New Approach to Tumor Therapy for Inoperable Areas of the Brain: Chronic Intraparenchymal Drug Delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11

AUTHORS

Benjamin S. Carson, Qingze Wu, Betty Tyler, Lindsey Sukay, Ratul Raychaudhuri, Francesco DiMeco, Richard E. Clatterbuck, Alessandro Olivi, Michael Guarnieri

ABSTRACT

Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 microl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable. More... »

PAGES

151-158

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1020626419269

DOI

http://dx.doi.org/10.1023/a:1020626419269

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046576846

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12635662


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