Water-Soluble Polymer–Ferrocene Conjugates Based on Polyamide Carriers Containing Intrachain-Type Secondary Amine Functions as Binding Sites View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-12

AUTHORS

Maria G. Meirim, Eberhard W. Neuse, Gregg Caldwell

ABSTRACT

It is the objective of this project to synthesize polymer–ferrocene conjugates from macromolecular carriers in which the “anchoring” sites are main-chain constituents, thus contrasting with previously described conjugates featuring side-chain terminals as anchoring sites. To this end, earlier-developed polyamide carriers containing secondary amino groups in the main chain are treated with the active N-succinimidyl ester of 4-ferrocenylbutanoic acid in DMF solution. Molar feed ratios are chosen so as to favor the incorporation of a single ferrocenyl group per recurring unit. The water-soluble, microanalytically and spectroscopically characterized conjugates are of interest as antiproliferative agents in cancer research. More... »

PAGES

225-236

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1021436126927

DOI

http://dx.doi.org/10.1023/a:1021436126927

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011889476


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