Titanium implants and BMP-7 in bone: an experimental model in the rabbit View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03

AUTHORS

V. Franke Stenport, C. Johansson, S. Joo Heo, P. Aspenberg, T. Albrektsson

ABSTRACT

This study evaluates the effect of rhBMP-7/OP-1 on the osseointegration of commercially pure titanium implants in an experimental implant model in rabbits. Threaded titanium implants with two transverse parallel canals were inserted in the femur and tibia of rabbits. The canals were filled with, 10 microg of BMP-7/collagen carrier, pure collagen carrier or were left empty as a control. The stiffness of the implant fixation was evaluated by Resonance Frequency Analysis (RFA) at baseline and four weeks postoperatively. Percentage of bone ingrowth in the canals was measured on microradiographs. Histomorphometry along the threaded part of the implants was performed on 15 microm thin sections. The results from the RFA demonstrated a higher mean value for the BMP-7 treated implants in the tibia than the carrier treated implants but not compared to the control implants. The control implants in the tibia demonstrated more bone ingrowth in the upper canal than to the carrier or the BMP-7 treated implants. Apart from these differences there were no significant effects of BMP. In this study BMP-7 did not contribute to any substantially improved bone anchorage of titanium implants. More... »

PAGES

247-254

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1022884724059

DOI

http://dx.doi.org/10.1023/a:1022884724059

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024132149

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15348471


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