Genetic History of Aleuts of the Commander Islands as Revealed by the Analysis of the HLA Class II Gene Variability View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12

AUTHORS

N. V. Volodko, O. A. Derbeneva, T. S. Uinuk-ool, R. I. Sukernik

ABSTRACT

Variability of the HLA class II genes (alleles of the DRB1, DQA1, and DQB1 loci) was investigated in a sample of Aleuts of the Commanders (n = 31), whose ancestors inhabited the Commander Islands for many thousand years. Among 19 haplotypes revealed in the Aleuts of the Commanders, at most eight were inherited from the native inhabitants of the Commander Islands. Five of these haplotypes (DRB1*0401-DQA1*0301-DQB1*0301, DRB1*1401-DQA1*0101-DQB1*0503, DRB1*0802-DQA1*0401-DQB1*0402, DRB1*1101-DQA1*0501-DQB1*0301, and DRB1*1201-DQA1*0501-DQB1*0301) were typical of Beringian Mongoloids, i.e., Coastal Chukchi and Koryaks, as well as Siberian and Alaskan Eskimos. Genetic contribution of the immigrants to the genetic pool of the proper Aleuts constituted about 52%. Phylogenetic analysis based on Transberingian distribution of the DRB1 allele frequencies favored the hypothesis on the common origin of the Paleo-Aleuts, Paleo-Eskimos, and the Indians from the northwestern North America, whose direct ancestors survived in Beringian/southwestern Alaskan coastal refugia during the late Ice Age. More... »

PAGES

1453-1460

Journal

TITLE

Russian Journal of Genetics

ISSUE

12

VOLUME

39

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:ruge.0000009163.03711.95

DOI

http://dx.doi.org/10.1023/b:ruge.0000009163.03711.95

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032055634


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