Ontology type: schema:ScholarlyArticle
2004-05
AUTHORSStephen Hiscox, Liam Morgan, Denise Barrow, Carol Dutkowski, Alan Wakeling, Robert I. Nicholson
ABSTRACTDespite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to display autocrine epidermal growth factor receptor (EGFR) signalling, we assessed how resistance might modulate their metastatic phenotype in vitro, as metastatic disease is the single most important factor affecting the mortality of cancer patients. Furthermore, we investigated the effect of the EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib ('Iressa', ZD1839; AstraZeneca), on this behaviour. The acquisition of tamoxifen resistance in MCF7 cells was accompanied by a dramatic and significant increase in their invasive and motile nature. The affinity of these cells for matrix components was also enhanced. Inhibition of EGFR signalling with gefitinib reduced both basal and TGF-alpha-stimulated invasion and motility and reduced cell-matrix adhesion. In conclusion, we demonstrate here that resistance to tamoxifen in breast cancer cells is accompanied by a significant increase in their basal motile and invasive activity, properties associated with increased metastatic potential. Inhibition of EGFR signalling by gefitinib significantly inhibited cell motility and invasion thus suggesting a role for the EGF receptor in the aggressive phenotype of tamoxifen-resistant breast cancer cells. More... »
PAGES201-212
http://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d
DOIhttp://dx.doi.org/10.1023/b:clin.0000037697.76011.1d
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1034162687
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15387370
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Hormonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Adhesion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microscopy, Fluorescence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quinazolines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tamoxifen",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "Hiscox",
"givenName": "Stephen",
"id": "sg:person.0624625166.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624625166.51"
],
"type": "Person"
},
{
"familyName": "Morgan",
"givenName": "Liam",
"id": "sg:person.0716555102.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716555102.37"
],
"type": "Person"
},
{
"familyName": "Barrow",
"givenName": "Denise",
"id": "sg:person.01277511160.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277511160.33"
],
"type": "Person"
},
{
"familyName": "Dutkowski",
"givenName": "Carol",
"type": "Person"
},
{
"familyName": "Wakeling",
"givenName": "Alan",
"id": "sg:person.01272370317.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272370317.38"
],
"type": "Person"
},
{
"familyName": "Nicholson",
"givenName": "Robert I.",
"id": "sg:person.0670333460.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1083/jcb.148.2.385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002474481"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1992.182",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003127763",
"https://doi.org/10.1038/bjc.1992.182"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1992.182",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003127763",
"https://doi.org/10.1038/bjc.1992.182"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1006348317841",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004186226",
"https://doi.org/10.1023/a:1006348317841"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0215(20001120)89:6<484::aid-ijc3>3.0.co;2-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009425575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1357-2725(99)00015-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010938376"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(01)00231-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011723495"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200109060",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015145867"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/275458a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016490252",
"https://doi.org/10.1038/275458a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/275458a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016490252",
"https://doi.org/10.1038/275458a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/275458a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016490252",
"https://doi.org/10.1038/275458a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0304-3835(99)00167-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016838007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m205002200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019015445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000068621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021075401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-4827(02)00098-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022717193"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci119309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023419231"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026241132",
"https://doi.org/10.1007/bf00666187"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026241132",
"https://doi.org/10.1007/bf00666187"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/1523-1747.ep12472297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027948297",
"https://doi.org/10.1111/1523-1747.ep12472297"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004180100324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032461293",
"https://doi.org/10.1007/s004180100324"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15419060214147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032586649"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-200059040-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032968092",
"https://doi.org/10.2165/00003495-200059040-00003"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-200059040-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032968092",
"https://doi.org/10.2165/00003495-200059040-00003"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc721",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033032980",
"https://doi.org/10.1038/nrc721"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc721",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033032980",
"https://doi.org/10.1038/nrc721"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2002-220620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033760962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5347(05)68354-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034075575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0215(19990505)81:3<471::aid-ijc23>3.0.co;2-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034078497"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/028418602753669481",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035457924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/1523-1747.ep12668143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037830513",
"https://doi.org/10.1111/1523-1747.ep12668143"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004280050407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038065103",
"https://doi.org/10.1007/s004280050407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/90.11.824",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040387888"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043332790",
"https://doi.org/10.1038/sj.onc.1204541"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043332790",
"https://doi.org/10.1038/sj.onc.1204541"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-4827(03)00065-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044826957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-4827(03)00065-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044826957"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1006114527274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045633970",
"https://doi.org/10.1023/a:1006114527274"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.119.4.893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046380492"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046684356",
"https://doi.org/10.1007/bf00666205"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046684356",
"https://doi.org/10.1007/bf00666205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.21.12.4016-4031.2001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048095713"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-200060001-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049769296",
"https://doi.org/10.2165/00003495-200060001-00004"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-200060001-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049769296",
"https://doi.org/10.2165/00003495-200060001-00004"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6690407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050582217",
"https://doi.org/10.1038/sj.bjc.6690407"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6690407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050582217",
"https://doi.org/10.1038/sj.bjc.6690407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(98)00224-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051726024"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-5002(00)00116-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052701692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8052857",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062652101"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1064242887",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074463786",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074870446",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075175856",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075185054",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075271078",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082456550",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082545478",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082572823",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083013370",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083187504",
"type": "CreativeWork"
}
],
"datePublished": "2004-05",
"datePublishedReg": "2004-05-01",
"description": "Despite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to display autocrine epidermal growth factor receptor (EGFR) signalling, we assessed how resistance might modulate their metastatic phenotype in vitro, as metastatic disease is the single most important factor affecting the mortality of cancer patients. Furthermore, we investigated the effect of the EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib ('Iressa', ZD1839; AstraZeneca), on this behaviour. The acquisition of tamoxifen resistance in MCF7 cells was accompanied by a dramatic and significant increase in their invasive and motile nature. The affinity of these cells for matrix components was also enhanced. Inhibition of EGFR signalling with gefitinib reduced both basal and TGF-alpha-stimulated invasion and motility and reduced cell-matrix adhesion. In conclusion, we demonstrate here that resistance to tamoxifen in breast cancer cells is accompanied by a significant increase in their basal motile and invasive activity, properties associated with increased metastatic potential. Inhibition of EGFR signalling by gefitinib significantly inhibited cell motility and invasion thus suggesting a role for the EGF receptor in the aggressive phenotype of tamoxifen-resistant breast cancer cells.",
"genre": "research_article",
"id": "sg:pub.10.1023/b:clin.0000037697.76011.1d",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1094856",
"issn": [
"0262-0898",
"1573-7276"
],
"name": "Clinical & Experimental Metastasis",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"name": "Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib (`Iressa', ZD1839)",
"pagination": "201-212",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"a2bd6d48aca03c974b5a637572928710a5612e586ac1ffcbb25444132a404f56"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15387370"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8409970"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1023/b:clin.0000037697.76011.1d"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034162687"
]
}
],
"sameAs": [
"https://doi.org/10.1023/b:clin.0000037697.76011.1d",
"https://app.dimensions.ai/details/publication/pub.1034162687"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000506.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1023%2FB%3ACLIN.0000037697.76011.1d"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/b:clin.0000037697.76011.1d'
This table displays all metadata directly associated to this object as RDF triples.
286 TRIPLES
21 PREDICATES
88 URIs
32 LITERALS
20 BLANK NODES