Distance from the Coronary Ostium to the Culprit Lesion in Acute ST-Elevation Myocardial Infarction and its Implications Regarding the Potential ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

C. Michael Gibson, Ajay J. Kirtane, Sabina A. Murphy, Juhana Karha, Christopher P. Cannon, Robert P. Giugliano, Mathew T. Roe, Robert A. Harrington, E. Magnus Ohman, Elliott M. Antman

ABSTRACT

BACKGROUND: Shorter distances from the coronary ostia to culprit lesions have been associated with a higher incidence of adverse outcomes in ST elevation acute myocardial infarction (STEMI). As drug-eluting stents are associated with low rates of restenosis and formation of a stable intima, we sought to develop a mathematical model to estimate how far down the coronary artery a drug-eluting stent would have to be placed to theoretically mitigate the risk of proximal plaque rupture. OBJECTIVES AND METHODS: Distances from the ostia to the end of the culprit lesions were planimetered in 1,914 patients from the TIMI 14, INTEGRITI, FASTER and ENTIRE/TIMI 23 trials. RESULTS: The first 60 mm of the coronary artery contained 75% of STEMI culprit lesions. The median distance from the vessel ostium to the end of the culprit lesion was 43 mm (mean 50 +/- 34) and the relative distance from the vessel ostium to the end of the lesion was 29% (mean 33 +/- 17%) of the total culprit artery length. Diabetes was the only baseline clinical characteristic associated with a longer absolute distance to the end of the culprit lesion (46 mm vs. 43 mm, p = 0.03) as well as relative to total artery length (31% vs. 29%, p = 0.04). Median distances from the artery ostium to the end of the culprit lesion were shortest among the left anterior descending culprits (40 mm), followed by circumflex lesions (43 mm) and then right coronary artery lesions (47 mm, 3-way p < 0.0001). CONCLUSION: The majority of culprit lesions in STEMI are contained within the proximal 30% of the major epicardial coronary arteries, but the distance varies depending upon which epicardial artery is involved. Cumulative distribution functions are presented to allow estimation of the percent of culprit lesions lying proximal to any given distance from the ostium to model the feasibility of prophylactic drug-eluting stenting to minimize the risk of subsequent proximal plaque rupture. More... »

PAGES

189-196

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:thro.0000011374.60110.bc

DOI

http://dx.doi.org/10.1023/b:thro.0000011374.60110.bc

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011454259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14739628


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Equipment Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rupture, Post-Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Cardiovascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stents", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibson", 
        "givenName": "C. Michael", 
        "id": "sg:person.0750215673.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750215673.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Division of Cardiology, Beth Israel Deaconess Medical Center, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirtane", 
        "givenName": "Ajay J.", 
        "id": "sg:person.01025226133.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025226133.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Sabina A.", 
        "id": "sg:person.0714034144.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714034144.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karha", 
        "givenName": "Juhana", 
        "id": "sg:person.01061350521.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061350521.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannon", 
        "givenName": "Christopher P.", 
        "id": "sg:person.01172544713.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172544713.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giugliano", 
        "givenName": "Robert P.", 
        "id": "sg:person.0702207604.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702207604.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke Clinical Research Institute, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roe", 
        "givenName": "Mathew T.", 
        "id": "sg:person.01012073574.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012073574.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke Clinical Research Institute, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrington", 
        "givenName": "Robert A.", 
        "id": "sg:person.01212601375.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212601375.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "University of North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohman", 
        "givenName": "E. Magnus", 
        "id": "sg:person.01143421660.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143421660.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thrombolysis in Myocardial Infarction Study Group", 
          "id": "https://www.grid.ac/institutes/grid.492942.0", 
          "name": [
            "TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antman", 
        "givenName": "Elliott M.", 
        "id": "sg:person.015737165557.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015737165557.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0002-9149(92)90495-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004017822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000013402.34759.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005846812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.103.25.3142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006711362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000025585.63486.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008072480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000034392.34211.fc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011420451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ccd.1810360402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015448153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.17.2063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017900152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.78.5.1157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018362682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(96)00244-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022094003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)82500-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022467206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000012528.89469.8e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026613482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(97)00747-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027522063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.78.5.1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028269170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc3601.093987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031166399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000019743.11941.3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033684242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(93)90714-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034204388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(88)90356-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035245482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1540-8183.1996.tb00654.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00123-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037948616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00123-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037948616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(99)00533-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038445191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000051720.59095.6d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038892626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(98)01070-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040424014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(98)01072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041394668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000025629.85631.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043362737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.21.2720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045038090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(01)01207-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052740991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/euhj.2000.2243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057074554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.96.2.468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063338246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-137-10-200211190-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073705545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083292756", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-06", 
    "datePublishedReg": "2003-06-01", 
    "description": "BACKGROUND: Shorter distances from the coronary ostia to culprit lesions have been associated with a higher incidence of adverse outcomes in ST elevation acute myocardial infarction (STEMI). As drug-eluting stents are associated with low rates of restenosis and formation of a stable intima, we sought to develop a mathematical model to estimate how far down the coronary artery a drug-eluting stent would have to be placed to theoretically mitigate the risk of proximal plaque rupture.\nOBJECTIVES AND METHODS: Distances from the ostia to the end of the culprit lesions were planimetered in 1,914 patients from the TIMI 14, INTEGRITI, FASTER and ENTIRE/TIMI 23 trials.\nRESULTS: The first 60 mm of the coronary artery contained 75% of STEMI culprit lesions. The median distance from the vessel ostium to the end of the culprit lesion was 43 mm (mean 50 +/- 34) and the relative distance from the vessel ostium to the end of the lesion was 29% (mean 33 +/- 17%) of the total culprit artery length. Diabetes was the only baseline clinical characteristic associated with a longer absolute distance to the end of the culprit lesion (46 mm vs. 43 mm, p = 0.03) as well as relative to total artery length (31% vs. 29%, p = 0.04). Median distances from the artery ostium to the end of the culprit lesion were shortest among the left anterior descending culprits (40 mm), followed by circumflex lesions (43 mm) and then right coronary artery lesions (47 mm, 3-way p < 0.0001).\nCONCLUSION: The majority of culprit lesions in STEMI are contained within the proximal 30% of the major epicardial coronary arteries, but the distance varies depending upon which epicardial artery is involved. Cumulative distribution functions are presented to allow estimation of the percent of culprit lesions lying proximal to any given distance from the ostium to model the feasibility of prophylactic drug-eluting stenting to minimize the risk of subsequent proximal plaque rupture.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/b:thro.0000011374.60110.bc", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113719", 
        "issn": [
          "0929-5305", 
          "1573-742X"
        ], 
        "name": "Journal of Thrombosis and Thrombolysis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Distance from the Coronary Ostium to the Culprit Lesion in Acute ST-Elevation Myocardial Infarction and its Implications Regarding the Potential Prevention of Proximal Plaque Rupture", 
    "pagination": "189-196", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "36928f7428fd0c6407479bf2ee165220fcf5a3d527370913df2d0a51e8d6d03b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14739628"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502018"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/b:thro.0000011374.60110.bc"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011454259"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/b:thro.0000011374.60110.bc", 
      "https://app.dimensions.ai/details/publication/pub.1011454259"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FB%3ATHRO.0000011374.60110.bc"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/b:thro.0000011374.60110.bc'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:thro.0000011374.60110.bc'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:thro.0000011374.60110.bc'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/b:thro.0000011374.60110.bc'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      72 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/b:thro.0000011374.60110.bc schema:about N2019a874f5e749adbbb6e109445c1761
2 N4ad7152419554ff59e10bf8012747ca5
3 N56e079032c0d47eb94cdfc366607e7a4
4 N5d86a80056fc4f6ab0631f3e36f22370
5 N63f4fc9d27d1464bbf670ecf8c960006
6 N7d27a00329f441fda88ce3a0390dc4ee
7 N8650809092c644398e8176b980081091
8 N98995d0eb4824b4aaac10e898b4fba2b
9 Na21ca22027d0478392dd87aef7d74dbd
10 Ncb43c43e4d5940cf947edd1850b0ee7e
11 Nd78cf03bb40a4725884f16b04f7bb256
12 Ne7b1f5e11bb643979324a71251ad6d7e
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Nbdd0d47dea214d528310097720fec6e7
16 schema:citation https://app.dimensions.ai/details/publication/pub.1083292756
17 https://doi.org/10.1002/ccd.1810360402
18 https://doi.org/10.1016/0002-9149(92)90495-k
19 https://doi.org/10.1016/0735-1097(88)90356-7
20 https://doi.org/10.1016/0735-1097(93)90714-c
21 https://doi.org/10.1016/s0002-9149(97)00747-9
22 https://doi.org/10.1016/s0002-9149(98)01070-4
23 https://doi.org/10.1016/s0002-9149(98)01072-8
24 https://doi.org/10.1016/s0735-1097(01)01207-4
25 https://doi.org/10.1016/s0735-1097(03)00123-2
26 https://doi.org/10.1016/s0735-1097(03)82500-7
27 https://doi.org/10.1016/s0735-1097(96)00244-6
28 https://doi.org/10.1016/s0735-1097(99)00533-1
29 https://doi.org/10.1053/euhj.2000.2243
30 https://doi.org/10.1056/nejmoa012843
31 https://doi.org/10.1111/j.1540-8183.1996.tb00654.x
32 https://doi.org/10.1161/01.cir.0000012528.89469.8e
33 https://doi.org/10.1161/01.cir.0000013402.34759.46
34 https://doi.org/10.1161/01.cir.0000019743.11941.3b
35 https://doi.org/10.1161/01.cir.0000025585.63486.59
36 https://doi.org/10.1161/01.cir.0000025629.85631.1e
37 https://doi.org/10.1161/01.cir.0000034392.34211.fc
38 https://doi.org/10.1161/01.cir.0000051720.59095.6d
39 https://doi.org/10.1161/01.cir.102.17.2063
40 https://doi.org/10.1161/01.cir.103.25.3142
41 https://doi.org/10.1161/01.cir.78.5.1157
42 https://doi.org/10.1161/01.cir.78.5.1167
43 https://doi.org/10.1161/01.cir.96.2.468
44 https://doi.org/10.1161/01.cir.99.21.2720
45 https://doi.org/10.1161/hc3601.093987
46 https://doi.org/10.7326/0003-4819-137-10-200211190-00012
47 schema:datePublished 2003-06
48 schema:datePublishedReg 2003-06-01
49 schema:description BACKGROUND: Shorter distances from the coronary ostia to culprit lesions have been associated with a higher incidence of adverse outcomes in ST elevation acute myocardial infarction (STEMI). As drug-eluting stents are associated with low rates of restenosis and formation of a stable intima, we sought to develop a mathematical model to estimate how far down the coronary artery a drug-eluting stent would have to be placed to theoretically mitigate the risk of proximal plaque rupture. OBJECTIVES AND METHODS: Distances from the ostia to the end of the culprit lesions were planimetered in 1,914 patients from the TIMI 14, INTEGRITI, FASTER and ENTIRE/TIMI 23 trials. RESULTS: The first 60 mm of the coronary artery contained 75% of STEMI culprit lesions. The median distance from the vessel ostium to the end of the culprit lesion was 43 mm (mean 50 +/- 34) and the relative distance from the vessel ostium to the end of the lesion was 29% (mean 33 +/- 17%) of the total culprit artery length. Diabetes was the only baseline clinical characteristic associated with a longer absolute distance to the end of the culprit lesion (46 mm vs. 43 mm, p = 0.03) as well as relative to total artery length (31% vs. 29%, p = 0.04). Median distances from the artery ostium to the end of the culprit lesion were shortest among the left anterior descending culprits (40 mm), followed by circumflex lesions (43 mm) and then right coronary artery lesions (47 mm, 3-way p < 0.0001). CONCLUSION: The majority of culprit lesions in STEMI are contained within the proximal 30% of the major epicardial coronary arteries, but the distance varies depending upon which epicardial artery is involved. Cumulative distribution functions are presented to allow estimation of the percent of culprit lesions lying proximal to any given distance from the ostium to model the feasibility of prophylactic drug-eluting stenting to minimize the risk of subsequent proximal plaque rupture.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf Nab924adcdfff4035b7c0f881a22640a8
54 Nb22837c4357e463b811a6caa05de0f18
55 sg:journal.1113719
56 schema:name Distance from the Coronary Ostium to the Culprit Lesion in Acute ST-Elevation Myocardial Infarction and its Implications Regarding the Potential Prevention of Proximal Plaque Rupture
57 schema:pagination 189-196
58 schema:productId N870fcffd73044e099fe3b38abdcbed63
59 Na0b5739cf2b047769cf489cfd9c62c81
60 Na73ce35e0c394f46b3ff5d07fb0627e7
61 Nd99e6d92a3964d7d8daa47f4d9bfddcf
62 Nf29ab94c0edf4a94ba0c6116fd9b0be9
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011454259
64 https://doi.org/10.1023/b:thro.0000011374.60110.bc
65 schema:sdDatePublished 2019-04-10T23:22
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N559faac0152f4731b1b241fa4aa770d8
68 schema:url http://link.springer.com/10.1023%2FB%3ATHRO.0000011374.60110.bc
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0eb04f9318d042caba110aac9edc5724 rdf:first sg:person.0702207604.00
73 rdf:rest Ne2e66152a2404a14b53761e6868bbd15
74 N2019a874f5e749adbbb6e109445c1761 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Myocardial Infarction
76 rdf:type schema:DefinedTerm
77 N4ad7152419554ff59e10bf8012747ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Drug Delivery Systems
79 rdf:type schema:DefinedTerm
80 N559faac0152f4731b1b241fa4aa770d8 schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N56e079032c0d47eb94cdfc366607e7a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Aged
84 rdf:type schema:DefinedTerm
85 N5739b3071cf94fc0a571984b73c8f525 rdf:first sg:person.01025226133.03
86 rdf:rest N5ac0041211c64919bb2be08034eb1e8f
87 N5ac0041211c64919bb2be08034eb1e8f rdf:first sg:person.0714034144.03
88 rdf:rest Necd14f26748340e2bbe4352bca0593e6
89 N5d86a80056fc4f6ab0631f3e36f22370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Humans
91 rdf:type schema:DefinedTerm
92 N62e2690dd3e7440d824953e0745fef2a rdf:first sg:person.015737165557.39
93 rdf:rest rdf:nil
94 N63f4fc9d27d1464bbf670ecf8c960006 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Middle Aged
96 rdf:type schema:DefinedTerm
97 N6b4585a6c7784feda0ff60db352f9270 rdf:first sg:person.01172544713.06
98 rdf:rest N0eb04f9318d042caba110aac9edc5724
99 N7d27a00329f441fda88ce3a0390dc4ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N7fc66459d0344f9dbc48c1f355616659 rdf:first sg:person.01143421660.90
103 rdf:rest N62e2690dd3e7440d824953e0745fef2a
104 N8429ad22bfff409ea14b764780dc680f rdf:first sg:person.01212601375.97
105 rdf:rest N7fc66459d0344f9dbc48c1f355616659
106 N8650809092c644398e8176b980081091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Female
108 rdf:type schema:DefinedTerm
109 N870fcffd73044e099fe3b38abdcbed63 schema:name doi
110 schema:value 10.1023/b:thro.0000011374.60110.bc
111 rdf:type schema:PropertyValue
112 N98995d0eb4824b4aaac10e898b4fba2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Stents
114 rdf:type schema:DefinedTerm
115 Na0b5739cf2b047769cf489cfd9c62c81 schema:name readcube_id
116 schema:value 36928f7428fd0c6407479bf2ee165220fcf5a3d527370913df2d0a51e8d6d03b
117 rdf:type schema:PropertyValue
118 Na21ca22027d0478392dd87aef7d74dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Equipment Design
120 rdf:type schema:DefinedTerm
121 Na73ce35e0c394f46b3ff5d07fb0627e7 schema:name pubmed_id
122 schema:value 14739628
123 rdf:type schema:PropertyValue
124 Nab924adcdfff4035b7c0f881a22640a8 schema:volumeNumber 15
125 rdf:type schema:PublicationVolume
126 Nb22837c4357e463b811a6caa05de0f18 schema:issueNumber 3
127 rdf:type schema:PublicationIssue
128 Nbdd0d47dea214d528310097720fec6e7 rdf:first sg:person.0750215673.07
129 rdf:rest N5739b3071cf94fc0a571984b73c8f525
130 Ncb43c43e4d5940cf947edd1850b0ee7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Models, Cardiovascular
132 rdf:type schema:DefinedTerm
133 Nd78cf03bb40a4725884f16b04f7bb256 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Electrocardiography
135 rdf:type schema:DefinedTerm
136 Nd99e6d92a3964d7d8daa47f4d9bfddcf schema:name nlm_unique_id
137 schema:value 9502018
138 rdf:type schema:PropertyValue
139 Ne2e66152a2404a14b53761e6868bbd15 rdf:first sg:person.01012073574.16
140 rdf:rest N8429ad22bfff409ea14b764780dc680f
141 Ne7b1f5e11bb643979324a71251ad6d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Heart Rupture, Post-Infarction
143 rdf:type schema:DefinedTerm
144 Necd14f26748340e2bbe4352bca0593e6 rdf:first sg:person.01061350521.48
145 rdf:rest N6b4585a6c7784feda0ff60db352f9270
146 Nf29ab94c0edf4a94ba0c6116fd9b0be9 schema:name dimensions_id
147 schema:value pub.1011454259
148 rdf:type schema:PropertyValue
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
153 schema:name Cardiorespiratory Medicine and Haematology
154 rdf:type schema:DefinedTerm
155 sg:journal.1113719 schema:issn 0929-5305
156 1573-742X
157 schema:name Journal of Thrombosis and Thrombolysis
158 rdf:type schema:Periodical
159 sg:person.01012073574.16 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
160 schema:familyName Roe
161 schema:givenName Mathew T.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012073574.16
163 rdf:type schema:Person
164 sg:person.01025226133.03 schema:affiliation https://www.grid.ac/institutes/grid.239395.7
165 schema:familyName Kirtane
166 schema:givenName Ajay J.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025226133.03
168 rdf:type schema:Person
169 sg:person.01061350521.48 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
170 schema:familyName Karha
171 schema:givenName Juhana
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061350521.48
173 rdf:type schema:Person
174 sg:person.01143421660.90 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
175 schema:familyName Ohman
176 schema:givenName E. Magnus
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143421660.90
178 rdf:type schema:Person
179 sg:person.01172544713.06 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
180 schema:familyName Cannon
181 schema:givenName Christopher P.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172544713.06
183 rdf:type schema:Person
184 sg:person.01212601375.97 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
185 schema:familyName Harrington
186 schema:givenName Robert A.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212601375.97
188 rdf:type schema:Person
189 sg:person.015737165557.39 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
190 schema:familyName Antman
191 schema:givenName Elliott M.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015737165557.39
193 rdf:type schema:Person
194 sg:person.0702207604.00 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
195 schema:familyName Giugliano
196 schema:givenName Robert P.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702207604.00
198 rdf:type schema:Person
199 sg:person.0714034144.03 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
200 schema:familyName Murphy
201 schema:givenName Sabina A.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714034144.03
203 rdf:type schema:Person
204 sg:person.0750215673.07 schema:affiliation https://www.grid.ac/institutes/grid.492942.0
205 schema:familyName Gibson
206 schema:givenName C. Michael
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750215673.07
208 rdf:type schema:Person
209 https://app.dimensions.ai/details/publication/pub.1083292756 schema:CreativeWork
210 https://doi.org/10.1002/ccd.1810360402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015448153
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0002-9149(92)90495-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1004017822
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0735-1097(88)90356-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035245482
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/0735-1097(93)90714-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1034204388
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0002-9149(97)00747-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027522063
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0002-9149(98)01070-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040424014
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0002-9149(98)01072-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041394668
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0735-1097(01)01207-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052740991
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0735-1097(03)00123-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037948616
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0735-1097(03)82500-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022467206
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0735-1097(96)00244-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022094003
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0735-1097(99)00533-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038445191
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1053/euhj.2000.2243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057074554
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1056/nejmoa012843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026613482
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1540-8183.1996.tb00654.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035527437
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1161/01.cir.0000012528.89469.8e schema:sameAs https://app.dimensions.ai/details/publication/pub.1025974196
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1161/01.cir.0000013402.34759.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005846812
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1161/01.cir.0000019743.11941.3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1033684242
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1161/01.cir.0000025585.63486.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008072480
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1161/01.cir.0000025629.85631.1e schema:sameAs https://app.dimensions.ai/details/publication/pub.1043362737
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1161/01.cir.0000034392.34211.fc schema:sameAs https://app.dimensions.ai/details/publication/pub.1011420451
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/01.cir.0000051720.59095.6d schema:sameAs https://app.dimensions.ai/details/publication/pub.1038892626
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/01.cir.102.17.2063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017900152
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/01.cir.103.25.3142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006711362
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/01.cir.78.5.1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018362682
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1161/01.cir.78.5.1167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028269170
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1161/01.cir.96.2.468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338246
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1161/01.cir.99.21.2720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045038090
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1161/hc3601.093987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166399
267 rdf:type schema:CreativeWork
268 https://doi.org/10.7326/0003-4819-137-10-200211190-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073705545
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center
271 schema:name Division of Cardiology, Beth Israel Deaconess Medical Center, USA
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
274 schema:name Duke Clinical Research Institute, USA
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
277 schema:name University of North Carolina, USA
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.492942.0 schema:alternateName Thrombolysis in Myocardial Infarction Study Group
280 schema:name TIMI Study Group, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, USA
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...