Inhibition of Lung Colonisation of a Mouse Mammary Carcinoma by Therapeutic Vaccination with Interferon-α Gene-Transduced Tumor Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

Ilaria Rossi, Giordano Nicoletti, Lorena Landuzzi, Flavia Frabetti, Carla De Giovanni, Patrizia Nanni, Piero Musiani, Maria Ferrantini, Filippo Belardelli, Pier-Luigi Lollini

ABSTRACT

A spontaneously metastatic murine mammary adenocarcinoma, TSA, has been transduced with the gene for interferon alpha1 (IFN-alpha). Transfectants were used for the immunotherapy of mice bearing lung colonies induced by the intravenous inoculation of non-transduced parental cells. A significant reduction in the number of tumor colonies was obtained when repeated subcutaneous administrations of mitomycin C-blocked transfectant cells were given, commencing 3 days after an intravenous challenge with TSA cells. Intraperitoneal vaccination induced a stronger anti-tumor response than subcutaneous vaccination, and the proportion of tumor-free mice reached 50%. The potency of IFN-alpha transfectants was similar to that of IFN-gamma transfectants previously obtained from TSA. Admixture of IFN-alpha and IFN-gamma transfectant cells in the same vaccine did not increase the curative effect over that of single vaccines. In nude mice vaccination with IFN-alpha or IFN-gamma transfectants did not lead to a reduction in the number of lung colonies, indicating that an intact T cell response was required for the therapeutic effect observed in immunocompetent mice. More... »

PAGES

123

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1021980818017

DOI

http://dx.doi.org/10.1023/a:1021980818017

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040203564

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9514093


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cancer Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intraperitoneal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Subcutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transduction, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Ilaria", 
        "id": "sg:person.0710271645.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710271645.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicoletti", 
        "givenName": "Giordano", 
        "id": "sg:person.01052142471.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052142471.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landuzzi", 
        "givenName": "Lorena", 
        "id": "sg:person.01030263515.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030263515.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frabetti", 
        "givenName": "Flavia", 
        "id": "sg:person.0602260763.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602260763.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Giovanni", 
        "givenName": "Carla", 
        "id": "sg:person.01027226732.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027226732.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nanni", 
        "givenName": "Patrizia", 
        "id": "sg:person.01076376715.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076376715.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Human Pathology and Social Medicine, University of Chieti, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Musiani", 
        "givenName": "Piero", 
        "id": "sg:person.01211570532.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211570532.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, ISS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrantini", 
        "givenName": "Maria", 
        "id": "sg:person.01272007632.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272007632.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Virology, ISS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belardelli", 
        "givenName": "Filippo", 
        "id": "sg:person.077031223.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077031223.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Cancer Research, University of Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lollini", 
        "givenName": "Pier-Luigi", 
        "id": "sg:person.01144245317.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144245317.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0167-5699(96)10027-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010417999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010763270", 
          "https://doi.org/10.1038/bjc.1996.590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010763270", 
          "https://doi.org/10.1038/bjc.1996.590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1995.tb01092.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012573690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1995.tb01092.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012573690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.13.926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021112213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910550224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021140367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(86)90727-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026090328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00121199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034082810", 
          "https://doi.org/10.1007/bf00121199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00121199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034082810", 
          "https://doi.org/10.1007/bf00121199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90131-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036268443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(94)90131-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036268443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.163.4.1030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041585196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910400621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049570138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(97)80012-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052593833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7761853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077820363", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080038170", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/36.4.641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080163485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082382842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082430738", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082581491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082584685", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082862829", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.2.343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082888176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083178989", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "A spontaneously metastatic murine mammary adenocarcinoma, TSA, has been transduced with the gene for interferon alpha1 (IFN-alpha). Transfectants were used for the immunotherapy of mice bearing lung colonies induced by the intravenous inoculation of non-transduced parental cells. A significant reduction in the number of tumor colonies was obtained when repeated subcutaneous administrations of mitomycin C-blocked transfectant cells were given, commencing 3 days after an intravenous challenge with TSA cells. Intraperitoneal vaccination induced a stronger anti-tumor response than subcutaneous vaccination, and the proportion of tumor-free mice reached 50%. The potency of IFN-alpha transfectants was similar to that of IFN-gamma transfectants previously obtained from TSA. Admixture of IFN-alpha and IFN-gamma transfectant cells in the same vaccine did not increase the curative effect over that of single vaccines. In nude mice vaccination with IFN-alpha or IFN-gamma transfectants did not lead to a reduction in the number of lung colonies, indicating that an intact T cell response was required for the therapeutic effect observed in immunocompetent mice.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1021980818017", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094856", 
        "issn": [
          "0262-0898", 
          "1573-7276"
        ], 
        "name": "Clinical & Experimental Metastasis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Inhibition of Lung Colonisation of a Mouse Mammary Carcinoma by Therapeutic Vaccination with Interferon-\u03b1 Gene-Transduced Tumor Cells", 
    "pagination": "123", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bf83de46825e3a89f22de517c509115abe9135fe32296aac7954b30ffc3cc803"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9514093"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409970"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1021980818017"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040203564"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1021980818017", 
      "https://app.dimensions.ai/details/publication/pub.1040203564"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000507.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FA%3A1021980818017"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1021980818017'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1021980818017'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1021980818017'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1021980818017'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      68 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1021980818017 schema:about N0a9280f9a1ca41589aaa609ce408604a
2 N1ba02a313f4d476fa9b3fbb98805f782
3 N2229faeab69347dea75975e00779766d
4 N2384187bcd3c415aa07edc29de248887
5 N48a2262bdc9a49b4aab72d3ea0bbecd6
6 N569aacd923cf49528339cc6d84034459
7 N896ac2d338ba4ee8b66859b7f9f510e3
8 N8fa2816a83864e429cb9e6f84440f583
9 Na6fa391a6a5e4ff7acd6ce559d3a836b
10 Nb3e7c46bee7549de930dc3598ab4369b
11 Nb80058833a3a4d49a83c9d5e2daa7b23
12 Nb8ddf5dd625149fc894f036280b36284
13 Nc9d8ece475754aa8b0a4a6d7925b9f1f
14 Nc9fc6177031240a39c43978a18735173
15 Nd96cda244ec7464896be86391eaca241
16 Nefcc4b77ff9446a3b52ce5dcdba09be1
17 Nf15ec3dc84874596aaf5a7f8c196c8c0
18 anzsrc-for:11
19 anzsrc-for:1107
20 schema:author Ne7930eb99b444070bc9339f2d09f9868
21 schema:citation sg:pub.10.1007/bf00121199
22 sg:pub.10.1038/bjc.1996.590
23 https://app.dimensions.ai/details/publication/pub.1077820363
24 https://app.dimensions.ai/details/publication/pub.1080038170
25 https://app.dimensions.ai/details/publication/pub.1082382842
26 https://app.dimensions.ai/details/publication/pub.1082430738
27 https://app.dimensions.ai/details/publication/pub.1082581491
28 https://app.dimensions.ai/details/publication/pub.1082584685
29 https://app.dimensions.ai/details/publication/pub.1082862829
30 https://app.dimensions.ai/details/publication/pub.1083178989
31 https://doi.org/10.1002/ijc.2910400621
32 https://doi.org/10.1002/ijc.2910550224
33 https://doi.org/10.1016/0006-291x(86)90727-8
34 https://doi.org/10.1016/0167-5699(94)90131-7
35 https://doi.org/10.1016/0167-5699(96)10027-x
36 https://doi.org/10.1016/s0167-5699(97)80012-6
37 https://doi.org/10.1084/jem.163.4.1030
38 https://doi.org/10.1093/jnci/36.4.641
39 https://doi.org/10.1093/jnci/88.13.926
40 https://doi.org/10.1111/j.1699-0463.1995.tb01092.x
41 https://doi.org/10.1126/science.7761853
42 https://doi.org/10.1200/jco.1996.14.2.343
43 schema:datePublished 1998-02
44 schema:datePublishedReg 1998-02-01
45 schema:description A spontaneously metastatic murine mammary adenocarcinoma, TSA, has been transduced with the gene for interferon alpha1 (IFN-alpha). Transfectants were used for the immunotherapy of mice bearing lung colonies induced by the intravenous inoculation of non-transduced parental cells. A significant reduction in the number of tumor colonies was obtained when repeated subcutaneous administrations of mitomycin C-blocked transfectant cells were given, commencing 3 days after an intravenous challenge with TSA cells. Intraperitoneal vaccination induced a stronger anti-tumor response than subcutaneous vaccination, and the proportion of tumor-free mice reached 50%. The potency of IFN-alpha transfectants was similar to that of IFN-gamma transfectants previously obtained from TSA. Admixture of IFN-alpha and IFN-gamma transfectant cells in the same vaccine did not increase the curative effect over that of single vaccines. In nude mice vaccination with IFN-alpha or IFN-gamma transfectants did not lead to a reduction in the number of lung colonies, indicating that an intact T cell response was required for the therapeutic effect observed in immunocompetent mice.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N16012c3c57d24536a3e35bac1173da64
50 Nc034509148d74f22ae651336a72fe152
51 sg:journal.1094856
52 schema:name Inhibition of Lung Colonisation of a Mouse Mammary Carcinoma by Therapeutic Vaccination with Interferon-α Gene-Transduced Tumor Cells
53 schema:pagination 123
54 schema:productId N4fa2e8e68ac443a98817589f8a607c51
55 N961f185602d54a1f95eded185fcd7180
56 Naa61b00fe7804a0c91ca9a4998801ca2
57 Ndddf7237541842aba8035a4424db016a
58 Nfafebcd4528040c88b4a476f68dab2f9
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040203564
60 https://doi.org/10.1023/a:1021980818017
61 schema:sdDatePublished 2019-04-10T23:23
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N85a93fc2666b4ccab9a83aca5c88d5d2
64 schema:url http://link.springer.com/10.1023%2FA%3A1021980818017
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0a9280f9a1ca41589aaa609ce408604a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Injections, Intraperitoneal
70 rdf:type schema:DefinedTerm
71 N16012c3c57d24536a3e35bac1173da64 schema:volumeNumber 16
72 rdf:type schema:PublicationVolume
73 N1ba02a313f4d476fa9b3fbb98805f782 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Mammary Neoplasms, Experimental
75 rdf:type schema:DefinedTerm
76 N2229faeab69347dea75975e00779766d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Interferon-gamma
78 rdf:type schema:DefinedTerm
79 N2384187bcd3c415aa07edc29de248887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Mice, Nude
81 rdf:type schema:DefinedTerm
82 N273803f89ac24a019001af1328b2869d rdf:first sg:person.01052142471.34
83 rdf:rest N568ba5c305e045338c7fe35b1d5047db
84 N48a2262bdc9a49b4aab72d3ea0bbecd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Animals
86 rdf:type schema:DefinedTerm
87 N4fa2e8e68ac443a98817589f8a607c51 schema:name doi
88 schema:value 10.1023/a:1021980818017
89 rdf:type schema:PropertyValue
90 N568ba5c305e045338c7fe35b1d5047db rdf:first sg:person.01030263515.01
91 rdf:rest Na7f56fa11fd34f968c6106612c496595
92 N569aacd923cf49528339cc6d84034459 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Injections, Subcutaneous
94 rdf:type schema:DefinedTerm
95 N5a33e574841a472ab641d81fe720046d schema:name Department of Human Pathology and Social Medicine, University of Chieti, Italy
96 rdf:type schema:Organization
97 N5c8179b6e5e44e8b989bebc2721be0f4 rdf:first sg:person.01076376715.24
98 rdf:rest Nd28fd964c6bb4c8c8c6c3468a185c709
99 N85a93fc2666b4ccab9a83aca5c88d5d2 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N896ac2d338ba4ee8b66859b7f9f510e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cancer Vaccines
103 rdf:type schema:DefinedTerm
104 N8c7459dd4c7949ab95ac9022d8cc8c80 rdf:first sg:person.01027226732.33
105 rdf:rest N5c8179b6e5e44e8b989bebc2721be0f4
106 N8fa2816a83864e429cb9e6f84440f583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Adenocarcinoma
108 rdf:type schema:DefinedTerm
109 N961f185602d54a1f95eded185fcd7180 schema:name dimensions_id
110 schema:value pub.1040203564
111 rdf:type schema:PropertyValue
112 Na6fa391a6a5e4ff7acd6ce559d3a836b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Injections, Intravenous
114 rdf:type schema:DefinedTerm
115 Na7f56fa11fd34f968c6106612c496595 rdf:first sg:person.0602260763.32
116 rdf:rest N8c7459dd4c7949ab95ac9022d8cc8c80
117 Naa61b00fe7804a0c91ca9a4998801ca2 schema:name readcube_id
118 schema:value bf83de46825e3a89f22de517c509115abe9135fe32296aac7954b30ffc3cc803
119 rdf:type schema:PropertyValue
120 Nb3e7c46bee7549de930dc3598ab4369b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 Nb80058833a3a4d49a83c9d5e2daa7b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Interferon-alpha
125 rdf:type schema:DefinedTerm
126 Nb8ddf5dd625149fc894f036280b36284 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mitomycin
128 rdf:type schema:DefinedTerm
129 Nb8fb0cb5d2ce453888d12e89a09e19b7 rdf:first sg:person.01272007632.86
130 rdf:rest Nbc3447b8d8d8421f802e018f39b6455d
131 Nbc3447b8d8d8421f802e018f39b6455d rdf:first sg:person.077031223.43
132 rdf:rest Ndc123df744264b98aeda64bf94c9171b
133 Nc034509148d74f22ae651336a72fe152 schema:issueNumber 2
134 rdf:type schema:PublicationIssue
135 Nc9d8ece475754aa8b0a4a6d7925b9f1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name T-Lymphocytes
137 rdf:type schema:DefinedTerm
138 Nc9fc6177031240a39c43978a18735173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Lung Neoplasms
140 rdf:type schema:DefinedTerm
141 Nd28fd964c6bb4c8c8c6c3468a185c709 rdf:first sg:person.01211570532.16
142 rdf:rest Nb8fb0cb5d2ce453888d12e89a09e19b7
143 Nd96cda244ec7464896be86391eaca241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice
145 rdf:type schema:DefinedTerm
146 Ndc123df744264b98aeda64bf94c9171b rdf:first sg:person.01144245317.09
147 rdf:rest rdf:nil
148 Ndddf7237541842aba8035a4424db016a schema:name pubmed_id
149 schema:value 9514093
150 rdf:type schema:PropertyValue
151 Ne7930eb99b444070bc9339f2d09f9868 rdf:first sg:person.0710271645.35
152 rdf:rest N273803f89ac24a019001af1328b2869d
153 Nefcc4b77ff9446a3b52ce5dcdba09be1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Transduction, Genetic
155 rdf:type schema:DefinedTerm
156 Nf15ec3dc84874596aaf5a7f8c196c8c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice, Inbred BALB C
158 rdf:type schema:DefinedTerm
159 Nfafebcd4528040c88b4a476f68dab2f9 schema:name nlm_unique_id
160 schema:value 8409970
161 rdf:type schema:PropertyValue
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
166 schema:name Immunology
167 rdf:type schema:DefinedTerm
168 sg:journal.1094856 schema:issn 0262-0898
169 1573-7276
170 schema:name Clinical & Experimental Metastasis
171 rdf:type schema:Periodical
172 sg:person.01027226732.33 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
173 schema:familyName De Giovanni
174 schema:givenName Carla
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027226732.33
176 rdf:type schema:Person
177 sg:person.01030263515.01 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
178 schema:familyName Landuzzi
179 schema:givenName Lorena
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030263515.01
181 rdf:type schema:Person
182 sg:person.01052142471.34 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
183 schema:familyName Nicoletti
184 schema:givenName Giordano
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052142471.34
186 rdf:type schema:Person
187 sg:person.01076376715.24 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
188 schema:familyName Nanni
189 schema:givenName Patrizia
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076376715.24
191 rdf:type schema:Person
192 sg:person.01144245317.09 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
193 schema:familyName Lollini
194 schema:givenName Pier-Luigi
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144245317.09
196 rdf:type schema:Person
197 sg:person.01211570532.16 schema:affiliation N5a33e574841a472ab641d81fe720046d
198 schema:familyName Musiani
199 schema:givenName Piero
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211570532.16
201 rdf:type schema:Person
202 sg:person.01272007632.86 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
203 schema:familyName Ferrantini
204 schema:givenName Maria
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272007632.86
206 rdf:type schema:Person
207 sg:person.0602260763.32 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
208 schema:familyName Frabetti
209 schema:givenName Flavia
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602260763.32
211 rdf:type schema:Person
212 sg:person.0710271645.35 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
213 schema:familyName Rossi
214 schema:givenName Ilaria
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710271645.35
216 rdf:type schema:Person
217 sg:person.077031223.43 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
218 schema:familyName Belardelli
219 schema:givenName Filippo
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077031223.43
221 rdf:type schema:Person
222 sg:pub.10.1007/bf00121199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034082810
223 https://doi.org/10.1007/bf00121199
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/bjc.1996.590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010763270
226 https://doi.org/10.1038/bjc.1996.590
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1077820363 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1080038170 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1082382842 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1082430738 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1082581491 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082584685 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082862829 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1083178989 schema:CreativeWork
236 https://doi.org/10.1002/ijc.2910400621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049570138
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/ijc.2910550224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021140367
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0006-291x(86)90727-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026090328
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0167-5699(94)90131-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036268443
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0167-5699(96)10027-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010417999
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0167-5699(97)80012-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052593833
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1084/jem.163.4.1030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041585196
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/jnci/36.4.641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080163485
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/jnci/88.13.926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021112213
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1699-0463.1995.tb01092.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012573690
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1126/science.7761853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649193
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.1996.14.2.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082888176
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.416651.1 schema:alternateName Istituto Superiore di Sanità
261 schema:name Laboratory of Virology, ISS, Rome, Italy
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.6292.f schema:alternateName University of Bologna
264 schema:name Institute of Cancer Research, University of Bologna, Italy
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...