Remodeling of Vascular Wall in Crohn's Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Yuji Funayama, Iwao Sasaki, Hiroo Naito, Kohei Fukushima, Seiki Matsuno, Takayuki Masuda

ABSTRACT

To clarify the changes in vascular resistance inCrohn's disease, we studied changes in the thickness ofarterial media histometrically. The resected specimensof mesenterium and intestine from 18 patients with Crohn's disease were used. Each intestinallesion was classified into three grades: noinflammation, exudative change, and fibrosing change. Inthe ileum, significant atrophy in the media of thesubmucosal peripheral arteries was noted during exudativeand fibrosing changes, while in the submucosal largervessels or in the mesenterium, the thickness of thearterial media did not change. In the colon, atrophy in the media of the submucosal arteries wasnoted in all stages except in the larger vessel duringexudative change, while no significant changes werenoted in the mesenterium. In conclusion, it is suggested that circulatory disturbance occurs even in theearly stage in Crohn's disease, and there seems to beincreased vascular resistance in the area between thedeep submucosal and the distal mesentericarteries. More... »

PAGES

2319-2323

References to SciGraph publications

  • 1991-08. Smoking, the oral contraceptive pill, and Crohn's disease in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1026677325411

    DOI

    http://dx.doi.org/10.1023/a:1026677325411

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018967176

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10573381


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