Microcephaly and Macrocephaly in Autism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

Eric Fombonne, Bernadette Rogé, Jacques Claverie, Stéphanie Courty, Jeanne Frémolle

ABSTRACT

Data from a series of 126 autistic children ages 2-16 years and referred to an Autism Diagnosis Unit in South-West France were examined. Macrocephaly (head circumference > 97th centile) was observed in 16.7% of the sample, a significantly higher proportion than that expected. Macrocephaly was more frequent among older subjects but was otherwise not associated with gender, developmental level, the presence of epilepsy or of medical disorders, or severity of autistic symptomatology. Microcephaly (head circumference < 3rd centile) was also significantly raised and found in 15.1% of the sample. Microcephaly was significantly associated with the presence of medical disorders. Results support those from recent studies suggesting a raised rate of macrocephaly in autism which, pooling published data, can be estimated to be 20%. It is argued that the raised incidence of microcephaly among low-functioning autistic subjects with medical disorders might have contributed to delay the recognition of an increased head circumference among a minority of subjects with idiopathic autism. More... »

PAGES

113-119

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1023036509476

DOI

http://dx.doi.org/10.1023/a:1023036509476

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022592980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10382131


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