214 schema:familyName Kapoor
215 schema:givenName Tarun M.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301372564.82
217 rdf:type schema:Person
218 sg:person.013635370377.53 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
219 schema:familyName Harrison
220 schema:givenName Stephen C.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53
222 rdf:type schema:Person
223 sg:person.0744102055.80 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
224 schema:familyName Skehel
225 schema:givenName John J.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744102055.80
227 rdf:type schema:Person
228 sg:pub.10.1038/384179a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017723508
229 https://doi.org/10.1038/384179a0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/384184a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036628325
232 https://doi.org/10.1038/384184a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/387426a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010263645
235 https://doi.org/10.1038/387426a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nsb0596-465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021968388
238 https://doi.org/10.1038/nsb0596-465
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nsb1295-1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049045339
241 https://doi.org/10.1038/nsb1295-1075
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1083163774 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1083255223 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1083345373 schema:CreativeWork
246 https://doi.org/10.1002/pro.5560070715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053407199
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1006/viro.1998.9532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008762607
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0092-8674(85)90157-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042655360
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0263-7855(86)80010-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021785572
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0092-8674(00)80460-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029472915
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1021/bi00046a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158637
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1021/cr9600114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053868623
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1021/ja953750v schema:sameAs https://app.dimensions.ai/details/publication/pub.1055864093
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1073/pnas.89.21.10537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008570940
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1073/pnas.91.24.11422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013000742
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1073/pnas.94.12.6065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008462496
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.94.23.12303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026197098
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1073/pnas.95.16.9134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019982983
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1073/pnas.95.26.15613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042252386
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1073/pnas.96.8.4319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048988991
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1083/jcb.140.2.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029979514
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/emboj/17.16.4572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053584460
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.253264.4 schema:alternateName Brandeis University
281 schema:name Department of Biochemistry, Brandeis University, 415 South St., Waltham, Massachusetts 02454, USA.
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
284 schema:name Department of Chemistry and Chemical Biology, Harvard University, 16 Oxford St., Cambridge, Massachusetts 02138, USA.
285 Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave., Cambridge, Massachusetts 02138, USA.
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
288 schema:name Department of Chemistry and Chemical Biology, Harvard University, 16 Oxford St., Cambridge, Massachusetts 02138, USA.
289 Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave., Cambridge, Massachusetts 02138, USA.
290 Howard Hughes Medical Institute.
291 Laboratory of Molecular Medicine, The Children's Hospital, 320 Longwood Ave., Boston, Massachusetts 02215, USA.
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
294 schema:name National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...