Antiinflammatory Effect of Lipocortin 1 in Experimental Arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-12

AUTHORS

Yuanhang Yang, Michelle Leech, Paul Hutchinson, Stephen R. Holdsworth, Eric F. Morand

ABSTRACT

The glucocorticoid-induced antiinflammatory protein lipocortin 1 is present in arthritic synovium but its ability to regulate joint inflammation has not previously been studied. We investigated the role of lipocortin 1 in the antiinflammatory activity of glucocorticoids in an acute arthritis model induced by intraarticular injection of carrageenan. Compared to control joints (0.09 +/- 0.08 x 10(6) synovial fluid cell count), carrageenan injected joints exhibited marked infiltration of PMN (10.2 +/- 0.7 x 10(6), p < 0.001). Both intraperitoneal (1.0 mg/kg) and intraarticular administration (5 micrograms) of dexamethasone (DEX) significantly suppressed arthritis severity (p < 0.001 and 0.005, respectively), and the effects of DEX were significantly prevented by intra-articular injection of antilipocortin 1 mAb (p < 0.05). Carrageenan arthritis was also significantly inhibited by intraarticular administration of the N-terminal lipocortin 1 peptide Ac2-26 at doses of 1 or 2 mg/kg (p < 0.01). Intraarticular injection antilipocortin 1 mAb in the absence of DEX also significantly exacerbated arthritis severity (p < 0.005). In vitro treatment of PMN with DEX was associated with significant inhibition of phagocytosis (p < 0.005) and reactive oxygen species (ROS) generation (p < 0.001). Antilipocortin 1 mAb significantly reduced the inhibitory effects of DEX (p < 0.01 and 0.005, respectively). These results demonstrate that lipocortin 1 mediates the effects of exogenous glucocorticoids on neutrophil migration in carrageenan-induced acute arthritis, exerts an endogenous antiinflammatory influence, and mediates glucocorticoid inhibition of neutrophil activation. More... »

PAGES

583-596

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1027330021479

DOI

http://dx.doi.org/10.1023/a:1027330021479

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026556366

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9429906


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Annexin A1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrageenan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Excipients", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Yuanhang", 
        "id": "sg:person.0716605557.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716605557.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leech", 
        "givenName": "Michelle", 
        "id": "sg:person.01303310332.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303310332.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutchinson", 
        "givenName": "Paul", 
        "id": "sg:person.01154000650.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154000650.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holdsworth", 
        "givenName": "Stephen R.", 
        "id": "sg:person.01131260677.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morand", 
        "givenName": "Eric F.", 
        "id": "sg:person.01136315644.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136315644.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000126651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003152568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(94)90402-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003273897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(94)90402-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003273897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(90)80564-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003279078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.7.2374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004984190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme.0.0090273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005484213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(90)90198-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005518355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(90)90198-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005518355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/clin.1995.1115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007263272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.8.3473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009107163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01966446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012083413", 
          "https://doi.org/10.1007/bf01966446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.1997.263-ce1154.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012712183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780390207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014478257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017718368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780390208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021094164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bb.23.060194.001205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021371271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780400104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022147597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(95)00238-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022987978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(95)00145-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023088562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(91)81293-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023257964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91445-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023700514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91445-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023700514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/375408a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024106872", 
          "https://doi.org/10.1038/375408a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.54.10.841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024772495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.1.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026326615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(94)80566-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026435238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027343186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780370601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029990974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01986574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031173250", 
          "https://doi.org/10.1007/bf01986574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01986574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031173250", 
          "https://doi.org/10.1007/bf01986574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.990130512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031411127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.990130512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031411127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199505183322008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031448544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040034773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1196-1259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041509450", 
          "https://doi.org/10.1038/nm1196-1259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780370209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042008167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1995.tb15916.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042993907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045727912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045985173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/icb.1994.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048016147", 
          "https://doi.org/10.1038/icb.1994.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.54.10.820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052146162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/32.9.816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060010559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.136.7.7789338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064280288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078374052", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079473236", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079555170", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082430734", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082467480", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082800784", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083144933", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-12", 
    "datePublishedReg": "1997-12-01", 
    "description": "The glucocorticoid-induced antiinflammatory protein lipocortin 1 is present in arthritic synovium but its ability to regulate joint inflammation has not previously been studied. We investigated the role of lipocortin 1 in the antiinflammatory activity of glucocorticoids in an acute arthritis model induced by intraarticular injection of carrageenan. Compared to control joints (0.09 +/- 0.08 x 10(6) synovial fluid cell count), carrageenan injected joints exhibited marked infiltration of PMN (10.2 +/- 0.7 x 10(6), p < 0.001). Both intraperitoneal (1.0 mg/kg) and intraarticular administration (5 micrograms) of dexamethasone (DEX) significantly suppressed arthritis severity (p < 0.001 and 0.005, respectively), and the effects of DEX were significantly prevented by intra-articular injection of antilipocortin 1 mAb (p < 0.05). Carrageenan arthritis was also significantly inhibited by intraarticular administration of the N-terminal lipocortin 1 peptide Ac2-26 at doses of 1 or 2 mg/kg (p < 0.01). Intraarticular injection antilipocortin 1 mAb in the absence of DEX also significantly exacerbated arthritis severity (p < 0.005). In vitro treatment of PMN with DEX was associated with significant inhibition of phagocytosis (p < 0.005) and reactive oxygen species (ROS) generation (p < 0.001). Antilipocortin 1 mAb significantly reduced the inhibitory effects of DEX (p < 0.01 and 0.005, respectively). These results demonstrate that lipocortin 1 mediates the effects of exogenous glucocorticoids on neutrophil migration in carrageenan-induced acute arthritis, exerts an endogenous antiinflammatory influence, and mediates glucocorticoid inhibition of neutrophil activation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1027330021479", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1084792", 
        "issn": [
          "0360-3997", 
          "1573-2576"
        ], 
        "name": "Inflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Antiinflammatory Effect of Lipocortin 1 in Experimental Arthritis", 
    "pagination": "583-596", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7e83d3560fcb8001c5e6d8332af945f2706033a0a983f72d1e9d402715e492fd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9429906"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7600105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1027330021479"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026556366"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1027330021479", 
      "https://app.dimensions.ai/details/publication/pub.1026556366"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000505.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FA%3A1027330021479"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1027330021479'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1027330021479'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1027330021479'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1027330021479'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      84 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1027330021479 schema:about N198ae5bdd2714059b8f72a0142253e04
2 N3135610e41c34d588e2c756c7b290f41
3 N31360f23f17842db8e7fdd12d1b5b4d1
4 N49e0123eb8144baba615f61c261caf1c
5 N5f3a3f20e8fa4a36a017bc28e2351846
6 N6ab7f139c85c4710a2a42241fe6de771
7 N7d464cbf6e2c4a65b806c3ba55dc243e
8 N9f086c31267d46119bfee2a004400cfa
9 Nb6978f1f5b774c02a9e64b7ef90b54ae
10 Nc09b2f3c918a4084a2087b3270bd3be9
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N4c35d456a9174b9285636a5cbc4f3f73
14 schema:citation sg:pub.10.1007/bf01966446
15 sg:pub.10.1007/bf01986574
16 sg:pub.10.1038/375408a0
17 sg:pub.10.1038/icb.1994.60
18 sg:pub.10.1038/nm1196-1259
19 https://app.dimensions.ai/details/publication/pub.1078374052
20 https://app.dimensions.ai/details/publication/pub.1079473236
21 https://app.dimensions.ai/details/publication/pub.1079555170
22 https://app.dimensions.ai/details/publication/pub.1082430734
23 https://app.dimensions.ai/details/publication/pub.1082467480
24 https://app.dimensions.ai/details/publication/pub.1082800784
25 https://app.dimensions.ai/details/publication/pub.1083144933
26 https://doi.org/10.1002/art.1780370209
27 https://doi.org/10.1002/art.1780370601
28 https://doi.org/10.1002/art.1780390207
29 https://doi.org/10.1002/art.1780390208
30 https://doi.org/10.1002/art.1780400104
31 https://doi.org/10.1002/cyto.990130512
32 https://doi.org/10.1006/clin.1995.1115
33 https://doi.org/10.1016/0006-2952(94)90402-2
34 https://doi.org/10.1016/0006-2952(95)00238-u
35 https://doi.org/10.1016/0014-2999(95)00145-b
36 https://doi.org/10.1016/0014-5793(90)80564-y
37 https://doi.org/10.1016/0014-5793(91)81293-h
38 https://doi.org/10.1016/0014-5793(94)80566-0
39 https://doi.org/10.1016/0022-1759(90)90198-5
40 https://doi.org/10.1016/0140-6736(90)91445-g
41 https://doi.org/10.1056/nejm199505183322008
42 https://doi.org/10.1073/pnas.86.7.2374
43 https://doi.org/10.1073/pnas.91.1.271
44 https://doi.org/10.1073/pnas.92.8.3473
45 https://doi.org/10.1093/rheumatology/32.9.816
46 https://doi.org/10.1111/j.1365-2249.1997.263-ce1154.x
47 https://doi.org/10.1111/j.1476-5381.1995.tb15916.x
48 https://doi.org/10.1136/ard.54.10.820
49 https://doi.org/10.1136/ard.54.10.841
50 https://doi.org/10.1146/annurev.bb.23.060194.001205
51 https://doi.org/10.1159/000126651
52 https://doi.org/10.1172/jci113301
53 https://doi.org/10.1172/jci114101
54 https://doi.org/10.1172/jci116791
55 https://doi.org/10.1172/jci117060
56 https://doi.org/10.1172/jci118292
57 https://doi.org/10.1210/endo.136.7.7789338
58 https://doi.org/10.1677/jme.0.0090273
59 schema:datePublished 1997-12
60 schema:datePublishedReg 1997-12-01
61 schema:description The glucocorticoid-induced antiinflammatory protein lipocortin 1 is present in arthritic synovium but its ability to regulate joint inflammation has not previously been studied. We investigated the role of lipocortin 1 in the antiinflammatory activity of glucocorticoids in an acute arthritis model induced by intraarticular injection of carrageenan. Compared to control joints (0.09 +/- 0.08 x 10(6) synovial fluid cell count), carrageenan injected joints exhibited marked infiltration of PMN (10.2 +/- 0.7 x 10(6), p < 0.001). Both intraperitoneal (1.0 mg/kg) and intraarticular administration (5 micrograms) of dexamethasone (DEX) significantly suppressed arthritis severity (p < 0.001 and 0.005, respectively), and the effects of DEX were significantly prevented by intra-articular injection of antilipocortin 1 mAb (p < 0.05). Carrageenan arthritis was also significantly inhibited by intraarticular administration of the N-terminal lipocortin 1 peptide Ac2-26 at doses of 1 or 2 mg/kg (p < 0.01). Intraarticular injection antilipocortin 1 mAb in the absence of DEX also significantly exacerbated arthritis severity (p < 0.005). In vitro treatment of PMN with DEX was associated with significant inhibition of phagocytosis (p < 0.005) and reactive oxygen species (ROS) generation (p < 0.001). Antilipocortin 1 mAb significantly reduced the inhibitory effects of DEX (p < 0.01 and 0.005, respectively). These results demonstrate that lipocortin 1 mediates the effects of exogenous glucocorticoids on neutrophil migration in carrageenan-induced acute arthritis, exerts an endogenous antiinflammatory influence, and mediates glucocorticoid inhibition of neutrophil activation.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N3899fe79324d44bf898fb00c5ff07333
66 N9f383e1f3f494092bd7b47e3737492ff
67 sg:journal.1084792
68 schema:name Antiinflammatory Effect of Lipocortin 1 in Experimental Arthritis
69 schema:pagination 583-596
70 schema:productId N3944430dd5db46fd9585a6e6099fc9e0
71 N70be02e354e343638f416c42049446a6
72 N91003630a81948ab835ef545932387a2
73 Ne42c19fe9a6445ebac80e1dc0505f797
74 Nfafa2a5757c041b3b894cdab2b6cb182
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026556366
76 https://doi.org/10.1023/a:1027330021479
77 schema:sdDatePublished 2019-04-10T21:35
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N17df6f05a1e643e1a61a51e0c2286706
80 schema:url http://link.springer.com/10.1023%2FA%3A1027330021479
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N17227c117f95495eb030663601925d68 rdf:first sg:person.01131260677.45
85 rdf:rest N52ab0b8c5af24434a7cbbbc044ac39e0
86 N17df6f05a1e643e1a61a51e0c2286706 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N198ae5bdd2714059b8f72a0142253e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Excipients
90 rdf:type schema:DefinedTerm
91 N3135610e41c34d588e2c756c7b290f41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Rats, Sprague-Dawley
93 rdf:type schema:DefinedTerm
94 N31360f23f17842db8e7fdd12d1b5b4d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Disease Models, Animal
96 rdf:type schema:DefinedTerm
97 N3899fe79324d44bf898fb00c5ff07333 schema:issueNumber 6
98 rdf:type schema:PublicationIssue
99 N3944430dd5db46fd9585a6e6099fc9e0 schema:name nlm_unique_id
100 schema:value 7600105
101 rdf:type schema:PropertyValue
102 N49e0123eb8144baba615f61c261caf1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N4c35d456a9174b9285636a5cbc4f3f73 rdf:first sg:person.0716605557.36
106 rdf:rest N985f63457f4a4fd589362a6880415f7b
107 N52ab0b8c5af24434a7cbbbc044ac39e0 rdf:first sg:person.01136315644.52
108 rdf:rest rdf:nil
109 N5f3a3f20e8fa4a36a017bc28e2351846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Carrageenan
111 rdf:type schema:DefinedTerm
112 N6ab7f139c85c4710a2a42241fe6de771 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Annexin A1
114 rdf:type schema:DefinedTerm
115 N70be02e354e343638f416c42049446a6 schema:name readcube_id
116 schema:value 7e83d3560fcb8001c5e6d8332af945f2706033a0a983f72d1e9d402715e492fd
117 rdf:type schema:PropertyValue
118 N7d464cbf6e2c4a65b806c3ba55dc243e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Arthritis
120 rdf:type schema:DefinedTerm
121 N7f0ab5f1812f4e94956fbfa4307e2fb1 rdf:first sg:person.01154000650.14
122 rdf:rest N17227c117f95495eb030663601925d68
123 N91003630a81948ab835ef545932387a2 schema:name dimensions_id
124 schema:value pub.1026556366
125 rdf:type schema:PropertyValue
126 N985f63457f4a4fd589362a6880415f7b rdf:first sg:person.01303310332.07
127 rdf:rest N7f0ab5f1812f4e94956fbfa4307e2fb1
128 N9f086c31267d46119bfee2a004400cfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Inflammation
130 rdf:type schema:DefinedTerm
131 N9f383e1f3f494092bd7b47e3737492ff schema:volumeNumber 21
132 rdf:type schema:PublicationVolume
133 Nb6978f1f5b774c02a9e64b7ef90b54ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Male
135 rdf:type schema:DefinedTerm
136 Nc09b2f3c918a4084a2087b3270bd3be9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Rats
138 rdf:type schema:DefinedTerm
139 Ne42c19fe9a6445ebac80e1dc0505f797 schema:name doi
140 schema:value 10.1023/a:1027330021479
141 rdf:type schema:PropertyValue
142 Nfafa2a5757c041b3b894cdab2b6cb182 schema:name pubmed_id
143 schema:value 9429906
144 rdf:type schema:PropertyValue
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:journal.1084792 schema:issn 0360-3997
152 1573-2576
153 schema:name Inflammation
154 rdf:type schema:Periodical
155 sg:person.01131260677.45 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
156 schema:familyName Holdsworth
157 schema:givenName Stephen R.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
159 rdf:type schema:Person
160 sg:person.01136315644.52 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
161 schema:familyName Morand
162 schema:givenName Eric F.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136315644.52
164 rdf:type schema:Person
165 sg:person.01154000650.14 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
166 schema:familyName Hutchinson
167 schema:givenName Paul
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154000650.14
169 rdf:type schema:Person
170 sg:person.01303310332.07 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
171 schema:familyName Leech
172 schema:givenName Michelle
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303310332.07
174 rdf:type schema:Person
175 sg:person.0716605557.36 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
176 schema:familyName Yang
177 schema:givenName Yuanhang
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716605557.36
179 rdf:type schema:Person
180 sg:pub.10.1007/bf01966446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012083413
181 https://doi.org/10.1007/bf01966446
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/bf01986574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031173250
184 https://doi.org/10.1007/bf01986574
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/375408a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024106872
187 https://doi.org/10.1038/375408a0
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/icb.1994.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048016147
190 https://doi.org/10.1038/icb.1994.60
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nm1196-1259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041509450
193 https://doi.org/10.1038/nm1196-1259
194 rdf:type schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1078374052 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1079473236 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1079555170 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1082430734 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1082467480 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1082800784 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1083144933 schema:CreativeWork
202 https://doi.org/10.1002/art.1780370209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042008167
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/art.1780370601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029990974
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/art.1780390207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014478257
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/art.1780390208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021094164
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/art.1780400104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022147597
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/cyto.990130512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031411127
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1006/clin.1995.1115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007263272
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/0006-2952(94)90402-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003273897
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0006-2952(95)00238-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1022987978
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0014-2999(95)00145-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1023088562
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0014-5793(90)80564-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1003279078
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0014-5793(91)81293-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1023257964
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0014-5793(94)80566-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026435238
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0022-1759(90)90198-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005518355
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0140-6736(90)91445-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1023700514
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1056/nejm199505183322008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031448544
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1073/pnas.86.7.2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984190
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.91.1.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026326615
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.92.8.3473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009107163
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/rheumatology/32.9.816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060010559
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1365-2249.1997.263-ce1154.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012712183
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1476-5381.1995.tb15916.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042993907
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/ard.54.10.820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052146162
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1136/ard.54.10.841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024772495
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1146/annurev.bb.23.060194.001205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021371271
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1159/000126651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003152568
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1172/jci113301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040034773
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1172/jci114101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045985173
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1172/jci116791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045727912
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1172/jci117060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027343186
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1172/jci118292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017718368
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1210/endo.136.7.7789338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064280288
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1677/jme.0.0090273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005484213
267 rdf:type schema:CreativeWork
268 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
269 schema:name Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...