HLA-DRB1 Alleles Contribute to Determining the Prognosis of Japanese Diabetes Mellitus Positive for Antibodies to Glutamate Decarboxylase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-01

AUTHORS

Michiaki Fukui, Koji Nakano, Naoto Nakamura, Etsuko Maruya, Hiroh Saji, Hiroshi Obayashi, Kiyoe Ohta, Mitsuhiro Ohta, Hiroshi Mori, Shizuo Kajiyama, Shigeo Wada, Yasuo Kida, Kitaro Kosaka, Masako Deguchi, Hirofumi Shigeta, Yoshihiro Kitagawa, Motoharu Kondo

ABSTRACT

Diabetes mellitus positive for antibodies to glutamate decarboxylase is heterogeneous as far as the degree of impairment of endogenous insulin release, though antibodies to glutamate decarboxylase are the most useful marker for future insulin deficiency. To investigate what determines the prognosis of diabetes mellitus positive for antibodies to glutamate decarboxylase, we measured HLA-DRB1 alleles in three groups: 77 cases of insulin-dependent diabetes mellitus (IDDM), 44 of non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure of oral hypoglycemic therapy, and 22 of NIDDM well controlled by diet and/or sulfonylurea agents. The proportion of susceptible and resistant alleles to IDDM determined the degree of insulin deficiency, and comparison of IDDM to NIDDM well controlled by diet and/or sulfonylurea agents revealed significant differences in DRB1*0405 (P < 0.05; RR = 2.82 and RR = 0.89, respectively) and DRB1*1502 (P < 0.001; RR = 0.02 and RR = 2.19, respectively). This study revealed that HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase. More... »

PAGES

89-92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1023248106674

DOI

http://dx.doi.org/10.1023/a:1023248106674

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012624439

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9475358


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29 schema:description Diabetes mellitus positive for antibodies to glutamate decarboxylase is heterogeneous as far as the degree of impairment of endogenous insulin release, though antibodies to glutamate decarboxylase are the most useful marker for future insulin deficiency. To investigate what determines the prognosis of diabetes mellitus positive for antibodies to glutamate decarboxylase, we measured HLA-DRB1 alleles in three groups: 77 cases of insulin-dependent diabetes mellitus (IDDM), 44 of non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure of oral hypoglycemic therapy, and 22 of NIDDM well controlled by diet and/or sulfonylurea agents. The proportion of susceptible and resistant alleles to IDDM determined the degree of insulin deficiency, and comparison of IDDM to NIDDM well controlled by diet and/or sulfonylurea agents revealed significant differences in DRB1*0405 (P < 0.05; RR = 2.82 and RR = 0.89, respectively) and DRB1*1502 (P < 0.001; RR = 0.02 and RR = 2.19, respectively). This study revealed that HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase.
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37 NIDDM
38 agents
39 alleles
40 antibodies
41 cases
42 comparison
43 decarboxylase
44 deficiency
45 degree
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47 dependent diabetes mellitus
48 diabetes mellitus
49 diet
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52 failure
53 future insulin deficiency
54 glutamate decarboxylase
55 group
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61 markers
62 mellitus
63 oral hypoglycemic therapy
64 positives
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67 release
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