Presence of an Endogenous Factor in Avian CNS with Agonistic Action on Benzodiazepine Receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-11

AUTHORS

María Clara Gravielle, Clara Peña, Leonardo Pignataro, Sara Fiszer de Plazas

ABSTRACT

In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with C18 cartridges and several HPLC steps until an homogeneous peak was obtained. Its chemical structure was studied by size-exclusion chromatography of the purified material which indicated that it possesses a molecular weight below 1350. Although its inhibitory activity was lost by HCl treatment, its peptidic nature was ruled out by an amino acid and N-terminal sequence analyses. Ultraviolet absorption spectrum showed two main peaks at 230 and 280 nm. The endogenous compound was found to inhibit competitively [3H]flunitrazepam binding to its recognition site without affecting [3H]GABA binding to the same receptor complex. The behavior of the endogenous factor in an "in vitro" GABA "shift" test and GABA-dependent chloride flux experiments were similar to that of benzodiazepine receptor agonists. In conclusion, these results demonstrate the existence in avian CNS of a competitive endogenous inhibitor of benzodiazepine binding with agonistic action on benzodiazepine receptors. More... »

PAGES

1395-1401

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1020702823600

DOI

http://dx.doi.org/10.1023/a:1020702823600

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013325184

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9814550


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