MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-09

AUTHORS

Huck-Hui Ng, Yi Zhang, Brian Hendrich, Colin A. Johnson, Bryan M. Turner, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg, Adrian Bird

ABSTRACT

Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of methyl-CpG binding proteins1,2,3,4. The best characterized family member is MeCP2, a transcriptional repressor that recruits histone deacetylases5,6,7. Our report concerns MBD2, which can bind methylated DNA in vivo and in vitro 4 and has been reported to actively demethylate DNA (ref. 8). As DNA methylation causes gene silencing, the MBD2 demethylase is a candidate transcriptional activator. Using specific antibodies, however, we find here that MBD2 in HeLa cells is associated with histone deacetylase (HDAC) in the MeCP1 repressor complex1,9. An affinity-purified HDAC1 corepressor complex10,11 also contains MBD2, suggesting that MeCP1 corresponds to a fraction of this complex. Exogenous MBD2 represses transcription in a transient assay, and repression can be relieved by the deacetylase inhibitor trichostatin A (TSA; ref. 12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes. More... »

PAGES

58-61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/12659

DOI

http://dx.doi.org/10.1038/12659

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024638800

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10471499


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxamic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sin3 Histone Deacetylase and Corepressor Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptional Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK", 
          "id": "http://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Huck-Hui", 
        "id": "sg:person.01045445075.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045445075.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yi", 
        "id": "sg:person.015533713660.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015533713660.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK", 
          "id": "http://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hendrich", 
        "givenName": "Brian", 
        "id": "sg:person.01355477547.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355477547.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Colin A.", 
        "id": "sg:person.01005163542.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005163542.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Bryan M.", 
        "id": "sg:person.0735235766.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735235766.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erdjument-Bromage", 
        "givenName": "Hediye", 
        "id": "sg:person.01260125310.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260125310.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tempst", 
        "givenName": "Paul", 
        "id": "sg:person.01326240510.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326240510.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinberg", 
        "givenName": "Danny", 
        "id": "sg:person.0672601630.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK", 
          "id": "http://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bird", 
        "givenName": "Adrian", 
        "id": "sg:person.0617072514.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617072514.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/5047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020518662", 
          "https://doi.org/10.1038/5047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027172656", 
          "https://doi.org/10.1038/561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0797-256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050969596", 
          "https://doi.org/10.1038/ng0797-256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045988789", 
          "https://doi.org/10.1038/35410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/30764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005546919", 
          "https://doi.org/10.1038/30764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/29680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010577450", 
          "https://doi.org/10.1038/29680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025612017", 
          "https://doi.org/10.1038/35404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031395169", 
          "https://doi.org/10.1038/17533"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-09", 
    "datePublishedReg": "1999-09-01", 
    "description": "Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of methyl-CpG binding proteins1,2,3,4. The best characterized family member is MeCP2, a transcriptional repressor that recruits histone deacetylases5,6,7. Our report concerns MBD2, which can bind methylated DNA in vivo and in vitro 4 and has been reported to actively demethylate DNA (ref. 8). As DNA methylation causes gene silencing, the MBD2 demethylase is a candidate transcriptional activator. Using specific antibodies, however, we find here that MBD2 in HeLa cells is associated with histone deacetylase (HDAC) in the MeCP1 repressor complex1,9. An affinity-purified HDAC1 corepressor complex10,11 also contains MBD2, suggesting that MeCP1 corresponds to a fraction of this complex. Exogenous MBD2 represses transcription in a transient assay, and repression can be relieved by the deacetylase inhibitor trichostatin A (TSA; ref. 12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/12659", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "transcriptional repressor", 
      "histone deacetylase", 
      "histone deacetylase complex", 
      "deacetylase inhibitor trichostatin A", 
      "HeLa cells", 
      "candidate transcriptional activators", 
      "inhibitor trichostatin A", 
      "deacetylase complex", 
      "transcriptional activator", 
      "transient assays", 
      "mammalian DNA", 
      "DNA methylation", 
      "methyl-CpG", 
      "MBD2", 
      "trichostatin A", 
      "biological consequences", 
      "repressor", 
      "DNA", 
      "MeCP2", 
      "genes", 
      "methylation", 
      "alternative pathway", 
      "family members", 
      "MeCP1", 
      "corepressor", 
      "histones", 
      "cells", 
      "specific antibodies", 
      "transcription", 
      "repression", 
      "complexes", 
      "deacetylase", 
      "activator", 
      "demethylase", 
      "pathway", 
      "CpG", 
      "assays", 
      "family", 
      "vivo", 
      "members", 
      "antibodies", 
      "consequences", 
      "fraction", 
      "data", 
      "report", 
      "hand", 
      "MBD2 demethylase", 
      "MeCP1 repressor", 
      "affinity-purified HDAC1 corepressor", 
      "HDAC1 corepressor", 
      "Exogenous MBD2", 
      "methylation-dependent repressor MeCP2", 
      "repressor MeCP2", 
      "MeCP1 histone deacetylase complex"
    ], 
    "name": "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex", 
    "pagination": "58-61", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024638800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/12659"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10471499"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/12659", 
      "https://app.dimensions.ai/details/publication/pub.1024638800"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_324.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/12659"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/12659'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/12659'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/12659'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/12659'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      22 PREDICATES      111 URIs      94 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/12659 schema:about N28689fa0581040149a96e618192bdd3c
2 N2f568fc4f65b4549a95564311a6fb077
3 N55034b944e1f4b80867abd6131cb1073
4 N67d31f9f0cdf4bb2a31de41f2314cff5
5 N6a6eb23e8a90453c9af8a55f0d5f9711
6 N7c42766845e5418c844bf8d585ac6065
7 N7f689a56fe9b4dd599eee3aa9e61a6fb
8 N84057725cbf848fab4d5bf6ad2ac379e
9 N85a355127c2b4d428d229e195d5674b4
10 N875f9e7924eb438e9519b2180658210c
11 N9b8dac4133624beab96ef118c8cf9a13
12 Nb4edecf749cf4c2b85a215bbd53277c6
13 Nbed7d5e66f75492094dd63a0c94bee22
14 Nc211c50d98cc4ea5a21d02895bbdb8e0
15 Nc29a4c2c150b46c09b49c60bc8ab96a8
16 Nd75f2d5f38d043f99da2d9e809c7e3b7
17 Ndaf7d82d7bc34646b1a98bfdd806dcd9
18 Ne021483579da457abd70965d73ca2b6d
19 Ne1a82c4291d94958915b8a01d1676d97
20 Ne5e44518fe7a4839af823a8816212772
21 Nf9a3e949e46c4cb9b58859dd3c55c293
22 anzsrc-for:06
23 anzsrc-for:0601
24 anzsrc-for:0604
25 schema:author N65406783e8fa442792a8dfb1c9f1bf20
26 schema:citation sg:pub.10.1038/17533
27 sg:pub.10.1038/29680
28 sg:pub.10.1038/30764
29 sg:pub.10.1038/35404
30 sg:pub.10.1038/35410
31 sg:pub.10.1038/5047
32 sg:pub.10.1038/561
33 sg:pub.10.1038/ng0797-256
34 schema:datePublished 1999-09
35 schema:datePublishedReg 1999-09-01
36 schema:description Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of methyl-CpG binding proteins1,2,3,4. The best characterized family member is MeCP2, a transcriptional repressor that recruits histone deacetylases5,6,7. Our report concerns MBD2, which can bind methylated DNA in vivo and in vitro 4 and has been reported to actively demethylate DNA (ref. 8). As DNA methylation causes gene silencing, the MBD2 demethylase is a candidate transcriptional activator. Using specific antibodies, however, we find here that MBD2 in HeLa cells is associated with histone deacetylase (HDAC) in the MeCP1 repressor complex1,9. An affinity-purified HDAC1 corepressor complex10,11 also contains MBD2, suggesting that MeCP1 corresponds to a fraction of this complex. Exogenous MBD2 represses transcription in a transient assay, and repression can be relieved by the deacetylase inhibitor trichostatin A (TSA; ref. 12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes.
37 schema:genre article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N18c92069379547779b037c5af8fa4ce6
41 N7b8d2106794f4653b9e31c292817fe02
42 sg:journal.1103138
43 schema:keywords CpG
44 DNA
45 DNA methylation
46 Exogenous MBD2
47 HDAC1 corepressor
48 HeLa cells
49 MBD2
50 MBD2 demethylase
51 MeCP1
52 MeCP1 histone deacetylase complex
53 MeCP1 repressor
54 MeCP2
55 activator
56 affinity-purified HDAC1 corepressor
57 alternative pathway
58 antibodies
59 assays
60 biological consequences
61 candidate transcriptional activators
62 cells
63 complexes
64 consequences
65 corepressor
66 data
67 deacetylase
68 deacetylase complex
69 deacetylase inhibitor trichostatin A
70 demethylase
71 family
72 family members
73 fraction
74 genes
75 hand
76 histone deacetylase
77 histone deacetylase complex
78 histones
79 inhibitor trichostatin A
80 mammalian DNA
81 members
82 methyl-CpG
83 methylation
84 methylation-dependent repressor MeCP2
85 pathway
86 report
87 repression
88 repressor
89 repressor MeCP2
90 specific antibodies
91 transcription
92 transcriptional activator
93 transcriptional repressor
94 transient assays
95 trichostatin A
96 vivo
97 schema:name MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
98 schema:pagination 58-61
99 schema:productId N64e1d516a02c42a2ad35c7dfc4375004
100 Nba7fff5ceea7415aad0473390695a834
101 Ne93147db6fd04f0d8cf934abf8532c0b
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024638800
103 https://doi.org/10.1038/12659
104 schema:sdDatePublished 2021-11-01T18:04
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N6adcdfc40fa64b229d5dab0a1ec5c69b
107 schema:url https://doi.org/10.1038/12659
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N18abe64653f14b79a841b69f0cf5189e rdf:first sg:person.0735235766.69
112 rdf:rest N76d54ddc73374df1b6f6d61bde0b8277
113 N18c92069379547779b037c5af8fa4ce6 schema:issueNumber 1
114 rdf:type schema:PublicationIssue
115 N28689fa0581040149a96e618192bdd3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Recombinant Proteins
117 rdf:type schema:DefinedTerm
118 N2f568fc4f65b4549a95564311a6fb077 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice
120 rdf:type schema:DefinedTerm
121 N4095cd3cfdb446478e68fbff67231fa6 rdf:first sg:person.01005163542.72
122 rdf:rest N18abe64653f14b79a841b69f0cf5189e
123 N55034b944e1f4b80867abd6131cb1073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Sin3 Histone Deacetylase and Corepressor Complex
125 rdf:type schema:DefinedTerm
126 N59b135b8da634ee6acc8d099b6c81e9c rdf:first sg:person.0672601630.11
127 rdf:rest Nc1f328a3332b495ebe3bf8fa9610b744
128 N64e1d516a02c42a2ad35c7dfc4375004 schema:name pubmed_id
129 schema:value 10471499
130 rdf:type schema:PropertyValue
131 N65406783e8fa442792a8dfb1c9f1bf20 rdf:first sg:person.01045445075.21
132 rdf:rest Nf55bb579da0c45229819afcda585c10f
133 N67d31f9f0cdf4bb2a31de41f2314cff5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name DNA-Binding Proteins
135 rdf:type schema:DefinedTerm
136 N6a6eb23e8a90453c9af8a55f0d5f9711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Transfection
138 rdf:type schema:DefinedTerm
139 N6adcdfc40fa64b229d5dab0a1ec5c69b schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N76d54ddc73374df1b6f6d61bde0b8277 rdf:first sg:person.01260125310.62
142 rdf:rest Nc0b3846745724743ab9f86733f8b1091
143 N7b8d2106794f4653b9e31c292817fe02 schema:volumeNumber 23
144 rdf:type schema:PublicationVolume
145 N7c42766845e5418c844bf8d585ac6065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 N7f689a56fe9b4dd599eee3aa9e61a6fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Rats
150 rdf:type schema:DefinedTerm
151 N84057725cbf848fab4d5bf6ad2ac379e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Histone Deacetylases
153 rdf:type schema:DefinedTerm
154 N85a355127c2b4d428d229e195d5674b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Models, Genetic
156 rdf:type schema:DefinedTerm
157 N875f9e7924eb438e9519b2180658210c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Enzyme Inhibitors
159 rdf:type schema:DefinedTerm
160 N9b8dac4133624beab96ef118c8cf9a13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Molecular Sequence Data
162 rdf:type schema:DefinedTerm
163 Nacf211295d0c46e8861157d957d0a1a4 rdf:first sg:person.01355477547.03
164 rdf:rest N4095cd3cfdb446478e68fbff67231fa6
165 Nb4edecf749cf4c2b85a215bbd53277c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Transcriptional Activation
167 rdf:type schema:DefinedTerm
168 Nba7fff5ceea7415aad0473390695a834 schema:name dimensions_id
169 schema:value pub.1024638800
170 rdf:type schema:PropertyValue
171 Nbed7d5e66f75492094dd63a0c94bee22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Hydroxamic Acids
173 rdf:type schema:DefinedTerm
174 Nc0b3846745724743ab9f86733f8b1091 rdf:first sg:person.01326240510.52
175 rdf:rest N59b135b8da634ee6acc8d099b6c81e9c
176 Nc1f328a3332b495ebe3bf8fa9610b744 rdf:first sg:person.0617072514.31
177 rdf:rest rdf:nil
178 Nc211c50d98cc4ea5a21d02895bbdb8e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transcription, Genetic
180 rdf:type schema:DefinedTerm
181 Nc29a4c2c150b46c09b49c60bc8ab96a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name DNA Methylation
183 rdf:type schema:DefinedTerm
184 Nd75f2d5f38d043f99da2d9e809c7e3b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Repressor Proteins
186 rdf:type schema:DefinedTerm
187 Ndaf7d82d7bc34646b1a98bfdd806dcd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Animals
189 rdf:type schema:DefinedTerm
190 Ne021483579da457abd70965d73ca2b6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Brain
192 rdf:type schema:DefinedTerm
193 Ne1a82c4291d94958915b8a01d1676d97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name HeLa Cells
195 rdf:type schema:DefinedTerm
196 Ne5e44518fe7a4839af823a8816212772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Base Sequence
198 rdf:type schema:DefinedTerm
199 Ne93147db6fd04f0d8cf934abf8532c0b schema:name doi
200 schema:value 10.1038/12659
201 rdf:type schema:PropertyValue
202 Nf55bb579da0c45229819afcda585c10f rdf:first sg:person.015533713660.59
203 rdf:rest Nacf211295d0c46e8861157d957d0a1a4
204 Nf9a3e949e46c4cb9b58859dd3c55c293 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Amino Acid Sequence
206 rdf:type schema:DefinedTerm
207 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biological Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
211 schema:name Biochemistry and Cell Biology
212 rdf:type schema:DefinedTerm
213 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
214 schema:name Genetics
215 rdf:type schema:DefinedTerm
216 sg:journal.1103138 schema:issn 1061-4036
217 1546-1718
218 schema:name Nature Genetics
219 schema:publisher Springer Nature
220 rdf:type schema:Periodical
221 sg:person.01005163542.72 schema:affiliation grid-institutes:grid.6572.6
222 schema:familyName Johnson
223 schema:givenName Colin A.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005163542.72
225 rdf:type schema:Person
226 sg:person.01045445075.21 schema:affiliation grid-institutes:grid.4305.2
227 schema:familyName Ng
228 schema:givenName Huck-Hui
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045445075.21
230 rdf:type schema:Person
231 sg:person.01260125310.62 schema:affiliation grid-institutes:grid.51462.34
232 schema:familyName Erdjument-Bromage
233 schema:givenName Hediye
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260125310.62
235 rdf:type schema:Person
236 sg:person.01326240510.52 schema:affiliation grid-institutes:grid.51462.34
237 schema:familyName Tempst
238 schema:givenName Paul
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326240510.52
240 rdf:type schema:Person
241 sg:person.01355477547.03 schema:affiliation grid-institutes:grid.4305.2
242 schema:familyName Hendrich
243 schema:givenName Brian
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355477547.03
245 rdf:type schema:Person
246 sg:person.015533713660.59 schema:affiliation grid-institutes:grid.430387.b
247 schema:familyName Zhang
248 schema:givenName Yi
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015533713660.59
250 rdf:type schema:Person
251 sg:person.0617072514.31 schema:affiliation grid-institutes:grid.4305.2
252 schema:familyName Bird
253 schema:givenName Adrian
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617072514.31
255 rdf:type schema:Person
256 sg:person.0672601630.11 schema:affiliation grid-institutes:grid.430387.b
257 schema:familyName Reinberg
258 schema:givenName Danny
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11
260 rdf:type schema:Person
261 sg:person.0735235766.69 schema:affiliation grid-institutes:grid.6572.6
262 schema:familyName Turner
263 schema:givenName Bryan M.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735235766.69
265 rdf:type schema:Person
266 sg:pub.10.1038/17533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031395169
267 https://doi.org/10.1038/17533
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/29680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010577450
270 https://doi.org/10.1038/29680
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/30764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005546919
273 https://doi.org/10.1038/30764
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/35404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025612017
276 https://doi.org/10.1038/35404
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/35410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045988789
279 https://doi.org/10.1038/35410
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/5047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020518662
282 https://doi.org/10.1038/5047
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027172656
285 https://doi.org/10.1038/561
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/ng0797-256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050969596
288 https://doi.org/10.1038/ng0797-256
289 rdf:type schema:CreativeWork
290 grid-institutes:grid.430387.b schema:alternateName Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA
291 schema:name Division of Nucleic Acids Enzymology, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 08854, Piscataway, New Jersey, USA
292 rdf:type schema:Organization
293 grid-institutes:grid.4305.2 schema:alternateName Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK
294 schema:name Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, EH9 3JR, Edinburgh, UK
295 rdf:type schema:Organization
296 grid-institutes:grid.51462.34 schema:alternateName Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA
297 schema:name Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA
298 rdf:type schema:Organization
299 grid-institutes:grid.6572.6 schema:alternateName Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK
300 schema:name Department of Anatomy, The Medical School, University of Birmingham, B15 2TT, Birmingham, UK
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...