Presynaptic Effect of Ethosuximide: a Study on a Cell-Free Model System View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

L. Gromov, L. Syrovatska, V. Gumenyuk, I. Trikash

ABSTRACT

The effect of an antiepileptic drug, ethosuximide, on fusion of synaptic vesicles with the synaptosomal plasma membranes was studied. It was shown that ethosuximide increases the rate of the Ca2+-dependent fusion reaction. We found that ethosuximide-induced fusion of synaptic vesicles with the plasma membrane in a Ca2+-free medium is much lower than the Ca2+-induced effect under the same conditions. Thus, the fusion-inducing effect of ethosuximide is mostly Ca2+-dependent. Ethosuximide-evoked fusion was suppressed by pentylenetetrazole. More... »

PAGES

141-143

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1020762107801

DOI

http://dx.doi.org/10.1023/a:1020762107801

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004631889


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0202", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Atomic, Molecular, Nuclear, Particle and Plasma Physics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Academy of Medical Sciences of Ukraine", 
          "id": "https://www.grid.ac/institutes/grid.419973.1", 
          "name": [
            "Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gromov", 
        "givenName": "L.", 
        "id": "sg:person.01101343454.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101343454.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Academy of Medical Sciences of Ukraine", 
          "id": "https://www.grid.ac/institutes/grid.419973.1", 
          "name": [
            "Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Syrovatska", 
        "givenName": "L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gumenyuk", 
        "givenName": "V.", 
        "id": "sg:person.01137345775.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137345775.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trikash", 
        "givenName": "I.", 
        "id": "sg:person.060040255.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.060040255.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0959-4388(99)80047-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008069427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02462825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021966742", 
          "https://doi.org/10.1007/bf02462825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02462825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021966742", 
          "https://doi.org/10.1007/bf02462825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90376-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037094317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02461243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049294149", 
          "https://doi.org/10.1007/bf02461243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02461243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049294149", 
          "https://doi.org/10.1007/bf02461243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00319a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055169996"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-03", 
    "datePublishedReg": "2002-03-01", 
    "description": "The effect of an antiepileptic drug, ethosuximide, on fusion of synaptic vesicles with the synaptosomal plasma membranes was studied. It was shown that ethosuximide increases the rate of the Ca2+-dependent fusion reaction. We found that ethosuximide-induced fusion of synaptic vesicles with the plasma membrane in a Ca2+-free medium is much lower than the Ca2+-induced effect under the same conditions. Thus, the fusion-inducing effect of ethosuximide is mostly Ca2+-dependent. Ethosuximide-evoked fusion was suppressed by pentylenetetrazole.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1023/a:1020762107801", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016854", 
        "issn": [
          "0090-2977", 
          "1573-9007"
        ], 
        "name": "Neurophysiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2-3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Presynaptic Effect of Ethosuximide: a Study on a Cell-Free Model System", 
    "pagination": "141-143", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1612116d720e83d7a4c8c37a9f0290a2ddf279983b91bcf03274bd2a24480751"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1020762107801"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004631889"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1020762107801", 
      "https://app.dimensions.ai/details/publication/pub.1004631889"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023%2FA%3A1020762107801"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1020762107801'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1020762107801'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1020762107801'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1020762107801'


 

This table displays all metadata directly associated to this object as RDF triples.

101 TRIPLES      21 PREDICATES      32 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1020762107801 schema:about anzsrc-for:02
2 anzsrc-for:0202
3 schema:author N6843dbabe83848239e5edd264caa45d6
4 schema:citation sg:pub.10.1007/bf02461243
5 sg:pub.10.1007/bf02462825
6 https://doi.org/10.1016/0092-8674(93)90376-2
7 https://doi.org/10.1016/s0959-4388(99)80047-6
8 https://doi.org/10.1021/bi00319a002
9 schema:datePublished 2002-03
10 schema:datePublishedReg 2002-03-01
11 schema:description The effect of an antiepileptic drug, ethosuximide, on fusion of synaptic vesicles with the synaptosomal plasma membranes was studied. It was shown that ethosuximide increases the rate of the Ca2+-dependent fusion reaction. We found that ethosuximide-induced fusion of synaptic vesicles with the plasma membrane in a Ca2+-free medium is much lower than the Ca2+-induced effect under the same conditions. Thus, the fusion-inducing effect of ethosuximide is mostly Ca2+-dependent. Ethosuximide-evoked fusion was suppressed by pentylenetetrazole.
12 schema:genre non_research_article
13 schema:inLanguage en
14 schema:isAccessibleForFree false
15 schema:isPartOf N97b475429d234d89adc3063ea51012b5
16 Nd7c2c56a55aa4887b55bcbde25f0b6ec
17 sg:journal.1016854
18 schema:name Presynaptic Effect of Ethosuximide: a Study on a Cell-Free Model System
19 schema:pagination 141-143
20 schema:productId N93d64c217b7d409c8f571cada59353fc
21 N9471a3569c84468488a4a330d7d43493
22 N96045afaeb2345808b5ec8044e64b69c
23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004631889
24 https://doi.org/10.1023/a:1020762107801
25 schema:sdDatePublished 2019-04-10T14:07
26 schema:sdLicense https://scigraph.springernature.com/explorer/license/
27 schema:sdPublisher N71eadd73177b4c8bb4ff10e22eec308d
28 schema:url http://link.springer.com/10.1023%2FA%3A1020762107801
29 sgo:license sg:explorer/license/
30 sgo:sdDataset articles
31 rdf:type schema:ScholarlyArticle
32 N6300181437bc4482b063e27e5d6ef29c rdf:first sg:person.01137345775.17
33 rdf:rest N70ee4ecd35e64d83889972a5f04efc9b
34 N6843dbabe83848239e5edd264caa45d6 rdf:first sg:person.01101343454.71
35 rdf:rest N7a6dcce24b7948eab6a48721747a8a4a
36 N70ee4ecd35e64d83889972a5f04efc9b rdf:first sg:person.060040255.77
37 rdf:rest rdf:nil
38 N71eadd73177b4c8bb4ff10e22eec308d schema:name Springer Nature - SN SciGraph project
39 rdf:type schema:Organization
40 N7a6dcce24b7948eab6a48721747a8a4a rdf:first N81544dd9755b4eb5be7e4acc8ca05848
41 rdf:rest N6300181437bc4482b063e27e5d6ef29c
42 N81544dd9755b4eb5be7e4acc8ca05848 schema:affiliation https://www.grid.ac/institutes/grid.419973.1
43 schema:familyName Syrovatska
44 schema:givenName L.
45 rdf:type schema:Person
46 N93d64c217b7d409c8f571cada59353fc schema:name dimensions_id
47 schema:value pub.1004631889
48 rdf:type schema:PropertyValue
49 N9471a3569c84468488a4a330d7d43493 schema:name readcube_id
50 schema:value 1612116d720e83d7a4c8c37a9f0290a2ddf279983b91bcf03274bd2a24480751
51 rdf:type schema:PropertyValue
52 N96045afaeb2345808b5ec8044e64b69c schema:name doi
53 schema:value 10.1023/a:1020762107801
54 rdf:type schema:PropertyValue
55 N97b475429d234d89adc3063ea51012b5 schema:volumeNumber 34
56 rdf:type schema:PublicationVolume
57 Nd7c2c56a55aa4887b55bcbde25f0b6ec schema:issueNumber 2-3
58 rdf:type schema:PublicationIssue
59 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
60 schema:name Physical Sciences
61 rdf:type schema:DefinedTerm
62 anzsrc-for:0202 schema:inDefinedTermSet anzsrc-for:
63 schema:name Atomic, Molecular, Nuclear, Particle and Plasma Physics
64 rdf:type schema:DefinedTerm
65 sg:journal.1016854 schema:issn 0090-2977
66 1573-9007
67 schema:name Neurophysiology
68 rdf:type schema:Periodical
69 sg:person.01101343454.71 schema:affiliation https://www.grid.ac/institutes/grid.419973.1
70 schema:familyName Gromov
71 schema:givenName L.
72 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101343454.71
73 rdf:type schema:Person
74 sg:person.01137345775.17 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
75 schema:familyName Gumenyuk
76 schema:givenName V.
77 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137345775.17
78 rdf:type schema:Person
79 sg:person.060040255.77 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
80 schema:familyName Trikash
81 schema:givenName I.
82 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.060040255.77
83 rdf:type schema:Person
84 sg:pub.10.1007/bf02461243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049294149
85 https://doi.org/10.1007/bf02461243
86 rdf:type schema:CreativeWork
87 sg:pub.10.1007/bf02462825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021966742
88 https://doi.org/10.1007/bf02462825
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1016/0092-8674(93)90376-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037094317
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1016/s0959-4388(99)80047-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008069427
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1021/bi00319a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055169996
95 rdf:type schema:CreativeWork
96 https://www.grid.ac/institutes/grid.419966.5 schema:alternateName Palladin Institute of Biochemistry
97 schema:name Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
98 rdf:type schema:Organization
99 https://www.grid.ac/institutes/grid.419973.1 schema:alternateName National Academy of Medical Sciences of Ukraine
100 schema:name Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
101 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...