Kinetics of Lymphokine Production in HIV+ Patients Treated with Highly Active Antiretroviral Therapy and Interleukin 2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-09

AUTHORS

Paolo De Paoli, Stefania Zanussi, Laura Caggiari, Maria Teresa Bortolin, Monica D'andrea, Cecilia Simonelli, Umberto Tirelli

ABSTRACT

This study presents the kinetics of CD4/CD25 cell numbers, serum sCD25 levels, and intracellular production and release of interleukin-2 (IL-2) and interleukin-16 (IL-16) in 11 HIV+ patients treated with six cycles of highly active antiretroviral therapy (HAART) plus six MUI of subcutaneous IL-2 compared to 10 HIV+ patients treated with HAART alone. IL-2 therapy induced moderate effects on CD4 T cell recovery and increased CD4/CD25+ cells and sCD25 levels after 2 weeks, while intracellular and secreted IL-2 was reduced and IL-16 was increased at the same time point. After 24 weeks, while HAART-treated patients had increased IL-2 production, in IL-2 treated patients, cytokine production was unaltered compared to pretreatment values. Decreased in vitro IL-2 production may depend on a feedback inhibition by IL-2 infusion. Because of its known antiviral effects, the increased IL-16 production seen after 2 weeks in IL-2-treated individuals may produce beneficial effects on HIV disease. The kinetics of cytokine production may serve to define better the use IL-2 in clinical trials. More... »

PAGES

317-325

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1020547826191

DOI

http://dx.doi.org/10.1023/a:1020547826191

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020090707

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10535609


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1020547826191'


 

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