A new Drosophila APC homologue associated with adhesive zones of epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-07

AUTHORS

X Yu, L Waltzer, M Bienz

ABSTRACT

Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin homologue, Armadillo, we identify a new Drosophila APC homologue, E-APC. E-APC also binds to Shaggy, the Drosophila GSK-3 homologue. Interference with E-APC function produces embryonic phenotypes like those of shaggy mutants. Interestingly, E-APC is concentrated in apicolateral adhesive zones of epithelial cells, along with Armadillo and E-cadherin, which are both integral components of the adherens junctions in these zones. Various mutant conditions that cause dissociation of E-APC from these zones also obliterate the segmental modulation of free Armadillo levels that is normally induced by Wingless signalling. We propose that the Armadillo-destabilizing protein complex, consisting of E-APC, Shaggy, and a third protein, Axin, is anchored in adhesive zones, and that Wingless signalling may inhibit the activity of this complex by causing dissociation of E-APC from these zones. More... »

PAGES

144-151

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/11064

DOI

http://dx.doi.org/10.1038/11064

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012175408

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10559900


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenomatous Polyposis Coli Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Armadillo Domain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, APC", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Cambridge, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "X", 
        "id": "sg:person.01357146113.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357146113.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Waltzer", 
        "givenName": "L", 
        "id": "sg:person.0742351536.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742351536.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bienz", 
        "givenName": "M", 
        "id": "sg:person.0771463105.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771463105.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.275.5307.1787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002102308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.6.672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003375997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90351-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003682027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80024-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003955744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1994.1287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004897200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.0157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006992617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0955-0674(94)90098-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008505402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(98)80039-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009640450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.113.3.657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009760953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81333-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014745301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90070-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015370041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.1.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017424386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9525(90)90010-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020662994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.1.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021323884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.1.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023011385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/26785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026674370", 
          "https://doi.org/10.1038/26785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/26785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026674370", 
          "https://doi.org/10.1038/26785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-419x(97)00008-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029277696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80531-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031155817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/383627a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033143139", 
          "https://doi.org/10.1038/383627a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.132.6.1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035453621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81725-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037243090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81096-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037402222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(99)00072-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038351203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.950190807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038636020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(88)90010-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040260135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81924-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041383393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81461-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042372742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5382.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042662127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.5.1283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042782159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.1.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044831319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80352-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046410451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.7.3034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047980528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382225a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048857666", 
          "https://doi.org/10.1038/382225a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.20.2527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049612654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.6.659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050929079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.136.2.411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051029699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80210-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052620583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.7.3046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052633521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5264.1023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5363.596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062560869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5408.1739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062564489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07477.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078320958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082439528", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05896.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082650793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082674430", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082709342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082886296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082886306", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083103529", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083350365", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-07", 
    "datePublishedReg": "1999-07-01", 
    "description": "Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin homologue, Armadillo, we identify a new Drosophila APC homologue, E-APC. E-APC also binds to Shaggy, the Drosophila GSK-3 homologue. Interference with E-APC function produces embryonic phenotypes like those of shaggy mutants. Interestingly, E-APC is concentrated in apicolateral adhesive zones of epithelial cells, along with Armadillo and E-cadherin, which are both integral components of the adherens junctions in these zones. Various mutant conditions that cause dissociation of E-APC from these zones also obliterate the segmental modulation of free Armadillo levels that is normally induced by Wingless signalling. We propose that the Armadillo-destabilizing protein complex, consisting of E-APC, Shaggy, and a third protein, Axin, is anchored in adhesive zones, and that Wingless signalling may inhibit the activity of this complex by causing dissociation of E-APC from these zones.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/11064", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "A new Drosophila APC homologue associated with adhesive zones of epithelial cells", 
    "pagination": "144-151", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3a01ef6b3f448ed8c166149aa6de6fa9b7cb89849cf3a458630c7123949c4e0d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10559900"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/11064"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012175408"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/11064", 
      "https://app.dimensions.ai/details/publication/pub.1012175408"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncb/journal/v1/n3/full/ncb0799_144.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/11064'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/11064'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/11064'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/11064'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      104 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/11064 schema:about N12f44da1e0024f92bd327d4e5ef9b57e
2 N13720071cb7846c99a45a685b3da1fc8
3 N14d1cd14a9904a81b4be54e12e882800
4 N1966e772f8134ae9addb8efadbf492fa
5 N227f0ee5544844ad860880562c2f314d
6 N253d884350f6492ab237d01cd8c15c91
7 N3b822c809ba34a4fae1a13ceb2aa5f26
8 N3bf89b1087544d11883f72160672ce8a
9 N50774afd1f04420b9a741c7fbbc78c8a
10 N57e6d40fa8ca439ca82e04556e7e83e8
11 N5b250965efa84404a4cd93a5403c096a
12 N61671caf9adf4d8b9b473a62e3e989be
13 N6bc2554b16cb49208a10e9739f1f7822
14 N87f4e080bd2845f586329d3af39727b5
15 N8ad92296806b4381a8fd969df56bee17
16 Na76ed3da897c4b73a36c0f206d922aab
17 Nba831c07ecb64f1bb81c30b7b2ca34a2
18 Nbbfc5f3afe8144368c1e9c26316bf05e
19 Nbd4e420e6f974d13aa7651cb8a011622
20 Nc635378adb764516ac3317a8bf233759
21 Ne9b0ce1e916546158b85334fcf61c3a1
22 Nf87b3d63bc784e8c8fcc46ae15d44568
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author N657ada71dad145da82990722383ea6e7
26 schema:citation sg:pub.10.1038/18884
27 sg:pub.10.1038/26785
28 sg:pub.10.1038/382225a0
29 sg:pub.10.1038/383627a0
30 https://app.dimensions.ai/details/publication/pub.1082439528
31 https://app.dimensions.ai/details/publication/pub.1082674430
32 https://app.dimensions.ai/details/publication/pub.1082709342
33 https://app.dimensions.ai/details/publication/pub.1082886296
34 https://app.dimensions.ai/details/publication/pub.1082886306
35 https://app.dimensions.ai/details/publication/pub.1083103529
36 https://app.dimensions.ai/details/publication/pub.1083350365
37 https://doi.org/10.1002/bies.950190807
38 https://doi.org/10.1002/j.1460-2075.1990.tb07477.x
39 https://doi.org/10.1002/j.1460-2075.1993.tb05896.x
40 https://doi.org/10.1006/dbio.1994.1287
41 https://doi.org/10.1006/dbio.1996.0157
42 https://doi.org/10.1016/0022-2836(88)90010-1
43 https://doi.org/10.1016/0092-8674(94)90070-1
44 https://doi.org/10.1016/0092-8674(94)90351-4
45 https://doi.org/10.1016/0168-9525(90)90010-4
46 https://doi.org/10.1016/0955-0674(94)90098-1
47 https://doi.org/10.1016/s0092-8674(00)80210-x
48 https://doi.org/10.1016/s0092-8674(00)80352-9
49 https://doi.org/10.1016/s0092-8674(00)80531-0
50 https://doi.org/10.1016/s0092-8674(00)81096-x
51 https://doi.org/10.1016/s0092-8674(00)81333-1
52 https://doi.org/10.1016/s0092-8674(00)81461-0
53 https://doi.org/10.1016/s0092-8674(00)81725-0
54 https://doi.org/10.1016/s0092-8674(00)81924-8
55 https://doi.org/10.1016/s0304-419x(97)00008-5
56 https://doi.org/10.1016/s0925-4773(99)00072-6
57 https://doi.org/10.1016/s0955-0674(98)80039-2
58 https://doi.org/10.1016/s0960-9822(99)80024-4
59 https://doi.org/10.1073/pnas.92.7.3046
60 https://doi.org/10.1073/pnas.94.1.242
61 https://doi.org/10.1073/pnas.94.7.3034
62 https://doi.org/10.1083/jcb.113.3.657
63 https://doi.org/10.1083/jcb.132.6.1105
64 https://doi.org/10.1083/jcb.134.1.133
65 https://doi.org/10.1083/jcb.134.1.149
66 https://doi.org/10.1083/jcb.134.1.165
67 https://doi.org/10.1083/jcb.134.5.1283
68 https://doi.org/10.1083/jcb.136.2.411
69 https://doi.org/10.1101/gad.10.20.2527
70 https://doi.org/10.1101/gad.10.6.659
71 https://doi.org/10.1101/gad.10.6.672
72 https://doi.org/10.1126/science.272.5264.1023
73 https://doi.org/10.1126/science.275.5307.1784
74 https://doi.org/10.1126/science.275.5307.1787
75 https://doi.org/10.1126/science.275.5307.1790
76 https://doi.org/10.1126/science.280.5363.596
77 https://doi.org/10.1126/science.281.5382.1509
78 https://doi.org/10.1126/science.283.5408.1739
79 schema:datePublished 1999-07
80 schema:datePublishedReg 1999-07-01
81 schema:description Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin homologue, Armadillo, we identify a new Drosophila APC homologue, E-APC. E-APC also binds to Shaggy, the Drosophila GSK-3 homologue. Interference with E-APC function produces embryonic phenotypes like those of shaggy mutants. Interestingly, E-APC is concentrated in apicolateral adhesive zones of epithelial cells, along with Armadillo and E-cadherin, which are both integral components of the adherens junctions in these zones. Various mutant conditions that cause dissociation of E-APC from these zones also obliterate the segmental modulation of free Armadillo levels that is normally induced by Wingless signalling. We propose that the Armadillo-destabilizing protein complex, consisting of E-APC, Shaggy, and a third protein, Axin, is anchored in adhesive zones, and that Wingless signalling may inhibit the activity of this complex by causing dissociation of E-APC from these zones.
82 schema:genre research_article
83 schema:inLanguage en
84 schema:isAccessibleForFree false
85 schema:isPartOf N22953a17be724af4b9a258ade1b87578
86 Nf85603939af84e3d85b6b9957a72d3d2
87 sg:journal.1021344
88 schema:name A new Drosophila APC homologue associated with adhesive zones of epithelial cells
89 schema:pagination 144-151
90 schema:productId N334e2aff939348f8b3ac34c891b3a3bb
91 N41db801e1d3642ee8919638355ce7d5d
92 N8503dcb415b844a8a9387c68cc6d9c49
93 Nd87b0c1dfd884ec6af8aec7baac0184c
94 Ndf86cf029db343889121e2cd5def0282
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012175408
96 https://doi.org/10.1038/11064
97 schema:sdDatePublished 2019-04-11T12:20
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N53450598e07f4ce69bd0391f1e5c95f7
100 schema:url http://www.nature.com/ncb/journal/v1/n3/full/ncb0799_144.html
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N12f44da1e0024f92bd327d4e5ef9b57e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Sequence Homology, Amino Acid
106 rdf:type schema:DefinedTerm
107 N13720071cb7846c99a45a685b3da1fc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Binding Sites
109 rdf:type schema:DefinedTerm
110 N14d1cd14a9904a81b4be54e12e882800 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Drosophila Proteins
112 rdf:type schema:DefinedTerm
113 N1966e772f8134ae9addb8efadbf492fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name RNA, Double-Stranded
115 rdf:type schema:DefinedTerm
116 N227f0ee5544844ad860880562c2f314d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Drosophila melanogaster
118 rdf:type schema:DefinedTerm
119 N22953a17be724af4b9a258ade1b87578 schema:volumeNumber 1
120 rdf:type schema:PublicationVolume
121 N253d884350f6492ab237d01cd8c15c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cytoskeletal Proteins
123 rdf:type schema:DefinedTerm
124 N334e2aff939348f8b3ac34c891b3a3bb schema:name readcube_id
125 schema:value 3a01ef6b3f448ed8c166149aa6de6fa9b7cb89849cf3a458630c7123949c4e0d
126 rdf:type schema:PropertyValue
127 N3b822c809ba34a4fae1a13ceb2aa5f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Microscopy, Confocal
129 rdf:type schema:DefinedTerm
130 N3bf89b1087544d11883f72160672ce8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N41db801e1d3642ee8919638355ce7d5d schema:name nlm_unique_id
134 schema:value 100890575
135 rdf:type schema:PropertyValue
136 N50774afd1f04420b9a741c7fbbc78c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Adenomatous Polyposis Coli Protein
138 rdf:type schema:DefinedTerm
139 N53450598e07f4ce69bd0391f1e5c95f7 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N57e6d40fa8ca439ca82e04556e7e83e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Epithelial Cells
143 rdf:type schema:DefinedTerm
144 N5b250965efa84404a4cd93a5403c096a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Amino Acid Sequence
146 rdf:type schema:DefinedTerm
147 N61671caf9adf4d8b9b473a62e3e989be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Phenotype
149 rdf:type schema:DefinedTerm
150 N657ada71dad145da82990722383ea6e7 rdf:first sg:person.01357146113.09
151 rdf:rest Nf02a7bed4b28411497ee3d626ca0eede
152 N6bc2554b16cb49208a10e9739f1f7822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Trans-Activators
154 rdf:type schema:DefinedTerm
155 N8503dcb415b844a8a9387c68cc6d9c49 schema:name doi
156 schema:value 10.1038/11064
157 rdf:type schema:PropertyValue
158 N87f4e080bd2845f586329d3af39727b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Molecular Sequence Data
160 rdf:type schema:DefinedTerm
161 N8ad92296806b4381a8fd969df56bee17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 N9a6eb332ddbd476f8c38b881b2f54d70 rdf:first sg:person.0771463105.43
165 rdf:rest rdf:nil
166 Na76ed3da897c4b73a36c0f206d922aab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Cell Adhesion
168 rdf:type schema:DefinedTerm
169 Nba831c07ecb64f1bb81c30b7b2ca34a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Insect Proteins
171 rdf:type schema:DefinedTerm
172 Nbbfc5f3afe8144368c1e9c26316bf05e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Sequence Alignment
174 rdf:type schema:DefinedTerm
175 Nbd4e420e6f974d13aa7651cb8a011622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Genes, APC
177 rdf:type schema:DefinedTerm
178 Nc635378adb764516ac3317a8bf233759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transcription Factors
180 rdf:type schema:DefinedTerm
181 Nd87b0c1dfd884ec6af8aec7baac0184c schema:name dimensions_id
182 schema:value pub.1012175408
183 rdf:type schema:PropertyValue
184 Ndf86cf029db343889121e2cd5def0282 schema:name pubmed_id
185 schema:value 10559900
186 rdf:type schema:PropertyValue
187 Ne9b0ce1e916546158b85334fcf61c3a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cell Membrane
189 rdf:type schema:DefinedTerm
190 Nf02a7bed4b28411497ee3d626ca0eede rdf:first sg:person.0742351536.11
191 rdf:rest N9a6eb332ddbd476f8c38b881b2f54d70
192 Nf85603939af84e3d85b6b9957a72d3d2 schema:issueNumber 3
193 rdf:type schema:PublicationIssue
194 Nf87b3d63bc784e8c8fcc46ae15d44568 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Armadillo Domain Proteins
196 rdf:type schema:DefinedTerm
197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
198 schema:name Biological Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biochemistry and Cell Biology
202 rdf:type schema:DefinedTerm
203 sg:journal.1021344 schema:issn 1465-7392
204 1476-4679
205 schema:name Nature Cell Biology
206 rdf:type schema:Periodical
207 sg:person.01357146113.09 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
208 schema:familyName Yu
209 schema:givenName X
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357146113.09
211 rdf:type schema:Person
212 sg:person.0742351536.11 schema:familyName Waltzer
213 schema:givenName L
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742351536.11
215 rdf:type schema:Person
216 sg:person.0771463105.43 schema:familyName Bienz
217 schema:givenName M
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771463105.43
219 rdf:type schema:Person
220 sg:pub.10.1038/18884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595361
221 https://doi.org/10.1038/18884
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/26785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026674370
224 https://doi.org/10.1038/26785
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/382225a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048857666
227 https://doi.org/10.1038/382225a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/383627a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033143139
230 https://doi.org/10.1038/383627a0
231 rdf:type schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1082439528 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082674430 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082709342 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1082886296 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1082886306 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1083103529 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1083350365 schema:CreativeWork
239 https://doi.org/10.1002/bies.950190807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038636020
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/j.1460-2075.1990.tb07477.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078320958
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/j.1460-2075.1993.tb05896.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082650793
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1006/dbio.1994.1287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004897200
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1006/dbio.1996.0157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006992617
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0022-2836(88)90010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040260135
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0092-8674(94)90070-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015370041
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0092-8674(94)90351-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003682027
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0168-9525(90)90010-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020662994
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0955-0674(94)90098-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008505402
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0092-8674(00)80210-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052620583
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0092-8674(00)80352-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046410451
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0092-8674(00)80531-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031155817
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0092-8674(00)81096-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037402222
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0092-8674(00)81333-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745301
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0092-8674(00)81461-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042372742
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0092-8674(00)81725-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037243090
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0092-8674(00)81924-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041383393
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0304-419x(97)00008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029277696
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0925-4773(99)00072-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038351203
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0955-0674(98)80039-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009640450
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0960-9822(99)80024-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003955744
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.92.7.3046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052633521
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.94.1.242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017424386
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.94.7.3034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047980528
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1083/jcb.113.3.657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009760953
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1083/jcb.132.6.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035453621
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1083/jcb.134.1.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021323884
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1083/jcb.134.1.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044831319
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1083/jcb.134.1.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023011385
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1083/jcb.134.5.1283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782159
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1083/jcb.136.2.411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051029699
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1101/gad.10.20.2527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049612654
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1101/gad.10.6.659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050929079
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1101/gad.10.6.672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003375997
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1126/science.272.5264.1023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553011
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1126/science.275.5307.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556119
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.275.5307.1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102308
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.275.5307.1790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556120
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1126/science.280.5363.596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062560869
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1126/science.281.5382.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662127
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1126/science.283.5408.1739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564489
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
324 schema:name MRC Laboratory of Molecular Biology, Cambridge, UK.
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...