Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Annekatrin Lukanova, Eva Lundin, Andrea Micheli, Arslan Akhmedkhanov, Sabina Rinaldi, Paola Muti, Per Lenner, Carine Biessy, Vittorio Krogh, Elio Riboli, Göran Hallmans, Franco Berrino, Anne Zeleniuch-Jacquotte, Paolo Toniolo, Rudolf Kaaks

ABSTRACT

Objective: To investigate the association of prediagnostic circulating levels of C-peptide, as a marker of pancreatic insulin secretion, and IGF binding proteins -1 and -2, as indicators of the biologically active IGF-I concentration, with risk of developing ovarian cancer. Methods: The study was nested within three prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). Case subjects were 132 women with primary invasive epithelial ovarian cancer diagnosed at least one year after blood donation. For each case, two control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study. Results: Odds ratios and their 95% confidence intervals for risk of developing ovarian cancer over quartiles of peptides concentrations after adjustment for BMI and fasting were: 1.00, 0.66 (0.35–1.23), 0.96 (0.51–1.82) and 0.89 (0.44–1.81) for C-peptide; 1.00, 1.10 (0.58–2.09), 1.07 (0.55–2.04) and 0.79 (0.38–1.62) for IGFBP-1; and 1.00, 1.01 (0.54–1.89), 0.98 (0.51–1.88) and 0.87 (0.45–1.68) for IGFBP-2. In women who had ovarian cancer diagnosis before age 55 the ORs for the top tertiles of IGFBP-1 and IGFBP-2 were 0.51 (0.18–1.49) and 0.53 (0.18–1.54), respectively. Conclusions: This study does not support an independent direct etiological role of C-peptide in ovarian cancer pathogenesis, but suggests a possible protective effect of circulating IGFBP-1 and -2 in women who develop ovarian cancer before age 55. More... »

PAGES

285-292

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1023688603547

DOI

http://dx.doi.org/10.1023/a:1023688603547

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022775697

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12814208


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27 schema:description Objective: To investigate the association of prediagnostic circulating levels of C-peptide, as a marker of pancreatic insulin secretion, and IGF binding proteins -1 and -2, as indicators of the biologically active IGF-I concentration, with risk of developing ovarian cancer. Methods: The study was nested within three prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). Case subjects were 132 women with primary invasive epithelial ovarian cancer diagnosed at least one year after blood donation. For each case, two control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study. Results: Odds ratios and their 95% confidence intervals for risk of developing ovarian cancer over quartiles of peptides concentrations after adjustment for BMI and fasting were: 1.00, 0.66 (0.35–1.23), 0.96 (0.51–1.82) and 0.89 (0.44–1.81) for C-peptide; 1.00, 1.10 (0.58–2.09), 1.07 (0.55–2.04) and 0.79 (0.38–1.62) for IGFBP-1; and 1.00, 1.01 (0.54–1.89), 0.98 (0.51–1.88) and 0.87 (0.45–1.68) for IGFBP-2. In women who had ovarian cancer diagnosis before age 55 the ORs for the top tertiles of IGFBP-1 and IGFBP-2 were 0.51 (0.18–1.49) and 0.53 (0.18–1.54), respectively. Conclusions: This study does not support an independent direct etiological role of C-peptide in ovarian cancer pathogenesis, but suggests a possible protective effect of circulating IGFBP-1 and -2 in women who develop ovarian cancer before age 55.
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34 C-peptide
35 IGF
36 IGF-I concentrations
37 IGFBP-1
38 IGFBP-2
39 Milan
40 New York
41 ORs
42 Umeå
43 York
44 adjustment
45 age
46 age 55
47 association
48 association of prediagnostic
49 blood donation
50 cancer
51 cancer diagnosis
52 cancer pathogenesis
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62 direct etiological role
63 donation
64 effect
65 epithelial ovarian cancer
66 etiological role
67 exogenous hormones
68 factors
69 growth factor
70 hormone
71 indicators
72 insulin secretion
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74 interval
75 invasive epithelial ovarian cancer
76 levels
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78 menopausal status
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80 only women
81 ovarian cancer
82 ovarian cancer diagnosis
83 ovarian cancer pathogenesis
84 pancreatic insulin secretion
85 pathogenesis
86 peptide concentration
87 possible protective effect
88 prediagnostic
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90 primary invasive epithelial ovarian cancer
91 prospective cohort
92 protective effect
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