Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib (`Iressa', ZD1839) View Full Text


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Article Info

DATE

2004-05

AUTHORS

Stephen Hiscox, Liam Morgan, Denise Barrow, Carol Dutkowski, Alan Wakeling, Robert I. Nicholson

ABSTRACT

Despite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to display autocrine epidermal growth factor receptor (EGFR) signalling, we assessed how resistance might modulate their metastatic phenotype in vitro, as metastatic disease is the single most important factor affecting the mortality of cancer patients. Furthermore, we investigated the effect of the EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib ('Iressa', ZD1839; AstraZeneca), on this behaviour. The acquisition of tamoxifen resistance in MCF7 cells was accompanied by a dramatic and significant increase in their invasive and motile nature. The affinity of these cells for matrix components was also enhanced. Inhibition of EGFR signalling with gefitinib reduced both basal and TGF-alpha-stimulated invasion and motility and reduced cell-matrix adhesion. In conclusion, we demonstrate here that resistance to tamoxifen in breast cancer cells is accompanied by a significant increase in their basal motile and invasive activity, properties associated with increased metastatic potential. Inhibition of EGFR signalling by gefitinib significantly inhibited cell motility and invasion thus suggesting a role for the EGF receptor in the aggressive phenotype of tamoxifen-resistant breast cancer cells. More... »

PAGES

201-212

References to SciGraph publications

  • 2000-12. ZD1839 (‘Iressa’)1,2 as an Anticancer Agent in DRUGS
  • 1999-08. Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours in VIRCHOWS ARCHIV
  • 2000-04. Tyrosine Kinase Inhibitors Targeted to the Epidermal Growth Factor Receptor Subfamily in DRUGS
  • 2001-07. Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion in ONCOGENE
  • 1992-11. Quantitative Determination of EGF-R During Epidermal Wound Healing in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1994-01. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-02. Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4 in BREAST CANCER RESEARCH AND TREATMENT
  • 1998-12. Growth Factor Network Disruption in Prostate Cancer Progression in CANCER AND METASTASIS REVIEWS
  • 2002-02. Endocrine-responsive breast cancer and strategies for combating resistance in NATURE REVIEWS CANCER
  • 1993-05. Epidermal Growth Factor and Insulin-Like Growth Factor I Enhance Keratinocyte Migration in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1999-05. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-α in human prostate cancer cells in BRITISH JOURNAL OF CANCER
  • 1978-10. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α in NATURE
  • 1994-01. Mechanisms of tamoxifen resistance in BREAST CANCER RESEARCH AND TREATMENT
  • 1992-06. Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line in BRITISH JOURNAL OF CANCER
  • 2001-10. Adhesion, actin cytoskeleton organisation and the spreading of colon adenocarcinoma cells induced by EGF are mediated by α2β1 integrin low clustering through focal adhesion kinase in HISTOCHEMISTRY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d

    DOI

    http://dx.doi.org/10.1023/b:clin.0000037697.76011.1d

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034162687

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15387370


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    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'

    RDF/XML is a standard XML format for linked data.

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