Dynamic tests and FSH biological activity in female rats with acute nephrotic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03

AUTHORS

María Guadalupe Ortiz-López, Mario Cárdenas, Teresa Zariñán, Laura Díaz-Bonilla, Elena Zambrano, José Pedraza-Chaverrí, Marta Menjívar

ABSTRACT

To investigate the pituitary-ovarian status during the acute state of the nephrotic syndrome, a sequence of experiments were undertaken in adult female rats after a single dose of the puromycin aminonucleoside (PAN). The functional condition of the hypophyseal-ovarian unit was determined in control and nephrotic rats by two dynamic tests. In the first one, 10 days after PAN or placebo administration female rats were stimulated with LHRH (300 ng/100 g body wt) and samples were collected at 0, 20, 40, 60 and 80 min after releasing factor administration. The second dynamic test, which was performed in control and nephrotic rats, consists of one (day 10 after PAN) or four (between days 7–10 after PAN) doses of hCG (8 UI), respectively. In all cases, serum samples were collected on day 10. In addition, the relative in vitro biological activity of FSH from control and nephrotic rats before and after LHRH stimulus was determined. The results reveal that after a stimulatory dose of LHRH the secretion of LH was significantly diminished in nephrotic rats at all registered times. By contrast, normal response was observed in terms of FSH secretion in nephrotic females. On the other hand, no ovarian response, in terms of progesterone or estradiol synthesis, was observed in nephrotic rats after either one or four stimuli with hCG. Interestingly, in spite of the normal or high concentrations of FSH, the biological activity of FSH was totally abolished in nephrotic rats. On the whole, the results from this study indicate that the nephrotic syndrome had a harmful effect on the pituitary-ovarian unit, and strongly suggest that the endocrine dysfunction could be initiated at the hypophysial level; even though a specific ovarian damage is also predictable. More... »

PAGES

167-172

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1022880414635

DOI

http://dx.doi.org/10.1023/a:1022880414635

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017944038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12708756


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