Heparin-binding EGF-like Growth Factor is seen on the Extracellular Surface of Uterine Epithelial Cells only after the Initial Stages of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-07

AUTHORS

Jacqueline Isaacs, Christopher R. Murphy

ABSTRACT

The presence and distribution of heparin-binding epidermal growth factor in rat uterine epithelial cells was determined immunohistochemically and localized ultrastructurally. Rat uterine tissue was examined on days 1, 3, 6 and 8 of pregnancy and it was found that while presence of this growth factor was evident from day 1, spatial reorganization occurred by the time of blastocyst implantation. Strong apical staining was evident from day 6 to day 8, day 6 being the approximate time of blastocyst implantation. Electron microscopy further revealed that this growth factor while shown to be expressed very strongly apically from day 6, actually localized on the plasma membrane only after attachment of the blastocyst. This suggests that heparin-binding epidermal growth factor is not involved in the initial stages of implantation but is more likely involved in the post attachment stages of pregnancy. More... »

PAGES

339-343

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1023334727288

DOI

http://dx.doi.org/10.1023/a:1023334727288

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052477724

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12769266


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