Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

P. V. Sergeev, A. V. Semeikin, T. A. Fedotcheva, R. V. Samoilikov, A. V. Kamernitskii, I. S. Levina, V. M. Rzheznikov, G. S. Grinenko, Yu. N. Korystov, N. V. Ermakova, V. V. Shaposhnikova, N. L. Shimanovskii

ABSTRACT

The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10(-5) M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin. More... »

PAGES

460-463

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/b:bebm.0000017093.04390.a3

DOI

http://dx.doi.org/10.1023/b:bebm.0000017093.04390.a3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047029965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14968160


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