Increased Constitutive Activity of PKB/Akt in Tamoxifen Resistant Breast Cancer MCF-7 Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

Nicola J. Jordan, Julia M.W. Gee, Denise Barrow, Alan E. Wakeling, Robert I. Nicholson

ABSTRACT

The tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line has been used as a model to identify the signalling pathways that enable resistant cancer cells to grow independently of steroid hormones. In TAM-R cells, peptide growth factor signalling pathways appear to be important in modified cell behaviour, growth and survival. The PI3 kinase signalling components Akt1 and Akt2 are expressed at similar levels by both parental wild-type MCF-7 and TAM-R cells, but Akt1 phosphorylation is significantly increased in TAM-R cells grown under basal conditions. High levels of basal Akt, GSK3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI3 kinase inhibitor, LY 294002. The ligands for the EGFR/erbB1 receptor, EGF (epidermal growth factor) and TGF alpha (transforming growth factor- alpha ) demonstrate an increased ability to activate Akt in TAM-R compared with parental MCF-7 cells and it is proposed that the preferred autocrine or paracrine activation of Akt occurs via the erbB heterodimer EGFR/erbB2 in TAM-R cells. Akt phosphorylation is reduced by gefitinib ("Iressa"/ZD1839). The results suggest that the PI3 kinase pathway plays a role in proliferation of TAM-R cells and is important in the increased EGF induced membrane ruffling detected in the resistant cells. Increased Akt1 activation may contribute to the aggressive phenotype of tamoxifen resistant ER (oestrogen receptor) positive breast cancers. More... »

PAGES

167-180

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47

DOI

http://dx.doi.org/10.1023/b:brea.0000041623.21338.47

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015249151

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15377841


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tamoxifen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK, Tel.:"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jordan", 
        "givenName": "Nicola J.", 
        "id": "sg:person.0745061654.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745061654.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK, Tel.:"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gee", 
        "givenName": "Julia M.W.", 
        "id": "sg:person.012457220672.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012457220672.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.417815.e", 
          "name": [
            "AstraZeneca Pharmaceuticals, Mereside, Macclesfield, Cheshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barrow", 
        "givenName": "Denise", 
        "id": "sg:person.01277511160.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277511160.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK, Tel.:"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakeling", 
        "givenName": "Alan E.", 
        "id": "sg:person.01272370317.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272370317.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK, Tel.:"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicholson", 
        "givenName": "Robert I.", 
        "id": "sg:person.0670333460.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000163918", 
          "https://doi.org/10.1038/nm761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000163918", 
          "https://doi.org/10.1038/nm761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)01434-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001957153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003127763", 
          "https://doi.org/10.1038/bjc.1992.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003127763", 
          "https://doi.org/10.1038/bjc.1992.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.9.5042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007585553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(99)00015-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010938376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(06)00122-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014000323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017060329", 
          "https://doi.org/10.1038/sj.bjc.6600126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017060329", 
          "https://doi.org/10.1038/sj.bjc.6600126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.6.3550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019691533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019753883", 
          "https://doi.org/10.1186/bcr569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(200006)183:3<301::aid-jcp2>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020870543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010840200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021165334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.8.3636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021669136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(02)00193-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025506058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026241132", 
          "https://doi.org/10.1007/bf00666187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026241132", 
          "https://doi.org/10.1007/bf00666187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.11.8027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026934719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.01-0198com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029917202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m305226200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031841084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910640412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032190816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20000815)87:4<487::aid-ijc5>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032581199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20000815)87:4<487::aid-ijc5>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032581199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2002-220620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033760962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:clin.0000037697.76011.1d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034162687", 
          "https://doi.org/10.1023/b:clin.0000037697.76011.1d"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.6.3741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035636515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.17.6247-6260.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035945717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.48.30491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036708498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.31.21528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038165223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61714-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038820521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0080175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0080175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.13.3159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040473291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1999.1144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041483206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1999.4690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041937080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.14.5034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042871937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045674792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1359-6101(96)00016-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046717522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.19.9267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048848467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.50.31515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050619363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051386685", 
          "https://doi.org/10.1038/sj.onc.1203598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051386685", 
          "https://doi.org/10.1038/sj.onc.1203598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90262-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051800098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(03)00562-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051809455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-031206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2003-0705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064246261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.141.12.7836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.142.7.8259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064284455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-2-10-886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074859834", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074865682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074889449", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074896181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075087964", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075203265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075214751", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075221325", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075298831", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075330699", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079038919", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082944023", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347332", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-09", 
    "datePublishedReg": "2004-09-01", 
    "description": "The tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line has been used as a model to identify the signalling pathways that enable resistant cancer cells to grow independently of steroid hormones. In TAM-R cells, peptide growth factor signalling pathways appear to be important in modified cell behaviour, growth and survival. The PI3 kinase signalling components Akt1 and Akt2 are expressed at similar levels by both parental wild-type MCF-7 and TAM-R cells, but Akt1 phosphorylation is significantly increased in TAM-R cells grown under basal conditions. High levels of basal Akt, GSK3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI3 kinase inhibitor, LY 294002. The ligands for the EGFR/erbB1 receptor, EGF (epidermal growth factor) and TGF alpha (transforming growth factor- alpha ) demonstrate an increased ability to activate Akt in TAM-R compared with parental MCF-7 cells and it is proposed that the preferred autocrine or paracrine activation of Akt occurs via the erbB heterodimer EGFR/erbB2 in TAM-R cells. Akt phosphorylation is reduced by gefitinib (\"Iressa\"/ZD1839). The results suggest that the PI3 kinase pathway plays a role in proliferation of TAM-R cells and is important in the increased EGF induced membrane ruffling detected in the resistant cells. Increased Akt1 activation may contribute to the aggressive phenotype of tamoxifen resistant ER (oestrogen receptor) positive breast cancers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/b:brea.0000041623.21338.47", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "87"
      }
    ], 
    "name": "Increased Constitutive Activity of PKB/Akt in Tamoxifen Resistant Breast Cancer MCF-7 Cells", 
    "pagination": "167-180", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "48a75d9df85a454c86e686c52ec4436878895bd21e949f8d830267ba71ec3360"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15377841"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/b:brea.0000041623.21338.47"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015249151"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/b:brea.0000041623.21338.47", 
      "https://app.dimensions.ai/details/publication/pub.1015249151"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FB%3ABREA.0000041623.21338.47"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/b:brea.0000041623.21338.47'


 

This table displays all metadata directly associated to this object as RDF triples.

330 TRIPLES      21 PREDICATES      102 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/b:brea.0000041623.21338.47 schema:about N209c62b44d974d61aa2e9158ffc1148d
2 N2eafb49246804c6d8bbe2b04d1e7d778
3 N4d4066cc6d894e6c97489e44c1ad6843
4 N6d35156283ca407f803555a9f170e144
5 N89d8bc542cd845a0a2a483dbd9e12381
6 N9002d9f473f74f358acc1959894b25a0
7 N9c83f4e92a1d46faa1792fd5f7adf0e3
8 Nb51cd08dba214a77a6f8107da73b7fa4
9 Nb738755f191a47c8a354b8b1ba0c0e79
10 Nc5cda628db7540519da6b45898e7d4fa
11 Nc7ce4cdbf6e44e6f8fd7f255f9e9a777
12 Nda50f3158ea147ca816ffc0cfa1a65e4
13 Ndaffdc46cb034312b5b0aea1e6d4ebd0
14 Ndf99cf6dfa2349fbbb04bf7361e13c6c
15 Ne0f5bab9e75c488b8987834e0ac3aacd
16 Nf8aef719d85e45c4adac387c39c61e02
17 Nfc007b7414444d6888414e711270809b
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N264ab366cc3248edbd1dc91487702c69
21 schema:citation sg:pub.10.1007/bf00666187
22 sg:pub.10.1023/b:clin.0000037697.76011.1d
23 sg:pub.10.1038/bjc.1992.182
24 sg:pub.10.1038/nm761
25 sg:pub.10.1038/sj.bjc.6600126
26 sg:pub.10.1038/sj.onc.1203598
27 sg:pub.10.1186/bcr569
28 https://app.dimensions.ai/details/publication/pub.1074859834
29 https://app.dimensions.ai/details/publication/pub.1074865682
30 https://app.dimensions.ai/details/publication/pub.1074889449
31 https://app.dimensions.ai/details/publication/pub.1074896181
32 https://app.dimensions.ai/details/publication/pub.1075087964
33 https://app.dimensions.ai/details/publication/pub.1075203265
34 https://app.dimensions.ai/details/publication/pub.1075214751
35 https://app.dimensions.ai/details/publication/pub.1075221325
36 https://app.dimensions.ai/details/publication/pub.1075298831
37 https://app.dimensions.ai/details/publication/pub.1075330699
38 https://app.dimensions.ai/details/publication/pub.1079038919
39 https://app.dimensions.ai/details/publication/pub.1082944023
40 https://app.dimensions.ai/details/publication/pub.1083347332
41 https://doi.org/10.1002/(sici)1097-4652(200006)183:3<301::aid-jcp2>3.0.co;2-w
42 https://doi.org/10.1002/1097-0215(20000815)87:4<487::aid-ijc5>3.0.co;2-j
43 https://doi.org/10.1002/ijc.2910640412
44 https://doi.org/10.1006/bbrc.1999.1144
45 https://doi.org/10.1006/excr.1999.4690
46 https://doi.org/10.1016/0277-5379(91)90262-c
47 https://doi.org/10.1016/1359-6101(96)00016-0
48 https://doi.org/10.1016/s0002-9440(10)61714-2
49 https://doi.org/10.1016/s0014-5793(03)00562-3
50 https://doi.org/10.1016/s0014-5793(99)01434-9
51 https://doi.org/10.1016/s0163-7258(02)00193-6
52 https://doi.org/10.1016/s0960-9822(06)00122-9
53 https://doi.org/10.1016/s1357-2725(99)00015-1
54 https://doi.org/10.1073/pnas.84.14.5034
55 https://doi.org/10.1073/pnas.89.19.9267
56 https://doi.org/10.1073/pnas.93.8.3636
57 https://doi.org/10.1073/pnas.95.9.5246
58 https://doi.org/10.1074/jbc.272.48.30491
59 https://doi.org/10.1074/jbc.272.50.31515
60 https://doi.org/10.1074/jbc.274.31.21528
61 https://doi.org/10.1074/jbc.275.11.8027
62 https://doi.org/10.1074/jbc.275.6.3741
63 https://doi.org/10.1074/jbc.m010840200
64 https://doi.org/10.1074/jbc.m305226200
65 https://doi.org/10.1093/emboj/19.13.3159
66 https://doi.org/10.1096/fj.01-0198com
67 https://doi.org/10.1128/mcb.14.6.3550
68 https://doi.org/10.1128/mcb.18.9.5042
69 https://doi.org/10.1128/mcb.22.17.6247-6260.2002
70 https://doi.org/10.1158/1078-0432.ccr-031206
71 https://doi.org/10.1210/en.2002-220620
72 https://doi.org/10.1210/en.2003-0705
73 https://doi.org/10.1210/endo.141.12.7836
74 https://doi.org/10.1210/endo.142.7.8259
75 https://doi.org/10.1210/mend-2-10-886
76 https://doi.org/10.1677/erc.0.0080175
77 schema:datePublished 2004-09
78 schema:datePublishedReg 2004-09-01
79 schema:description The tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line has been used as a model to identify the signalling pathways that enable resistant cancer cells to grow independently of steroid hormones. In TAM-R cells, peptide growth factor signalling pathways appear to be important in modified cell behaviour, growth and survival. The PI3 kinase signalling components Akt1 and Akt2 are expressed at similar levels by both parental wild-type MCF-7 and TAM-R cells, but Akt1 phosphorylation is significantly increased in TAM-R cells grown under basal conditions. High levels of basal Akt, GSK3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI3 kinase inhibitor, LY 294002. The ligands for the EGFR/erbB1 receptor, EGF (epidermal growth factor) and TGF alpha (transforming growth factor- alpha ) demonstrate an increased ability to activate Akt in TAM-R compared with parental MCF-7 cells and it is proposed that the preferred autocrine or paracrine activation of Akt occurs via the erbB heterodimer EGFR/erbB2 in TAM-R cells. Akt phosphorylation is reduced by gefitinib ("Iressa"/ZD1839). The results suggest that the PI3 kinase pathway plays a role in proliferation of TAM-R cells and is important in the increased EGF induced membrane ruffling detected in the resistant cells. Increased Akt1 activation may contribute to the aggressive phenotype of tamoxifen resistant ER (oestrogen receptor) positive breast cancers.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree false
83 schema:isPartOf N0881a018d52241f9a464847922879a29
84 N22b397a937e846438165e6598c76e1ae
85 sg:journal.1092777
86 schema:name Increased Constitutive Activity of PKB/Akt in Tamoxifen Resistant Breast Cancer MCF-7 Cells
87 schema:pagination 167-180
88 schema:productId N37f7e3de6d7142d9998f689939b522ea
89 N9ad59e0e4e07417798b61e28222fa01c
90 Nb3f2f3a642c348d7a7376c8167713350
91 Ne0b4dfbc01094a7c9ebbb625b5e70df0
92 Neecd5d737e014dd3aaeb956f3e520cee
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015249151
94 https://doi.org/10.1023/b:brea.0000041623.21338.47
95 schema:sdDatePublished 2019-04-11T00:14
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Nac5bd766d35e401e899f5f3387ce157a
98 schema:url http://link.springer.com/10.1023%2FB%3ABREA.0000041623.21338.47
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0881a018d52241f9a464847922879a29 schema:issueNumber 2
103 rdf:type schema:PublicationIssue
104 N0b88aa583689475891daf4e3a6568323 rdf:first sg:person.0670333460.58
105 rdf:rest rdf:nil
106 N1975c346881c4a57a6ca18794fb070c8 rdf:first sg:person.012457220672.07
107 rdf:rest Ncb67754cfac64adeb4feacded56772eb
108 N209c62b44d974d61aa2e9158ffc1148d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Proto-Oncogene Proteins
110 rdf:type schema:DefinedTerm
111 N22b397a937e846438165e6598c76e1ae schema:volumeNumber 87
112 rdf:type schema:PublicationVolume
113 N264ab366cc3248edbd1dc91487702c69 rdf:first sg:person.0745061654.61
114 rdf:rest N1975c346881c4a57a6ca18794fb070c8
115 N2eafb49246804c6d8bbe2b04d1e7d778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Epidermal Growth Factor
117 rdf:type schema:DefinedTerm
118 N37f7e3de6d7142d9998f689939b522ea schema:name doi
119 schema:value 10.1023/b:brea.0000041623.21338.47
120 rdf:type schema:PropertyValue
121 N4d4066cc6d894e6c97489e44c1ad6843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Tamoxifen
123 rdf:type schema:DefinedTerm
124 N5a88ab179d6744779bcc3cfc944798f1 rdf:first sg:person.01272370317.38
125 rdf:rest N0b88aa583689475891daf4e3a6568323
126 N6d35156283ca407f803555a9f170e144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Reverse Transcriptase Polymerase Chain Reaction
128 rdf:type schema:DefinedTerm
129 N89d8bc542cd845a0a2a483dbd9e12381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Breast Neoplasms
131 rdf:type schema:DefinedTerm
132 N9002d9f473f74f358acc1959894b25a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N9ad59e0e4e07417798b61e28222fa01c schema:name nlm_unique_id
136 schema:value 8111104
137 rdf:type schema:PropertyValue
138 N9c83f4e92a1d46faa1792fd5f7adf0e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Phosphorylation
140 rdf:type schema:DefinedTerm
141 Nac5bd766d35e401e899f5f3387ce157a schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nb3f2f3a642c348d7a7376c8167713350 schema:name pubmed_id
144 schema:value 15377841
145 rdf:type schema:PropertyValue
146 Nb51cd08dba214a77a6f8107da73b7fa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Signal Transduction
148 rdf:type schema:DefinedTerm
149 Nb738755f191a47c8a354b8b1ba0c0e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Protein-Tyrosine Kinases
151 rdf:type schema:DefinedTerm
152 Nc5cda628db7540519da6b45898e7d4fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Antineoplastic Agents, Hormonal
154 rdf:type schema:DefinedTerm
155 Nc7ce4cdbf6e44e6f8fd7f255f9e9a777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Drug Resistance, Neoplasm
157 rdf:type schema:DefinedTerm
158 Ncb67754cfac64adeb4feacded56772eb rdf:first sg:person.01277511160.33
159 rdf:rest N5a88ab179d6744779bcc3cfc944798f1
160 Nda50f3158ea147ca816ffc0cfa1a65e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Tumor Cells, Cultured
162 rdf:type schema:DefinedTerm
163 Ndaffdc46cb034312b5b0aea1e6d4ebd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Proto-Oncogene Proteins c-akt
165 rdf:type schema:DefinedTerm
166 Ndf99cf6dfa2349fbbb04bf7361e13c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Protein-Serine-Threonine Kinases
168 rdf:type schema:DefinedTerm
169 Ne0b4dfbc01094a7c9ebbb625b5e70df0 schema:name dimensions_id
170 schema:value pub.1015249151
171 rdf:type schema:PropertyValue
172 Ne0f5bab9e75c488b8987834e0ac3aacd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Receptors, Estrogen
174 rdf:type schema:DefinedTerm
175 Neecd5d737e014dd3aaeb956f3e520cee schema:name readcube_id
176 schema:value 48a75d9df85a454c86e686c52ec4436878895bd21e949f8d830267ba71ec3360
177 rdf:type schema:PropertyValue
178 Nf8aef719d85e45c4adac387c39c61e02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 Nfc007b7414444d6888414e711270809b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Phenotype
183 rdf:type schema:DefinedTerm
184 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
185 schema:name Biological Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
188 schema:name Biochemistry and Cell Biology
189 rdf:type schema:DefinedTerm
190 sg:journal.1092777 schema:issn 0167-6806
191 1573-7217
192 schema:name Breast Cancer Research and Treatment
193 rdf:type schema:Periodical
194 sg:person.012457220672.07 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
195 schema:familyName Gee
196 schema:givenName Julia M.W.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012457220672.07
198 rdf:type schema:Person
199 sg:person.01272370317.38 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
200 schema:familyName Wakeling
201 schema:givenName Alan E.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272370317.38
203 rdf:type schema:Person
204 sg:person.01277511160.33 schema:affiliation https://www.grid.ac/institutes/grid.417815.e
205 schema:familyName Barrow
206 schema:givenName Denise
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277511160.33
208 rdf:type schema:Person
209 sg:person.0670333460.58 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
210 schema:familyName Nicholson
211 schema:givenName Robert I.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58
213 rdf:type schema:Person
214 sg:person.0745061654.61 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
215 schema:familyName Jordan
216 schema:givenName Nicola J.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745061654.61
218 rdf:type schema:Person
219 sg:pub.10.1007/bf00666187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026241132
220 https://doi.org/10.1007/bf00666187
221 rdf:type schema:CreativeWork
222 sg:pub.10.1023/b:clin.0000037697.76011.1d schema:sameAs https://app.dimensions.ai/details/publication/pub.1034162687
223 https://doi.org/10.1023/b:clin.0000037697.76011.1d
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/bjc.1992.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003127763
226 https://doi.org/10.1038/bjc.1992.182
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nm761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000163918
229 https://doi.org/10.1038/nm761
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/sj.bjc.6600126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017060329
232 https://doi.org/10.1038/sj.bjc.6600126
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/sj.onc.1203598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051386685
235 https://doi.org/10.1038/sj.onc.1203598
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/bcr569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019753883
238 https://doi.org/10.1186/bcr569
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1074859834 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1074865682 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1074889449 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074896181 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1075087964 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1075203265 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1075214751 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1075221325 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1075298831 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1075330699 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1079038919 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082944023 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1083347332 schema:CreativeWork
253 https://doi.org/10.1002/(sici)1097-4652(200006)183:3<301::aid-jcp2>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1020870543
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/1097-0215(20000815)87:4<487::aid-ijc5>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1032581199
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/ijc.2910640412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032190816
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1006/bbrc.1999.1144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041483206
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1006/excr.1999.4690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041937080
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/0277-5379(91)90262-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1051800098
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/1359-6101(96)00016-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046717522
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0002-9440(10)61714-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038820521
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0014-5793(03)00562-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051809455
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0014-5793(99)01434-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001957153
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0163-7258(02)00193-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025506058
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0960-9822(06)00122-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014000323
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s1357-2725(99)00015-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010938376
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.84.14.5034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042871937
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.89.19.9267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848467
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.93.8.3636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021669136
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.95.9.5246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045674792
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1074/jbc.272.48.30491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036708498
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.272.50.31515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050619363
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.274.31.21528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038165223
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1074/jbc.275.11.8027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026934719
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1074/jbc.275.6.3741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035636515
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1074/jbc.m010840200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021165334
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m305226200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031841084
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/emboj/19.13.3159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040473291
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1096/fj.01-0198com schema:sameAs https://app.dimensions.ai/details/publication/pub.1029917202
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/mcb.14.6.3550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019691533
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1128/mcb.18.9.5042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007585553
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/mcb.22.17.6247-6260.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035945717
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/1078-0432.ccr-031206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224756
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1210/en.2002-220620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033760962
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1210/en.2003-0705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064246261
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1210/endo.141.12.7836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283526
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1210/endo.142.7.8259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064284455
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1210/mend-2-10-886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330137
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1677/erc.0.0080175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038939244
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.417815.e schema:alternateName AstraZeneca (United Kingdom)
326 schema:name AstraZeneca Pharmaceuticals, Mereside, Macclesfield, Cheshire, UK
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.5600.3 schema:alternateName Cardiff University
329 schema:name Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK, Tel.:
330 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...