Nuclear Factor-κB and TNF-α Mediate Gastric Ulceration Induced by Phorbol Myristate Acetate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Tetsu Takeuchi, Soichiro Miura, Lin Wang, Keita Uehara, Misa Mizumori, Hiroshi Kishikawa, Ryota Hokari, Hajime Higuchi, Masayuki Adachi, Hiromasa Nakamizo, Hiromasa Ishii

ABSTRACT

Phorbol esters induce inflammation in rodents by activating protein kinase C. We determined whether nuclear factor-kappaB (NF-kappaB) and tumor necrosis factor-alpha (TNF-alpha) play role in the formation of gastric ulcer induced by phorbol-12-myristate-13-alphacetate (PMA) in rats. Subserosally injected PMA dose-dependently induced gastric mucosal ulcer. Activation of NF-kappaB in the gastric mucosa corresponding to the PMA injection sites was observed before the ulcers became obvious as assessed by an in situ fluorescence DNA binding assay and electrophoretic mobility shift assay. The NF-kappaB activation and subsequent ulcer formation were significantly inhibited by injection of pyrrolidine dithiocarbamate, proteasome inhibitor (MG132), or NF-kappaB decoy. Antibody against TNF-alpha significantly inhibited ulcer formation without attenuating NF-kappaB activation. These results suggest that both NF-kappaB activation followed by TNF-alpha release contribute to tissue damage in PMA-induced gastric ulcer formation. More... »

PAGES

2070-2078

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1019633114854

DOI

http://dx.doi.org/10.1023/a:1019633114854

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052802071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12353857


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1019633114854'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1019633114854'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1019633114854'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1019633114854'


 

This table displays all metadata directly associated to this object as RDF triples.

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