Ontology type: schema:ScholarlyArticle
1999-06
AUTHORSChikashi Shibata, Iwao Sasaki, Hiroo Naito, Tatsuya Ueno, Seiki Matsuno
ABSTRACTThe aim of the present study was to investigatethe effect and mechanism of action of intragastric andintraduodenal capsaicin on gastrointestinal motility.Five mongrel dogs were equipped with eight strain gauge force transducers on the stomach, smallintestine, and proximal colon. In the interdigestivestate, capsaicin was administered into the gastric orduodenal lumen. The effects of atropine, hexamethonium, ondansetron, and FK888 on capsaicin-inducedcontractions were studied. Intragastric capsaicininduced contractions within 15 min in the gastricantrum, duodenum, proximal jejunum, and proximal colon.These stimulatory effects were inhibited by atropineat all sites; by hexamethonium in the small intestineand colon; by ondansetron in the antrum, duodenum, andcolon; and by FK888 in the antrum and colon,respectively. Intraduodenal capsaicin had no effect oncontractility. Stimulation of afferent fibers bycapsaicin in the stomach but not in the duodenumaugments contractile activity in local and distantregions of the gut via distinct pathways. More... »
PAGES1083-1089
http://scigraph.springernature.com/pub.10.1023/a:1026651518373
DOIhttp://dx.doi.org/10.1023/a:1026651518373
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10389677
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