Interactions of Nabumetone with Cyclodextrins in Solution and in the Solid State View Full Text


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Article Info

DATE

2002-12

AUTHORS

Nerea Goyenechea, Miguel Sánchez, Itziar Vélaz, Carmen Martín, Cristina Martínez-Ohárriz, Arantxa Zornoza

ABSTRACT

The interactions of nabumetone (NAB) with α-cyclodextrin (α-CD) andγ-cyclodextrin (γ-CD) were studied in aqueous solution by meansof phase-solubility analysis. Solid dispersions of NAB with α-cyclodextrin(α-CD), β-cyclodextrin (β-CD), methylβ- (Mβ-CD),hydroxypropylβ-cyclodextrin (HPβ-CD) were prepared by coevaporationand kneading and also by coprecipitation in the case of γ-CD. X-ray diffractometry, thermal analysis and infrared spectroscopy (FTIR) were used to study the possibility of complexation of the drug with the different cyclodextrins. Solid dispersions of nabumetone with γ-CD showed a remarkable improvement in the dissolution rate of nabumetone. More... »

PAGES

283-288

References to SciGraph publications

  • 1984-09. Interaction of tri-O-methyl-β-cyclodextrin with drugs in JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1023016114329

    DOI

    http://dx.doi.org/10.1023/a:1023016114329

    DIMENSIONS

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