In vitro selection of non-crosshybridizing oligonucleotides for computation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12

AUTHORS

Hong Bi, Junghuei Chen, Russell Deaton, Max Garzon, Harvey Rubin, David Harlan Wood

ABSTRACT

Since they minimize errors from cross-hybridizations, DNA oligonucleotides that annealas designed are beneficial to DNA computing. By in vitro selection, huge libraries of non-crosshybridizing oligonucleotides might be evolved in the test tube. As a first step, a fitness function corresponding to non-crosshybridization was based upon the duplex stability of randomly matched oligonucleotides. By melting pairs that have a low thermal stability, a protocol based on DNA polymerization selectively amplifies maximally mismatched oligonucleotides over those that were more closely matched. Experiments confirmed this property of the protocol, and in addition, a reaction temperature window was identified in which discrimination between matched and mismatched might be obtained. The protocol was iterated on a set of random starting material, and there was evidence that non-crosshybridizing libraries were in fact being created. These results are a step toward practical manufacture of very large libraries of non-crosshybridizing oligonucleotides in the test tube. More... »

PAGES

417-426

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:naco.0000006772.32105.46

DOI

http://dx.doi.org/10.1023/b:naco.0000006772.32105.46

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038495136


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