Association between diarrhea and quality of life in HIV-infected patients receiving highly active antiretroviral therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-02

AUTHORS

Andrea Tramarin, Nicoletta Parise, Stefano Campostrini, Donald D. Yin, Maarten J. Postma, Ramon Lyu, Roberta Grisetti, Amedeo Capetti, Anna Maria Cattelan, Maria Teresa Di Toro, Antonio Mastroianni, Elena Pignattari, Valeria Mondardini, Guido Calleri, Enzo Raise, Fabrizio Starace

ABSTRACT

Diarrhea is a common symptom that many HIV patients experience either as a consequence of HIV infection or of highly active antiretroviral therapy (HAART). A multicenter, prospective observational study was conducted in 11 AIDS clinics in Italy to determine the effect of diarrhea on health-related quality of life among patients receiving HAART. The study enrolled 100 consecutive HIV positive patients who had diarrhea while on HAART. For each enrolled patient a control patient with matching disease stage who did not have diarrhea was identified using existing data from another prospective observational study conducted in 34 AIDS clinics (including the 11 in current study). Quality of life was measured by MOS-HIV Health Survey (MOS-HIV). Paired t-test and multiple regression analysis were used to compare the quality of life among patients with and without diarrhea. Mean patient age was 40 +/- 7 years; 69% were male. Mean CD4 cell count was 342 +/- 239 cells/mm3; 59% had AIDS. Of the cases, 49 patients had severe diarrhea (> 5 bowel movements or > 3 watery per day) and 46 patients had moderate diarrhea (3-5 bowel movements). Compared to matched control patients, cases experiencing diarrhea while on HAART had significantly lower MOS-HIV scores in all domains. The significant adverse effect of diarrhea on quality of life should be considered when choosing the appropriate antiretroviral drugs regimen. More... »

PAGES

243-250

References to SciGraph publications

  • 2000-04. Cost Effectiveness of Combination HIV Therapy in PHARMACOECONOMICS
  • 1996-09. Diarrhea and quality of life in ambulatory HIV-infected patients in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/b:qure.0000015282.24774.36

    DOI

    http://dx.doi.org/10.1023/b:qure.0000015282.24774.36

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023754618

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15058804


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/b:qure.0000015282.24774.36'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:qure.0000015282.24774.36'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:qure.0000015282.24774.36'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/b:qure.0000015282.24774.36'


     

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