Pten is essential for embryonic development and tumour suppression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

A Di Cristofano, B Pesce, C Cordon-Cardo, P P Pandolfi

ABSTRACT

The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers. PTEN germline mutations are found in three related human autosomal dominant disorders, Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), characterized by tumour susceptibility and developmental defects. To examine the role of PTEN in ontogenesis and tumour suppression, we disrupted mouse Pten by homologous recombination. Pten inactivation resulted in early embryonic lethality. Pten-/- ES cells formed aberrant embryoid bodies and displayed an altered ability to differentiate into endodermal, ectodermal and mesodermal derivatives. Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hyperplastic-dysplastic changes in the prostate, skin and colon, which are characteristic of CD, LDD and BZS. They also spontaneously developed germ cell, gonadostromal, thyroid and colon tumours. In addition, Pten inactivation enhanced the ability of ES cells to generate tumours in nude and syngeneic mice, due to increased anchorage-independent growth and aberrant differentiation. These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development. More... »

PAGES

348-355

Journal

TITLE

Nature Genetics

ISSUE

4

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/1235

DOI

http://dx.doi.org/10.1038/1235

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033843315

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9697695


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic and Fetal Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Lethal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ-Line Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hamartoma Syndrome, Multiple", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoric Monoester Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Teratocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testicular Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, NY 10021, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Cristofano", 
        "givenName": "A", 
        "id": "sg:person.0606367352.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606367352.90"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pesce", 
        "givenName": "B", 
        "type": "Person"
      }, 
      {
        "familyName": "Cordon-Cardo", 
        "givenName": "C", 
        "id": "sg:person.01104343103.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104343103.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pandolfi", 
        "givenName": "P P", 
        "id": "sg:person.01355745464.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355745464.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90011-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002324347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.17.2105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003744681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199801)21:1<61::aid-gcc8>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004328406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006330923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0395-249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006649779", 
          "https://doi.org/10.1038/ng0395-249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0597-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875378", 
          "https://doi.org/10.1038/ng0597-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(76)80397-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008632040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5308.1943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014605015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1295-1043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018709271", 
          "https://doi.org/10.1038/nsb1295-1043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.31.6.458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025578929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1994.1496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026080794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1994.1331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026611733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028012299", 
          "https://doi.org/10.1038/31008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028012299", 
          "https://doi.org/10.1038/31008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.8.1383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028976609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/7.3.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031502567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90169-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031566912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1994.1336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036252265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81079-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037997315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90646-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039136966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410290511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042169010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.1.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042750690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.20.2466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043002304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045674792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320440309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046091300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320440309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046091300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(93)25057-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047671222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0497-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048219802", 
          "https://doi.org/10.1038/ng0497-356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0497-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048219802", 
          "https://doi.org/10.1038/ng0497-356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00690290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049917070", 
          "https://doi.org/10.1007/bf00690290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81132-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051679530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.1.473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052782342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.23.12479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053661834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/301659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058609271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5366.1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5366.1086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5369.1614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080020802", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080802476", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082741025", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082884249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083134687", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083143224", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083167108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083195929", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083202724", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-08", 
    "datePublishedReg": "1998-08-01", 
    "description": "The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers. PTEN germline mutations are found in three related human autosomal dominant disorders, Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), characterized by tumour susceptibility and developmental defects. To examine the role of PTEN in ontogenesis and tumour suppression, we disrupted mouse Pten by homologous recombination. Pten inactivation resulted in early embryonic lethality. Pten-/- ES cells formed aberrant embryoid bodies and displayed an altered ability to differentiate into endodermal, ectodermal and mesodermal derivatives. Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hyperplastic-dysplastic changes in the prostate, skin and colon, which are characteristic of CD, LDD and BZS. They also spontaneously developed germ cell, gonadostromal, thyroid and colon tumours. In addition, Pten inactivation enhanced the ability of ES cells to generate tumours in nude and syngeneic mice, due to increased anchorage-independent growth and aberrant differentiation. These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/1235", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Pten is essential for embryonic development and tumour suppression", 
    "pagination": "348-355", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a138315ae9706e4094dcaa772babd0606ba4830b234dfb4af3958b0522ad37c6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9697695"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/1235"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033843315"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/1235", 
      "https://app.dimensions.ai/details/publication/pub.1033843315"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v19/n4/full/ng0898_348.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/1235'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/1235'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/1235'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/1235'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      96 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/1235 schema:about N08cca523b20545448c56576f8be0ddad
2 N0a12a006ae7d485a9cf2c14546fe41dd
3 N21a23cf3314741d6b7fa1cc3991dd99f
4 N28f5ec32353f4721a445bc3dba51d311
5 N2bfde9b8112a4f10b9eb2bfa402bd3e6
6 N2e4f499e9cdf46caa0000542bedcca26
7 N35d30fd91640475ab81e79a89fa4a965
8 N414a23089b874b33a70659fd2fe4396c
9 N44c2fcd6b8dd46ce87981b646cacc65d
10 N4513c9666f224460aae09d072f94e7d5
11 N4c2b523c3b0243ccb86ea6d5241939b6
12 N519d905bfe754c3082835e0f7bb696c4
13 N5c0e2fb278154189bc3488c1058099b6
14 N607389d0be3142dc9ad493b286fa3af0
15 N86da03fc376c41ee8ed7e6c651687dc6
16 N8c746fdb36694f32bf15ea08379c482a
17 N90defcdd00bf4afcb9efc6ada5cf70f3
18 N91b80cfdeb3e4e4a878d8761383e694c
19 N938f467f695e435d8c1babd1e2f0a68c
20 Nb91e613fee0d4e069a5a1a8d5bd62719
21 Nbd6dd73f0d8748cab97082832586392a
22 Nc3a3d5a6c6ac458b888813a5e3d44ee5
23 Nd29b3051a26940c5a045dca41bee602f
24 Nde10500567fa463aa1ef29b531e8ee38
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author N63d5b52acf4b46199bb66f925620d425
28 schema:citation sg:pub.10.1007/bf00690290
29 sg:pub.10.1038/31008
30 sg:pub.10.1038/ng0395-249
31 sg:pub.10.1038/ng0497-356
32 sg:pub.10.1038/ng0597-64
33 sg:pub.10.1038/nsb1295-1043
34 https://app.dimensions.ai/details/publication/pub.1080020802
35 https://app.dimensions.ai/details/publication/pub.1080802476
36 https://app.dimensions.ai/details/publication/pub.1082741025
37 https://app.dimensions.ai/details/publication/pub.1082884249
38 https://app.dimensions.ai/details/publication/pub.1083134687
39 https://app.dimensions.ai/details/publication/pub.1083143224
40 https://app.dimensions.ai/details/publication/pub.1083167108
41 https://app.dimensions.ai/details/publication/pub.1083195929
42 https://app.dimensions.ai/details/publication/pub.1083202724
43 https://doi.org/10.1002/(sici)1098-2264(199801)21:1<61::aid-gcc8>3.0.co;2-6
44 https://doi.org/10.1002/ajmg.1320440309
45 https://doi.org/10.1002/ana.410290511
46 https://doi.org/10.1006/excr.1994.1331
47 https://doi.org/10.1006/geno.1994.1336
48 https://doi.org/10.1006/geno.1994.1496
49 https://doi.org/10.1016/0076-6879(93)25057-9
50 https://doi.org/10.1016/0092-8674(87)90646-5
51 https://doi.org/10.1016/0092-8674(91)90011-m
52 https://doi.org/10.1016/0092-8674(95)90169-8
53 https://doi.org/10.1016/s0022-3476(76)80397-6
54 https://doi.org/10.1016/s0092-8674(00)81079-x
55 https://doi.org/10.1016/s0092-8674(00)81132-0
56 https://doi.org/10.1073/pnas.94.23.12479
57 https://doi.org/10.1073/pnas.95.9.5246
58 https://doi.org/10.1086/301659
59 https://doi.org/10.1093/hmg/6.8.1383
60 https://doi.org/10.1093/hmg/7.3.507
61 https://doi.org/10.1101/gad.12.1.107
62 https://doi.org/10.1101/gad.8.20.2466
63 https://doi.org/10.1101/gad.9.17.2105
64 https://doi.org/10.1126/science.275.5308.1943
65 https://doi.org/10.1126/science.280.5366.1036
66 https://doi.org/10.1126/science.280.5366.1086
67 https://doi.org/10.1126/science.280.5369.1614
68 https://doi.org/10.1128/mcb.13.1.473
69 https://doi.org/10.1136/jmg.31.6.458
70 https://doi.org/10.1172/jci119613
71 schema:datePublished 1998-08
72 schema:datePublishedReg 1998-08-01
73 schema:description The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers. PTEN germline mutations are found in three related human autosomal dominant disorders, Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), characterized by tumour susceptibility and developmental defects. To examine the role of PTEN in ontogenesis and tumour suppression, we disrupted mouse Pten by homologous recombination. Pten inactivation resulted in early embryonic lethality. Pten-/- ES cells formed aberrant embryoid bodies and displayed an altered ability to differentiate into endodermal, ectodermal and mesodermal derivatives. Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hyperplastic-dysplastic changes in the prostate, skin and colon, which are characteristic of CD, LDD and BZS. They also spontaneously developed germ cell, gonadostromal, thyroid and colon tumours. In addition, Pten inactivation enhanced the ability of ES cells to generate tumours in nude and syngeneic mice, due to increased anchorage-independent growth and aberrant differentiation. These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N7180a5d614df4d638eaa0b39c043a852
78 Nae12a55bb3be4a80acef60af237816f1
79 sg:journal.1103138
80 schema:name Pten is essential for embryonic development and tumour suppression
81 schema:pagination 348-355
82 schema:productId N01bf4fc9e5cd45e7aee6ddcb4ea0c739
83 N43a88d8c654f47f7b56ae286191c08fc
84 N665d902ce8df44eea92ad4a85301009b
85 N72f0b2d237c34ffd9c0fe176cdcd9888
86 Nb7216b056b014f26b0e0c6961d2cb258
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033843315
88 https://doi.org/10.1038/1235
89 schema:sdDatePublished 2019-04-11T12:22
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N7b567bda66674bc2b4beed9eca840dcd
92 schema:url http://www.nature.com/ng/journal/v19/n4/full/ng0898_348.html
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N01bf4fc9e5cd45e7aee6ddcb4ea0c739 schema:name readcube_id
97 schema:value a138315ae9706e4094dcaa772babd0606ba4830b234dfb4af3958b0522ad37c6
98 rdf:type schema:PropertyValue
99 N08cca523b20545448c56576f8be0ddad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Phosphoric Monoester Hydrolases
101 rdf:type schema:DefinedTerm
102 N0a12a006ae7d485a9cf2c14546fe41dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Germ-Line Mutation
104 rdf:type schema:DefinedTerm
105 N21a23cf3314741d6b7fa1cc3991dd99f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Adenocarcinoma
107 rdf:type schema:DefinedTerm
108 N28f5ec32353f4721a445bc3dba51d311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice, Knockout
110 rdf:type schema:DefinedTerm
111 N2bfde9b8112a4f10b9eb2bfa402bd3e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cell Adhesion
113 rdf:type schema:DefinedTerm
114 N2e4f499e9cdf46caa0000542bedcca26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N35d30fd91640475ab81e79a89fa4a965 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Genes, Tumor Suppressor
119 rdf:type schema:DefinedTerm
120 N414a23089b874b33a70659fd2fe4396c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cells, Cultured
122 rdf:type schema:DefinedTerm
123 N43a88d8c654f47f7b56ae286191c08fc schema:name nlm_unique_id
124 schema:value 9216904
125 rdf:type schema:PropertyValue
126 N44c2fcd6b8dd46ce87981b646cacc65d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name RNA, Messenger
128 rdf:type schema:DefinedTerm
129 N4513c9666f224460aae09d072f94e7d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Embryonic and Fetal Development
131 rdf:type schema:DefinedTerm
132 N4b272b75cd5e4e3187222b59db449de0 rdf:first Nb6f37fe491404deab6893ac78b053213
133 rdf:rest Nbc473632b75e4218a4edeb35e9a86ec9
134 N4c2b523c3b0243ccb86ea6d5241939b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name PTEN Phosphohydrolase
136 rdf:type schema:DefinedTerm
137 N519d905bfe754c3082835e0f7bb696c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Genes, Lethal
139 rdf:type schema:DefinedTerm
140 N5c0e2fb278154189bc3488c1058099b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mice
142 rdf:type schema:DefinedTerm
143 N607389d0be3142dc9ad493b286fa3af0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 N63d5b52acf4b46199bb66f925620d425 rdf:first sg:person.0606367352.90
147 rdf:rest N4b272b75cd5e4e3187222b59db449de0
148 N665d902ce8df44eea92ad4a85301009b schema:name dimensions_id
149 schema:value pub.1033843315
150 rdf:type schema:PropertyValue
151 N7180a5d614df4d638eaa0b39c043a852 schema:volumeNumber 19
152 rdf:type schema:PublicationVolume
153 N72f0b2d237c34ffd9c0fe176cdcd9888 schema:name pubmed_id
154 schema:value 9697695
155 rdf:type schema:PropertyValue
156 N7b567bda66674bc2b4beed9eca840dcd schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 N86da03fc376c41ee8ed7e6c651687dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Testicular Neoplasms
160 rdf:type schema:DefinedTerm
161 N88857de3429b445ca65b39c2f6583adb rdf:first sg:person.01355745464.73
162 rdf:rest rdf:nil
163 N8c746fdb36694f32bf15ea08379c482a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasms, Experimental
165 rdf:type schema:DefinedTerm
166 N90defcdd00bf4afcb9efc6ada5cf70f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Teratocarcinoma
168 rdf:type schema:DefinedTerm
169 N91b80cfdeb3e4e4a878d8761383e694c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Colonic Neoplasms
171 rdf:type schema:DefinedTerm
172 N938f467f695e435d8c1babd1e2f0a68c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Hamartoma Syndrome, Multiple
174 rdf:type schema:DefinedTerm
175 Nae12a55bb3be4a80acef60af237816f1 schema:issueNumber 4
176 rdf:type schema:PublicationIssue
177 Nb6f37fe491404deab6893ac78b053213 schema:familyName Pesce
178 schema:givenName B
179 rdf:type schema:Person
180 Nb7216b056b014f26b0e0c6961d2cb258 schema:name doi
181 schema:value 10.1038/1235
182 rdf:type schema:PropertyValue
183 Nb91e613fee0d4e069a5a1a8d5bd62719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Protein Tyrosine Phosphatases
185 rdf:type schema:DefinedTerm
186 Nbc473632b75e4218a4edeb35e9a86ec9 rdf:first sg:person.01104343103.39
187 rdf:rest N88857de3429b445ca65b39c2f6583adb
188 Nbd6dd73f0d8748cab97082832586392a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Tumor Suppressor Proteins
190 rdf:type schema:DefinedTerm
191 Nc3a3d5a6c6ac458b888813a5e3d44ee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Animals
193 rdf:type schema:DefinedTerm
194 Nd29b3051a26940c5a045dca41bee602f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Thyroid Neoplasms
196 rdf:type schema:DefinedTerm
197 Nde10500567fa463aa1ef29b531e8ee38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Stem Cells
199 rdf:type schema:DefinedTerm
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biochemistry and Cell Biology
205 rdf:type schema:DefinedTerm
206 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/1235
207 rdf:type schema:MonetaryGrant
208 sg:journal.1103138 schema:issn 1061-4036
209 1546-1718
210 schema:name Nature Genetics
211 rdf:type schema:Periodical
212 sg:person.01104343103.39 schema:familyName Cordon-Cardo
213 schema:givenName C
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104343103.39
215 rdf:type schema:Person
216 sg:person.01355745464.73 schema:familyName Pandolfi
217 schema:givenName P P
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355745464.73
219 rdf:type schema:Person
220 sg:person.0606367352.90 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
221 schema:familyName Di Cristofano
222 schema:givenName A
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606367352.90
224 rdf:type schema:Person
225 sg:pub.10.1007/bf00690290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049917070
226 https://doi.org/10.1007/bf00690290
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/31008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028012299
229 https://doi.org/10.1038/31008
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ng0395-249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006649779
232 https://doi.org/10.1038/ng0395-249
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ng0497-356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048219802
235 https://doi.org/10.1038/ng0497-356
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ng0597-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006875378
238 https://doi.org/10.1038/ng0597-64
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nsb1295-1043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018709271
241 https://doi.org/10.1038/nsb1295-1043
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1080020802 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1080802476 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1082741025 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082884249 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1083134687 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1083143224 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1083167108 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1083195929 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1083202724 schema:CreativeWork
252 https://doi.org/10.1002/(sici)1098-2264(199801)21:1<61::aid-gcc8>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004328406
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/ajmg.1320440309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046091300
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/ana.410290511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042169010
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1006/excr.1994.1331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026611733
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1006/geno.1994.1336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036252265
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1006/geno.1994.1496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026080794
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0076-6879(93)25057-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047671222
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/0092-8674(87)90646-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039136966
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0092-8674(91)90011-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1002324347
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0092-8674(95)90169-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031566912
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0022-3476(76)80397-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008632040
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0092-8674(00)81079-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037997315
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0092-8674(00)81132-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051679530
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.94.23.12479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053661834
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.95.9.5246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045674792
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1086/301659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609271
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1093/hmg/6.8.1383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028976609
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/hmg/7.3.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031502567
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1101/gad.12.1.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042750690
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1101/gad.8.20.2466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043002304
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1101/gad.9.17.2105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003744681
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.275.5308.1943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014605015
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1126/science.280.5366.1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561056
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1126/science.280.5366.1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561070
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.280.5369.1614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561345
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1128/mcb.13.1.473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052782342
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1136/jmg.31.6.458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025578929
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1172/jci119613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006330923
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
309 schema:name Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, NY 10021, USA.
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...