Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

T. Kuster, T. Torresani, P. Kleinert, S. Durka, F. Neuheiser, C. W. Heizmann, H. Troxler

ABSTRACT

Electrospray ionization tandem mass spectrometry is a widely applied method for the analysis of acylcarnitines in blood samples spotted on filter paper cards (Guthrie cards). When the filter paper cards are contaminated by EMLA cream, highly intense signals at m/z 221 and 235 are detected under ESI-MS/MS conditions, monitoring for precursors of m/z 85. These signals correspond to the active ingredients prilocaine and lidocaine in EMLA and overlap with the signals from the isotopically labelled internal standards (2H3)propionyl carnitine and (2H3)butyrylcarnitine. This interference prevents the proper quantification of the two short-chain acylcarnitines when samples are analysed without derivatization. More... »

PAGES

707-709

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:boli.0000043024.08450.0c

DOI

http://dx.doi.org/10.1023/b:boli.0000043024.08450.0c

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003962347

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15669691


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