Participation of the Cholinergic System in the Excessive Grooming Behavior Induced by Neuropeptide (N) Glutamic Acid (E) Isoleucine (I) Amide ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-12

AUTHORS

Victoria Berberian, Mónica Silvina Sanchez, María Ester Celis

ABSTRACT

The neuropeptide (N) glutamic acid (E) isoleucine (I) amide (NEI) injected into the ventral tegmental area (VTA) or intraventricularly (icv) induces excessive grooming behavior (EGB) and motor activity (MA). Here, we studied whether the cholinergic system is involved in the NEI-induced behavior. The present results demonstrate that atropine, a general muscarinic antagonist, injected icv previous to NEI, suppresses the behavior provoked by icv injections of the peptide, whereas the prior icv injection of dyhidro-β-erythroidine, a general nicotinic antagonist, did not affect the EGB and MA induced by the peptide. From the experimental evidence, it is suggested that NEI may act specifically on a cholinergic afferent to dopaminergic cells. Also, the results appear to indicate that a neural target, different from the dopamine system, may be activated by the peptide to elicit behavioral changes, such as EGB. More... »

PAGES

1713-1717

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1021655631754

DOI

http://dx.doi.org/10.1023/a:1021655631754

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040698110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12515327


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