An association between viral genes and human oncogenic alterations: The adenovirus E1A induces the Ewing tumor fusion transcript EWS–FLI1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-09

AUTHORS

Ricardo Sanchez-Prieto, Enrique de Alava, Teresa Palomino, Juan Guinea, Victor Fernandez, Silvia Cebrian, Matilde LLeonart, Pablo Cabello, Pilar Martin, Carlos San Roman, Rafael Bornstein, Javier Pardo, Ana Martinez, Fernando Diaz-Espada, Yve Barrios, Santiago Ramon y Cajal

ABSTRACT

Malignant transformation of human cells requires the accumulation of multiple genetic alterations, such as the activation of oncogenes and loss of function of tumor suppressor genes or those related to genomic instability. Among the genetic alterations most frequently found in human tumors are chromosomal translocations that may result in the expression of chimeric products with transforming capability or are able to change the expression of oncogenes. We show here that the adenovirus early region 1A (E1A) gene can induce a specific human fusion transcript (EWS-FLI1) that is characteristic of Ewing tumors. This fusion transcript was detected by RT-PCR in normal human fibroblasts and keratinocytes after expression of the adenovirus E1A gene, as well as in human cell lines immortalized by adenoviruses. Cloning and sequencing of the RT-PCR product showed fusion points between EWS and FLI1 cDNA identical to those detected in Ewing tumors. In addition, we detected a chimeric protein by western blot analysis and immunoprecipitation and a t(11,22) by fluorescent in situ hybridization. This association between a single viral gene and a specific human fusion transcript indicates a direct link between viral genes and chromosome translocations, one of the hallmarks of many human tumors. More... »

PAGES

nm0999_1076

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/12516

DOI

http://dx.doi.org/10.1038/12516

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049678532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10470089


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/12516'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/12516'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/12516'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/12516'


 

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328 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
329 schema:name Department of Immunology, Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
330 Department of Pathology, Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
331 rdf:type schema:Organization
 




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