Radioimmunoscintigraphy of Intracranial Glioma Xenograft with a Technetium-99m-Labeled Mouse Monoclonal Antibody Specifically Recognizing Type III Mutant Epidermal Growth Factor Receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07

AUTHORS

Syuntaro Takasu, Toshitada Takahashi, Sho Okamoto, Noboru Oriuchi, Norihisa Nakayashiki, Kenta Okamoto, Hideki Muramatsu, Takeshi Hayashi, Norimoto Nakahara, Masaaki Mizuno, Toshihiko Wakabayashi, Tetsuya Higuchi, Keigo Endo, Kenichi Kozaki, Osamu Miyaishi, Shinsuke Saga, Ryuzo Ueda, Jun Yoshida, Kazuhiro Yoshikawa

ABSTRACT

The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mice bearing the intracranial glioma xenograft overexpressing the EGFRvIII. Human glioma cell line, U87MG, expressing the wild type EGFR and the transfectant, named U87MG x deltaEGFR, expressing the EGFRvIII, were transplanted subcutaneously or intracranially to nude mice. 3C10 mAb labeled with a technetium-99m (99mTc) was intravenously injected into these nude mice and then the mice were sacrificed at 24 h later, and the 99mTc-uptake by xenografts and major normal organs was measured to determine the biodistribution of mAb. Furthermore, at 3, 6 and 24 h after injection of 99mTc-labeled 3C10 mAb, whole-body scintigraphy was obtained with a gamma camera to localize the tumor site. 3C10 mAb significantly accumulated to U87MG x deltaEGFR xenografts transplanted subcutaneously or intracranially in nude mice, showing high tumor-to-blood ratio of 10.30 and 4.01, respectively. In contrast, uptake of control antibody in the intracranial tumor was as low as 0.43. In scintigrams, intracranially transplanted U87MG x deltaEGFR xenografts were detectable at 3 h after injection of 99mTc-labeled 3C10 mAb. These results suggest that intravenously injected 3C10 mAb specifically accumulated to the subcutaneous or intracranial glioma xenograft expressing the EGFRvIII and 3C10 mAb is a potential diagnostic and therapeutic agent for patients with gliomas expressing the EGFRvIII. More... »

PAGES

247-256

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1024320516341

DOI

http://dx.doi.org/10.1023/a:1024320516341

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049970223

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12892230


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoconjugates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Subcutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioimmunodetection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radionuclide Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Technetium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takasu", 
        "givenName": "Syuntaro", 
        "id": "sg:person.01246465006.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246465006.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Aichi-Cancer Center Research Institute, Chikusa-ku, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Toshitada", 
        "id": "sg:person.015206120374.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206120374.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamoto", 
        "givenName": "Sho", 
        "id": "sg:person.0600245115.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600245115.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gunma University", 
          "id": "https://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Department of Nuclear Medicine & Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oriuchi", 
        "givenName": "Noboru", 
        "id": "sg:person.01170307223.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170307223.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakayashiki", 
        "givenName": "Norihisa", 
        "id": "sg:person.01240715341.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240715341.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamoto", 
        "givenName": "Kenta", 
        "id": "sg:person.0677653041.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677653041.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Hideki", 
        "id": "sg:person.011165166412.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011165166412.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Takeshi", 
        "id": "sg:person.01067764306.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067764306.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakahara", 
        "givenName": "Norimoto", 
        "id": "sg:person.0607502175.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607502175.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuno", 
        "givenName": "Masaaki", 
        "id": "sg:person.01025445774.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025445774.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakabayashi", 
        "givenName": "Toshihiko", 
        "id": "sg:person.01367256160.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367256160.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gunma University", 
          "id": "https://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Department of Nuclear Medicine & Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higuchi", 
        "givenName": "Tetsuya", 
        "id": "sg:person.0607076675.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607076675.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gunma University", 
          "id": "https://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Department of Nuclear Medicine & Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Endo", 
        "givenName": "Keigo", 
        "id": "sg:person.01052507731.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052507731.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kozaki", 
        "givenName": "Kenichi", 
        "id": "sg:person.01072243305.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072243305.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyaishi", 
        "givenName": "Osamu", 
        "id": "sg:person.01045426467.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045426467.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saga", 
        "givenName": "Shinsuke", 
        "id": "sg:person.01023357016.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023357016.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya City University", 
          "id": "https://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Ryuzo", 
        "id": "sg:person.01067610467.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067610467.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Jun", 
        "id": "sg:person.0672510657.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672510657.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gunma University", 
          "id": "https://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Department of Nuclear Medicine & Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikawa", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.0766017060.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766017060.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006551667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.10.5724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011582330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005812417638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011786304", 
          "https://doi.org/10.1023/a:1005812417638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910630414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013451734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018591552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021564499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(95)00052-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022833904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1159/000059704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025134863", 
          "https://doi.org/10.1159/000059704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2000.tb00882.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028271017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2000.tb00882.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028271017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930230318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029918918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1990.tb02644.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035410859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1990.tb02644.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035410859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039536813", 
          "https://doi.org/10.1038/bjc.1996.260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039536813", 
          "https://doi.org/10.1038/bjc.1996.260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.11.824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040387888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.52.8.574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046117028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006354102377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047037905", 
          "https://doi.org/10.1023/a:1006354102377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.16.7727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047086945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02482738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047802274", 
          "https://doi.org/10.1007/bf02482738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02482738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047802274", 
          "https://doi.org/10.1007/bf02482738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.21.8602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049713289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.11.4207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050712408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.1999.0898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319323", 
          "https://doi.org/10.1054/bjoc.1999.0898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-199912000-00034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060250470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.5.1389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3109/13550289809114515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070986052", 
          "https://doi.org/10.3109/13550289809114515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074834931", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074849706", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074849707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077941527", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078691359", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078722004", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079548094", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079645663", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082419181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424647", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082432622", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082787471", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083151277", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-07", 
    "datePublishedReg": "2003-07-01", 
    "description": "The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mice bearing the intracranial glioma xenograft overexpressing the EGFRvIII. Human glioma cell line, U87MG, expressing the wild type EGFR and the transfectant, named U87MG x deltaEGFR, expressing the EGFRvIII, were transplanted subcutaneously or intracranially to nude mice. 3C10 mAb labeled with a technetium-99m (99mTc) was intravenously injected into these nude mice and then the mice were sacrificed at 24 h later, and the 99mTc-uptake by xenografts and major normal organs was measured to determine the biodistribution of mAb. Furthermore, at 3, 6 and 24 h after injection of 99mTc-labeled 3C10 mAb, whole-body scintigraphy was obtained with a gamma camera to localize the tumor site. 3C10 mAb significantly accumulated to U87MG x deltaEGFR xenografts transplanted subcutaneously or intracranially in nude mice, showing high tumor-to-blood ratio of 10.30 and 4.01, respectively. In contrast, uptake of control antibody in the intracranial tumor was as low as 0.43. In scintigrams, intracranially transplanted U87MG x deltaEGFR xenografts were detectable at 3 h after injection of 99mTc-labeled 3C10 mAb. These results suggest that intravenously injected 3C10 mAb specifically accumulated to the subcutaneous or intracranial glioma xenograft expressing the EGFRvIII and 3C10 mAb is a potential diagnostic and therapeutic agent for patients with gliomas expressing the EGFRvIII.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1024320516341", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Radioimmunoscintigraphy of Intracranial Glioma Xenograft with a Technetium-99m-Labeled Mouse Monoclonal Antibody Specifically Recognizing Type III Mutant Epidermal Growth Factor Receptor", 
    "pagination": "247-256", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ee0ac51cf54053214c97fbad15ff9724b795e63c1ebec4e49e4488f41649355e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12892230"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309335"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1024320516341"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049970223"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1024320516341", 
      "https://app.dimensions.ai/details/publication/pub.1049970223"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000537.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FA%3A1024320516341"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1024320516341'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1024320516341'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1024320516341'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1024320516341'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      83 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1024320516341 schema:about N163e4ebdf609410b8005f547fc467a06
2 N17104fa77ac84345a109ab24cdde5e45
3 N190d2e6ba63940e79c7d116fa2304960
4 N1b2efa445c064b27bdd9f89cbec1504c
5 N2a74c89493594cbb9f8e13a931e851ad
6 N2b54dec319934ce0945f241db9d128aa
7 N33bf26853a6248dca71348e4908faa2e
8 N394e98d10b194b9f8a36804b130b9d46
9 N3d1c088dcaa84674bfa804066f9e9a3e
10 N5615a16ade61447a9a516c35c3bd7851
11 N66a053f30498411c9f9cb85a0a4ef729
12 N88bc7252d11e4518870595fe93533a75
13 N9c263fec51fe4b279c3149b902fac67b
14 Nadbbe2dd526e4e9cb6b37853dd65d9c4
15 Nba92d96a98d14736baf0b7bdb26f5ba4
16 Nc8cfa5d7c59c4d42897df65e46d06de2
17 Nd1fab97314d143beb8b551960f6c98ca
18 Nff64bf4f41ae4238aa9351d9969cf8b1
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author Nb6d53421a7f7464b9e9d284c13b95cd4
22 schema:citation sg:pub.10.1007/bf02482738
23 sg:pub.10.1023/a:1005812417638
24 sg:pub.10.1023/a:1006354102377
25 sg:pub.10.1038/bjc.1996.260
26 sg:pub.10.1054/bjoc.1999.0898
27 sg:pub.10.1159/000059704
28 sg:pub.10.3109/13550289809114515
29 https://app.dimensions.ai/details/publication/pub.1074834931
30 https://app.dimensions.ai/details/publication/pub.1074849706
31 https://app.dimensions.ai/details/publication/pub.1074849707
32 https://app.dimensions.ai/details/publication/pub.1077941527
33 https://app.dimensions.ai/details/publication/pub.1078691359
34 https://app.dimensions.ai/details/publication/pub.1078722004
35 https://app.dimensions.ai/details/publication/pub.1079548094
36 https://app.dimensions.ai/details/publication/pub.1079645663
37 https://app.dimensions.ai/details/publication/pub.1082419181
38 https://app.dimensions.ai/details/publication/pub.1082424647
39 https://app.dimensions.ai/details/publication/pub.1082432622
40 https://app.dimensions.ai/details/publication/pub.1082787471
41 https://app.dimensions.ai/details/publication/pub.1083151277
42 https://doi.org/10.1002/ijc.10189
43 https://doi.org/10.1002/ijc.10224
44 https://doi.org/10.1002/ijc.2910630414
45 https://doi.org/10.1002/jso.2930230318
46 https://doi.org/10.1016/0161-5890(95)00052-g
47 https://doi.org/10.1073/pnas.87.11.4207
48 https://doi.org/10.1073/pnas.87.21.8602
49 https://doi.org/10.1073/pnas.89.7.2965
50 https://doi.org/10.1073/pnas.91.16.7727
51 https://doi.org/10.1073/pnas.95.10.5724
52 https://doi.org/10.1093/jnci/90.11.824
53 https://doi.org/10.1097/00006123-199912000-00034
54 https://doi.org/10.1111/j.1349-7006.1990.tb02644.x
55 https://doi.org/10.1111/j.1349-7006.2000.tb00882.x
56 https://doi.org/10.1136/jcp.52.8.574
57 https://doi.org/10.1200/jco.20.5.1389
58 schema:datePublished 2003-07
59 schema:datePublishedReg 2003-07-01
60 schema:description The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII), using athymic nude mice bearing the intracranial glioma xenograft overexpressing the EGFRvIII. Human glioma cell line, U87MG, expressing the wild type EGFR and the transfectant, named U87MG x deltaEGFR, expressing the EGFRvIII, were transplanted subcutaneously or intracranially to nude mice. 3C10 mAb labeled with a technetium-99m (99mTc) was intravenously injected into these nude mice and then the mice were sacrificed at 24 h later, and the 99mTc-uptake by xenografts and major normal organs was measured to determine the biodistribution of mAb. Furthermore, at 3, 6 and 24 h after injection of 99mTc-labeled 3C10 mAb, whole-body scintigraphy was obtained with a gamma camera to localize the tumor site. 3C10 mAb significantly accumulated to U87MG x deltaEGFR xenografts transplanted subcutaneously or intracranially in nude mice, showing high tumor-to-blood ratio of 10.30 and 4.01, respectively. In contrast, uptake of control antibody in the intracranial tumor was as low as 0.43. In scintigrams, intracranially transplanted U87MG x deltaEGFR xenografts were detectable at 3 h after injection of 99mTc-labeled 3C10 mAb. These results suggest that intravenously injected 3C10 mAb specifically accumulated to the subcutaneous or intracranial glioma xenograft expressing the EGFRvIII and 3C10 mAb is a potential diagnostic and therapeutic agent for patients with gliomas expressing the EGFRvIII.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf Nbe2c8aa22326414d913644ead8726f82
65 Ncb6a619671e5489c9a93989d36665b8b
66 sg:journal.1094205
67 schema:name Radioimmunoscintigraphy of Intracranial Glioma Xenograft with a Technetium-99m-Labeled Mouse Monoclonal Antibody Specifically Recognizing Type III Mutant Epidermal Growth Factor Receptor
68 schema:pagination 247-256
69 schema:productId N10028e7464464dd08e28a99cb084cc2b
70 N33a9e2fe5efe4cf58fd85b163455890f
71 N5bcb61f61d8f4670acda2201cd3a052c
72 N5eb8c69ad62f4321bae0d46758b93a92
73 Nef4b5f2b663242748fe5ee1adbe5faa8
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049970223
75 https://doi.org/10.1023/a:1024320516341
76 schema:sdDatePublished 2019-04-10T15:06
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nf7d21055ffef4994a119ed86961b743f
79 schema:url http://link.springer.com/10.1023%2FA%3A1024320516341
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N10028e7464464dd08e28a99cb084cc2b schema:name dimensions_id
84 schema:value pub.1049970223
85 rdf:type schema:PropertyValue
86 N163e4ebdf609410b8005f547fc467a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 N17104fa77ac84345a109ab24cdde5e45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mutation
91 rdf:type schema:DefinedTerm
92 N190d2e6ba63940e79c7d116fa2304960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Mice
94 rdf:type schema:DefinedTerm
95 N1b10870dce5e4907af91324b47eef581 rdf:first sg:person.0677653041.24
96 rdf:rest Nfdbb882a2d76445e9bbc806596b6650d
97 N1b2efa445c064b27bdd9f89cbec1504c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Technetium
99 rdf:type schema:DefinedTerm
100 N1f76dd8252de4a05a78069e69a6114d7 rdf:first sg:person.01052507731.15
101 rdf:rest Nf3e3dbff22344a0e9d95c5add9420464
102 N2a74c89493594cbb9f8e13a931e851ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Radioimmunodetection
104 rdf:type schema:DefinedTerm
105 N2b54dec319934ce0945f241db9d128aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N302a58a5dadc45e4b013b8dc1a909911 rdf:first sg:person.0607502175.88
109 rdf:rest N3283e7bedf2a4d808fda04deab31277e
110 N3283e7bedf2a4d808fda04deab31277e rdf:first sg:person.01025445774.82
111 rdf:rest N74c55ebfd3f3487a957a9a03be457db3
112 N33a9e2fe5efe4cf58fd85b163455890f schema:name readcube_id
113 schema:value ee0ac51cf54053214c97fbad15ff9724b795e63c1ebec4e49e4488f41649355e
114 rdf:type schema:PropertyValue
115 N33bf26853a6248dca71348e4908faa2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Tumor Cells, Cultured
117 rdf:type schema:DefinedTerm
118 N394e98d10b194b9f8a36804b130b9d46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice, Nude
120 rdf:type schema:DefinedTerm
121 N3d1c088dcaa84674bfa804066f9e9a3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Transplantation, Heterologous
123 rdf:type schema:DefinedTerm
124 N4a557479571d48cc855b41922e5bb913 rdf:first sg:person.01067764306.86
125 rdf:rest N302a58a5dadc45e4b013b8dc1a909911
126 N5451de0cbff34957afb54f7716d2dd29 rdf:first sg:person.01170307223.39
127 rdf:rest N7f754912531c46f59ac0ccdb5f7e7243
128 N5615a16ade61447a9a516c35c3bd7851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Injections, Subcutaneous
130 rdf:type schema:DefinedTerm
131 N5bcb61f61d8f4670acda2201cd3a052c schema:name pubmed_id
132 schema:value 12892230
133 rdf:type schema:PropertyValue
134 N5eb8c69ad62f4321bae0d46758b93a92 schema:name nlm_unique_id
135 schema:value 8309335
136 rdf:type schema:PropertyValue
137 N66a053f30498411c9f9cb85a0a4ef729 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Immunoconjugates
139 rdf:type schema:DefinedTerm
140 N733ec3a02c734b588bea82d79fc95358 rdf:first sg:person.0766017060.02
141 rdf:rest rdf:nil
142 N74c55ebfd3f3487a957a9a03be457db3 rdf:first sg:person.01367256160.54
143 rdf:rest N8f4cc6ca450f49fdb0a8ea0bd9df705f
144 N7862381be2dd43b791a5104cd752bea6 rdf:first sg:person.0672510657.24
145 rdf:rest N733ec3a02c734b588bea82d79fc95358
146 N7f754912531c46f59ac0ccdb5f7e7243 rdf:first sg:person.01240715341.62
147 rdf:rest N1b10870dce5e4907af91324b47eef581
148 N80970debd08e4130bdda46211c4a8ceb rdf:first sg:person.01067610467.20
149 rdf:rest N7862381be2dd43b791a5104cd752bea6
150 N81d48eabffb249ea99c541d044177f62 rdf:first sg:person.01045426467.22
151 rdf:rest N8c93d4201e7e459798d27b9cf69fdc86
152 N8724ad86e23a4dbf8b6fc0f48b252399 schema:name Aichi-Cancer Center Research Institute, Chikusa-ku, Japan
153 rdf:type schema:Organization
154 N88bc7252d11e4518870595fe93533a75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Antibodies, Monoclonal
156 rdf:type schema:DefinedTerm
157 N8c93d4201e7e459798d27b9cf69fdc86 rdf:first sg:person.01023357016.70
158 rdf:rest N80970debd08e4130bdda46211c4a8ceb
159 N8d5227cba4a348a19929801098d4e806 rdf:first sg:person.015206120374.50
160 rdf:rest N8ef74450c2ec4a13940fc01f659338d7
161 N8ef74450c2ec4a13940fc01f659338d7 rdf:first sg:person.0600245115.10
162 rdf:rest N5451de0cbff34957afb54f7716d2dd29
163 N8f4cc6ca450f49fdb0a8ea0bd9df705f rdf:first sg:person.0607076675.56
164 rdf:rest N1f76dd8252de4a05a78069e69a6114d7
165 N9c263fec51fe4b279c3149b902fac67b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 Nadbbe2dd526e4e9cb6b37853dd65d9c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Brain Neoplasms
170 rdf:type schema:DefinedTerm
171 Nb6d53421a7f7464b9e9d284c13b95cd4 rdf:first sg:person.01246465006.09
172 rdf:rest N8d5227cba4a348a19929801098d4e806
173 Nba92d96a98d14736baf0b7bdb26f5ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Glioma
175 rdf:type schema:DefinedTerm
176 Nbe2c8aa22326414d913644ead8726f82 schema:issueNumber 3
177 rdf:type schema:PublicationIssue
178 Nc8cfa5d7c59c4d42897df65e46d06de2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Receptor, Epidermal Growth Factor
180 rdf:type schema:DefinedTerm
181 Ncb6a619671e5489c9a93989d36665b8b schema:volumeNumber 63
182 rdf:type schema:PublicationVolume
183 Nd1fab97314d143beb8b551960f6c98ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Mice, Inbred BALB C
185 rdf:type schema:DefinedTerm
186 Nef4b5f2b663242748fe5ee1adbe5faa8 schema:name doi
187 schema:value 10.1023/a:1024320516341
188 rdf:type schema:PropertyValue
189 Nf3e3dbff22344a0e9d95c5add9420464 rdf:first sg:person.01072243305.17
190 rdf:rest N81d48eabffb249ea99c541d044177f62
191 Nf7d21055ffef4994a119ed86961b743f schema:name Springer Nature - SN SciGraph project
192 rdf:type schema:Organization
193 Nfdbb882a2d76445e9bbc806596b6650d rdf:first sg:person.011165166412.89
194 rdf:rest N4a557479571d48cc855b41922e5bb913
195 Nff64bf4f41ae4238aa9351d9969cf8b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Radionuclide Imaging
197 rdf:type schema:DefinedTerm
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
202 schema:name Immunology
203 rdf:type schema:DefinedTerm
204 sg:journal.1094205 schema:issn 0167-594X
205 1573-7373
206 schema:name Journal of Neuro-Oncology
207 rdf:type schema:Periodical
208 sg:person.01023357016.70 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
209 schema:familyName Saga
210 schema:givenName Shinsuke
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023357016.70
212 rdf:type schema:Person
213 sg:person.01025445774.82 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
214 schema:familyName Mizuno
215 schema:givenName Masaaki
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025445774.82
217 rdf:type schema:Person
218 sg:person.01045426467.22 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
219 schema:familyName Miyaishi
220 schema:givenName Osamu
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045426467.22
222 rdf:type schema:Person
223 sg:person.01052507731.15 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
224 schema:familyName Endo
225 schema:givenName Keigo
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052507731.15
227 rdf:type schema:Person
228 sg:person.01067610467.20 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
229 schema:familyName Ueda
230 schema:givenName Ryuzo
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067610467.20
232 rdf:type schema:Person
233 sg:person.01067764306.86 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
234 schema:familyName Hayashi
235 schema:givenName Takeshi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067764306.86
237 rdf:type schema:Person
238 sg:person.01072243305.17 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
239 schema:familyName Kozaki
240 schema:givenName Kenichi
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072243305.17
242 rdf:type schema:Person
243 sg:person.011165166412.89 schema:affiliation https://www.grid.ac/institutes/grid.260433.0
244 schema:familyName Muramatsu
245 schema:givenName Hideki
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011165166412.89
247 rdf:type schema:Person
248 sg:person.01170307223.39 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
249 schema:familyName Oriuchi
250 schema:givenName Noboru
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170307223.39
252 rdf:type schema:Person
253 sg:person.01240715341.62 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
254 schema:familyName Nakayashiki
255 schema:givenName Norihisa
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240715341.62
257 rdf:type schema:Person
258 sg:person.01246465006.09 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
259 schema:familyName Takasu
260 schema:givenName Syuntaro
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246465006.09
262 rdf:type schema:Person
263 sg:person.01367256160.54 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
264 schema:familyName Wakabayashi
265 schema:givenName Toshihiko
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367256160.54
267 rdf:type schema:Person
268 sg:person.015206120374.50 schema:affiliation N8724ad86e23a4dbf8b6fc0f48b252399
269 schema:familyName Takahashi
270 schema:givenName Toshitada
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206120374.50
272 rdf:type schema:Person
273 sg:person.0600245115.10 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
274 schema:familyName Okamoto
275 schema:givenName Sho
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600245115.10
277 rdf:type schema:Person
278 sg:person.0607076675.56 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
279 schema:familyName Higuchi
280 schema:givenName Tetsuya
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607076675.56
282 rdf:type schema:Person
283 sg:person.0607502175.88 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
284 schema:familyName Nakahara
285 schema:givenName Norimoto
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607502175.88
287 rdf:type schema:Person
288 sg:person.0672510657.24 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
289 schema:familyName Yoshida
290 schema:givenName Jun
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672510657.24
292 rdf:type schema:Person
293 sg:person.0677653041.24 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
294 schema:familyName Okamoto
295 schema:givenName Kenta
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677653041.24
297 rdf:type schema:Person
298 sg:person.0766017060.02 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
299 schema:familyName Yoshikawa
300 schema:givenName Kazuhiro
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766017060.02
302 rdf:type schema:Person
303 sg:pub.10.1007/bf02482738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047802274
304 https://doi.org/10.1007/bf02482738
305 rdf:type schema:CreativeWork
306 sg:pub.10.1023/a:1005812417638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011786304
307 https://doi.org/10.1023/a:1005812417638
308 rdf:type schema:CreativeWork
309 sg:pub.10.1023/a:1006354102377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047037905
310 https://doi.org/10.1023/a:1006354102377
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/bjc.1996.260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039536813
313 https://doi.org/10.1038/bjc.1996.260
314 rdf:type schema:CreativeWork
315 sg:pub.10.1054/bjoc.1999.0898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319323
316 https://doi.org/10.1054/bjoc.1999.0898
317 rdf:type schema:CreativeWork
318 sg:pub.10.1159/000059704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025134863
319 https://doi.org/10.1159/000059704
320 rdf:type schema:CreativeWork
321 sg:pub.10.3109/13550289809114515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070986052
322 https://doi.org/10.3109/13550289809114515
323 rdf:type schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1074834931 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1074849706 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1074849707 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1077941527 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1078691359 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1078722004 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1079548094 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1079645663 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1082419181 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1082424647 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1082432622 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1082787471 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1083151277 schema:CreativeWork
337 https://doi.org/10.1002/ijc.10189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018591552
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1002/ijc.10224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021564499
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1002/ijc.2910630414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013451734
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1002/jso.2930230318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029918918
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/0161-5890(95)00052-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1022833904
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1073/pnas.87.11.4207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050712408
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1073/pnas.87.21.8602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049713289
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.89.7.2965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006551667
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1073/pnas.91.16.7727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047086945
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1073/pnas.95.10.5724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011582330
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/jnci/90.11.824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040387888
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/00006123-199912000-00034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060250470
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1111/j.1349-7006.1990.tb02644.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035410859
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1111/j.1349-7006.2000.tb00882.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028271017
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1136/jcp.52.8.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046117028
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1200/jco.20.5.1389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202864
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.256642.1 schema:alternateName Gunma University
370 schema:name Department of Nuclear Medicine & Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Nagoya, Japan
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.260433.0 schema:alternateName Nagoya City University
373 schema:name Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-cho, Mizuho-ku, Nagoya, Japan
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
376 schema:name Department of Neurosurgery, Division of Immunology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...