Anti-Cardiolipin Antibodies in Patients with Inflammatory Bowel Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

Berendt W. Aichbichler, Wolfgang Petritsch, Gerhard A. Reicht, Heimo H. Wenzl, Andreas J. Eherer, Thomas A. Hinterleitner, Piet Auer-Grumbach, Guenter J. Krejs

ABSTRACT

Elevated levels of anti-cardiolipin antibodiesare associated with an increased risk for venous andarterial thrombosis. In patients with inflammatory boweldisease thrombosis is a well known complication. We determined the prevalence of elevatedanti-cardiolipin antibodies in 136 patients withinflammatory bowel disease compared with 136 healthycontrols and analyzed thromboembolic complications inpatients with increased anti-cardiolipin antibodylevels. Anti-cardiolipin antibody titers weresignificantly elevated in patients with Crohn's disease(5.7 units/ml) and ulcerative colitis (5.3 units/ml)compared to the control group (2.5 units/ml). We foundno correlation between disease activity andanti-cardiolipin antibody levels. Seven patients haddeep venous thrombosis in their history, in three ofthem this was complicated by pulmonary embolism. In onlytwo of the seven patients with deep venous thrombosiswere anti-cardiolipin antibody levels increased. Inconclusion, anti-cardiolipin antibody titers were significantly increased in patients withinflammatory bowel disease. Elevated anti-cardiolipinantibody levels appear to play no role in thepathogenesis of thromboembolic events in patients withinflammatory bowel disease. More... »

PAGES

852-856

References to SciGraph publications

  • 1994-07. Prevalence and significance of anticardiolipin antibodies in Crohn's disease in DIGESTIVE DISEASES AND SCIENCES
  • 1991-08. Smoking, the oral contraceptive pill, and Crohn's disease in DIGESTIVE DISEASES AND SCIENCES
  • 1992-06. Risk of thromboembolic complications in patients with inflammatory bowel disease in INTERNATIONAL JOURNAL OF CLINICAL AND LABORATORY RESEARCH
  • 1993-03. Anti-endothelial cell antibodies in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • 1978-10. Hemostatic alterations in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • 1978-12. Arterial thrombosis in ulcerative colitis in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1026646816672

    DOI

    http://dx.doi.org/10.1023/a:1026646816672

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051896972

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10219848


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