Ontology type: schema:ScholarlyArticle
2003-12
AUTHORSL. A. Dailey, E. Kleemann, M. Wittmar, T. Gessler, T. Schmehl, C. Roberts, W. Seeger, T. Kissel
ABSTRACTPURPOSE: This study describes the development of surfactant-free, biodegradable nanoparticle systems with varying physicochemical properties and their suitability for pulmonary application via nebulization. METHODS: Nanoparticle suspensions were formulated from the branched polyester, diethylaminopropyl amine-poly(vinyl alcohol)-grafted-poly(lactide-co-glycolide) (DEAPA-PVAL-g-PLGA) alone, as well as with increasing amounts of carboxymethyl cellulose (CMC). Particle size, zeta potential, turbidity, and morphology (atomic force microscopy) were characterized. Three formulations were chosen for further study: Cationic nanoparticles without CMC, cationic nanoparticles with CMC, and anionic nanoparticles with an excess of CMC. Nanoparticle degradation was characterized, as well as stability during nebulization. Nanoparticle-cell interactions were investigated and quantified using confocal laser scanning microscopy and fluorescence spectrometry. RESULTS: Nanoparticles ranged in size from 70-250 nm and displayed zeta potentials of +58.9 to -46.6 mV. Anionic nanoparticles showed the highest stability during nebulization. The degradation rate of each nanoparticle formulation decreased with increasing amounts of CMC. Cell association was highest among cationic nanoparticles (57% and 30%, respectively), although these were not internalized. Despite a lower rate of cell association (3%), anionic nanoparticles were internalized by A549 cells. CONCLUSIONS: Surfactant-free nanoparticles from DEAPA-PVAL-g-PLGA are versatile drug delivery systems; however, only the anionic formulations investigated were proven suitable for aerosol therapy. More... »
PAGES2011-2020
http://scigraph.springernature.com/pub.10.1023/b:pham.0000008051.94834.10
DOIhttp://dx.doi.org/10.1023/b:pham.0000008051.94834.10
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1044829576
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14725368
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Chemistry (incl. Structural)",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aerosols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biotransformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carboxymethylcellulose Sodium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemistry, Pharmaceutical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Delivery Systems",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Stability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lactic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microscopy, Atomic Force",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microscopy, Confocal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microspheres",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nephelometry and Turbidimetry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Particle Size",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pharmaceutic Aids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyesters",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyglactin 910",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyglycolic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyvinyl Alcohol",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spectrometry, Fluorescence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Suspensions",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Philipp University of Marburg",
"id": "https://www.grid.ac/institutes/grid.10253.35",
"name": [
"Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35037, Marburg, Germany"
],
"type": "Organization"
},
"familyName": "Dailey",
"givenName": "L. A.",
"id": "sg:person.0617250173.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617250173.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Giessen",
"id": "https://www.grid.ac/institutes/grid.8664.c",
"name": [
"Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35037, Marburg, Germany",
"Department of Internal Medicine, Justus Liebig University, 35392, Giessen, Germany"
],
"type": "Organization"
},
"familyName": "Kleemann",
"givenName": "E.",
"id": "sg:person.0724652702.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724652702.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Philipp University of Marburg",
"id": "https://www.grid.ac/institutes/grid.10253.35",
"name": [
"Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35037, Marburg, Germany"
],
"type": "Organization"
},
"familyName": "Wittmar",
"givenName": "M.",
"id": "sg:person.01326064353.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326064353.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Giessen",
"id": "https://www.grid.ac/institutes/grid.8664.c",
"name": [
"Department of Internal Medicine, Justus Liebig University, 35392, Giessen, Germany"
],
"type": "Organization"
},
"familyName": "Gessler",
"givenName": "T.",
"id": "sg:person.0767100555.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767100555.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Giessen",
"id": "https://www.grid.ac/institutes/grid.8664.c",
"name": [
"Department of Internal Medicine, Justus Liebig University, 35392, Giessen, Germany"
],
"type": "Organization"
},
"familyName": "Schmehl",
"givenName": "T.",
"id": "sg:person.0720765355.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720765355.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Advanced Drug Delivery Group and Laboratory of Biophysics and Surface Analysis, School of Pharaceutical Science, University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Roberts",
"givenName": "C.",
"id": "sg:person.01035336303.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035336303.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Giessen",
"id": "https://www.grid.ac/institutes/grid.8664.c",
"name": [
"Department of Internal Medicine, Justus Liebig University, 35392, Giessen, Germany"
],
"type": "Organization"
},
"familyName": "Seeger",
"givenName": "W.",
"id": "sg:person.01107460041.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107460041.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Philipp University of Marburg",
"id": "https://www.grid.ac/institutes/grid.10253.35",
"name": [
"Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35037, Marburg, Germany"
],
"type": "Organization"
},
"familyName": "Kissel",
"givenName": "T.",
"id": "sg:person.01327274201.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327274201.86"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.2131/jts.25.49",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002084050"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.276.5320.1868",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003295975"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00159-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003971593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00159-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003971593"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1019833822997",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005494101",
"https://doi.org/10.1023/a:1019833822997"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/taap.2001.9240",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005797921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0032-3861(97)10077-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008493533"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/pl00000304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010661947",
"https://doi.org/10.1007/pl00000304"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00101-002-0370-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011202758",
"https://doi.org/10.1007/s00101-002-0370-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0142-9612(02)00182-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018358595"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-3659(00)00201-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024432952"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(98)00074-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025778021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.bioeng.4.100101.132311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026398040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.182233999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040868895"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0032-3861(99)00710-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042939636"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043677884",
"https://doi.org/10.1038/nrd836"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043677884",
"https://doi.org/10.1038/nrd836"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-3659(01)00231-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044201799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jac/48.3.431",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045908927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-3659(02)00370-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047052848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-3659(02)00370-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047052848"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1012296604685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049038373",
"https://doi.org/10.1023/a:1012296604685"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm015609m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055219589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm015609m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055219589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/089426800418613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059201135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1615/critrevtherdrugcarriersyst.v12.i2-3.20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068133161"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1615/critrevtherdrugcarriersyst.v19.i45.40",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068133281"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.6.1839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074783938"
],
"type": "CreativeWork"
}
],
"datePublished": "2003-12",
"datePublishedReg": "2003-12-01",
"description": "PURPOSE: This study describes the development of surfactant-free, biodegradable nanoparticle systems with varying physicochemical properties and their suitability for pulmonary application via nebulization.\nMETHODS: Nanoparticle suspensions were formulated from the branched polyester, diethylaminopropyl amine-poly(vinyl alcohol)-grafted-poly(lactide-co-glycolide) (DEAPA-PVAL-g-PLGA) alone, as well as with increasing amounts of carboxymethyl cellulose (CMC). Particle size, zeta potential, turbidity, and morphology (atomic force microscopy) were characterized. Three formulations were chosen for further study: Cationic nanoparticles without CMC, cationic nanoparticles with CMC, and anionic nanoparticles with an excess of CMC. Nanoparticle degradation was characterized, as well as stability during nebulization. Nanoparticle-cell interactions were investigated and quantified using confocal laser scanning microscopy and fluorescence spectrometry.\nRESULTS: Nanoparticles ranged in size from 70-250 nm and displayed zeta potentials of +58.9 to -46.6 mV. Anionic nanoparticles showed the highest stability during nebulization. The degradation rate of each nanoparticle formulation decreased with increasing amounts of CMC. Cell association was highest among cationic nanoparticles (57% and 30%, respectively), although these were not internalized. Despite a lower rate of cell association (3%), anionic nanoparticles were internalized by A549 cells.\nCONCLUSIONS: Surfactant-free nanoparticles from DEAPA-PVAL-g-PLGA are versatile drug delivery systems; however, only the anionic formulations investigated were proven suitable for aerosol therapy.",
"genre": "research_article",
"id": "sg:pub.10.1023/b:pham.0000008051.94834.10",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1094644",
"issn": [
"0724-8741",
"1573-904X"
],
"name": "Pharmaceutical Research",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"name": "Surfactant-Free, Biodegradable Nanoparticles for Aerosol Therapy Based on the Branched Polyesters, DEAPA-PVAL-g-PLGA",
"pagination": "2011-2020",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"d589a483bcbd74da1994fdb00df4f0302215c34bcc0e60cff5fe255e18a148ca"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"14725368"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8406521"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1023/b:pham.0000008051.94834.10"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1044829576"
]
}
],
"sameAs": [
"https://doi.org/10.1023/b:pham.0000008051.94834.10",
"https://app.dimensions.ai/details/publication/pub.1044829576"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:30",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000507.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1023%2FB%3APHAM.0000008051.94834.10"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/b:pham.0000008051.94834.10'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:pham.0000008051.94834.10'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:pham.0000008051.94834.10'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/b:pham.0000008051.94834.10'
This table displays all metadata directly associated to this object as RDF triples.
282 TRIPLES
21 PREDICATES
73 URIs
41 LITERALS
29 BLANK NODES