Decreases in Plasma Aβ1-40 Levels with Aging in Non-Demented Elderly with ApoE-ε4 Allele View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-12

AUTHORS

Nunzio Pomara, Binbin Shao, Thomas Wisniewski, Pankaj D. Mehta

ABSTRACT

This report examines plasma amyloid beta proteins A beta 40 and A beta 42 and apolipoprotein E (apoE) levels and their relationships with age in non-demented older adults with (N = 32) or without the apoE-epsilon 4 allele (N = 94). A beta levels did not differ between the groups whereas the epsilon 4 allele was associated with a significant reduction in plasma apoE. In subjects with the epsilon 4 allele, increasing age was associated with significant reduction in plasma A beta 40. Subjects without the epsilon 4 allele showed a significant positive correlation between A beta 40 and A beta 42 levels. There was also a significant correlation between plasma A beta 40 and apoE levels in all subjects. More... »

PAGES

1563-1566

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1020936222286

DOI

http://dx.doi.org/10.1023/a:1020936222286

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011367685

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9821162


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