Increased Formation of Reactive Oxygen Species, but No Changes in Glutathione Peroxidase Activity, in Striata of Mice Transgenic for the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-04

AUTHORS

Francisca Pérez-Severiano, Abel Santamaría, José Pedraza-Chaverri, Omar N. Medina-Campos, Camilo Ríos, José Segovia

ABSTRACT

The formation of reactive oxygen species (ROS) and the activities of the antioxidant enzymes glutathione peroxidase (GPx) and catalase (CAT) were measured as a function of age in the striatum of mice transgenic for the Huntington's disease (HD) mutation. Striata from R6/1 transgenic male mice were dissected at different ages (11, 19, and 35 weeks). The amount of dichlorofluorescein (DCF), an index of ROS formation, was significantly increased in R6/1 mice at all ages tested, whereas GPx activity remained unchanged when compared with wild-type control animals in all groups evaluated. CAT activity was very low, just above detection in the striata of both control and transgenic mice. Nineteen and 35-week-old R6/1 mice also developed feet clasping behavior, but only 35-week-old animals showed body weight loss. Our findings support an active role of free radicals in the onset and progression of the neurological phenotype of R6/1 mice. We suggest that changes in ROS formation are due to an age-related increased propensity of the striatum of transgenic animals to generate oxygen radicals as a response to the evolving pathological conditions. More... »

PAGES

729-733

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:nere.0000018843.83770.4b

DOI

http://dx.doi.org/10.1023/b:nere.0000018843.83770.4b

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004353255

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15098934


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