Dolichol: a solar filter with UV-absorbing properties which can be photoenhanced View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

Antonella Sgarbossa, Francesco Lenci, Ettore Bergamini, Ranieri Bizzarri, Benedetta Cerbai, Francesca Signori, Zina Gori, Marco Maccheroni

ABSTRACT

Dolichol, the polyisoprenoid lipid found in all eukaryotic cells and suggested to represent a biomarker of aging, is inserted into cell membranes, also in tissues exposed to light such as the skin. A general question about its physiological role is whether dolichol may play the role of a natural barrier for the noxious components of solar radiation. In order to clarify this point, we established that dolichol is a component of human sebum and we performed an " in vitro " study of the effects of UV radiation on the spectral properties of dolichol in isopropanol. Our data clearly show that, following UV irradiation, the optical absorption spectrum of dolichol undergoes remarkable modifications below 400 nm: a significant, strongly dose-dependent, increase of the optical density around 320 nm and a minor, very slightly dose-dependent, raise of the absorbance at 250 nm. On the contrary, UV irradiation causes only minor changes in HPLC profiles and the formation of photooxidative products can be considered negligible in our experimental conditions. These results suggest that dolichol can be considered an innate, unusually efficient and promising UV screen for skin protection. More... »

PAGES

379-386

References to SciGraph publications

  • 1999-09. Ultraviolet Radiation Induced Signature Mutations in Photocarcinogenesis in JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS
  • 1998-08. Aging Versus Photoaging: Postulated Mechanisms and Effectors in JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS
  • 1989-07. Age-related changes in the lipid compositions of rat and human tissues in LIPIDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/b:bgen.0000006558.44482.a4

    DOI

    http://dx.doi.org/10.1023/b:bgen.0000006558.44482.a4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020342452

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14739709


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