Apoptosis in P388 Leukemia Cells Induced by Specific Inhibitors of 5- and 12-Lipoxygenase and the Product of Cyclooxygenase, Prostaglandin E2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

O. E. Grichenko, V. V. Shaposhnikova, A. A. Kudryavtsev, Yu. N. Korystov

ABSTRACT

We studied the effect of specific inhibitors of 5- and 12-lipoxygenases as well as the product of cyclooxygenase activity, prostaglandin E2 , on proliferation and death of P388 leukemia cells. Inhibition of 5- and 12-lipoxygenases in the cells inhibits proliferation and induces apoptosis. The concentrations of baicalein, an inhibitor of 12-lipoxygenase, and AA861, an inhibitor of 5-lipoxygenase, causing a 50% death rate (LC50) proved to be the same, 50 μM. Excessive prostaglandin also inhibited proliferation of the cells and induced apoptosis. The LC50 for prostaglandin E2 was 4 μM. The obtained data suggest that apoptosis in P388 cells after lipoxygenase inhibition can be induced by both deficiency of lipoxygenase products and excess of prostaglandins in the cell. More... »

PAGES

221-225

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:bibu.0000030141.78751.90

DOI

http://dx.doi.org/10.1023/b:bibu.0000030141.78751.90

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052733134


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