Angiogenic strategy for human ischemic heart disease: Brief overview View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

Shoji Fukuda, Shinpei Yoshii, Shigeaki Kaga, Masahiko Matsumoto, Kiyotaka Kugiyama, Nilanjana Maulik

ABSTRACT

In the Western World ischemic coronary disease is the leading cause of morbidity and mortality. Therapeutic approaches mostly aim to restore flow to a localized segment by angioplasty or bypass surgery. Therapeutic angiogenesis and or arteriogenesis describes a strategy where blood vessel formation is induced for the purposes of treating and/or preventing ischemic disease. At present, at least 17 clinical trials of myocardial angiogenesis have been presented involving over 900 patients. Therapeutic angiogenesis makes use of the administration of angiogenic growth factor protein or gene to promote the development of endogenous collateral vessels in ischemic myocardium. Most recently, interest has grown in the potential angiogenesis effects of cell therapy--such as autologous bone marrow cells or cultured stem cells--and there are now several groups initiating phase I/II trials in this area. More... »

PAGES

143-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:mcbi.0000044383.01785.05

DOI

http://dx.doi.org/10.1023/b:mcbi.0000044383.01785.05

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010547318

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15544043


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