On the Evolution of Primitive Genetic Codes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10

AUTHORS

Günter Weberndorfer, Ivo L. Hofacker, Peter F. Stadler

ABSTRACT

The primordial genetic code probably has been a drastically simplified ancestor of the canonical code that is used by contemporary cells. In order to understand how the present-day code came about we first need to explain how the language of the building plan can change without destroying the encoded information. In this work we introduce a minimal organism model that is based on biophysically reasonable descriptions of RNA and protein, namely secondary structure folding and knowledge based potentials. The evolution of a population of such organism under competition for a common resource is simulated explicitly at the level of individual replication events. Starting with very simple codes, and hence greatly reduced amino acid alphabets, we observe a diversification of the codes in most simulation runs. The driving force behind this effect is the possibility to produce fitter proteins when the repertoire of amino acids is enlarged. More... »

PAGES

491-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1025753712110

DOI

http://dx.doi.org/10.1023/a:1025753712110

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030969692

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14604188


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