Effect of Ethanol on Postprandial Duodenojejunal Motility in Humans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-08

AUTHORS

Thomas Schmidt, Roland Eberle, Albrecht Pfeiffer, Herbert Kaess

ABSTRACT

The effect of ethanol on postprandial small bowel motility was investigated in eight healthy volunteers using perfusion of nutrient solutions (17% proteins, 59% carbohydrates, 24% lipids) into the descending duodenum (5 ml/min for 120 min). An ethanol-containing solution (4% w/v, 4.06 kcal/min, 1190 mosmol/kg) was compared with the corresponding ethanol-free solution (2.64 kcal/min, 160 mosmol/kg) and another ethanol-free hyperosmolar solution adapted in caloric load and osmolality (4.06 kcal/min, 1160 mosmol/kg). Motility was recorded with a data logger and six pressure transducers at 3-cm intervals around the duodenojejunal flexure. Clustered contractions (27 +/- 4/hr) migrating aborally through the whole recording segment were the predominant motor pattern with ethanol compared with the ethanol-free (10 +/- 2/hr; P < 0.01) and the ethanol-free hyperosmolar solution (6 +/- 3/hr; P < 0.001). Other motility parameters with ethanol were not different from the ethanol-free solution, whereas the ethanol-free hyperosmolar solution showed a much less intense motor response. We conclude that ethanol does modify human postprandial duodenojejunal motility by inducing propagative motor patterns. More... »

PAGES

1628-1633

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1018892827554

DOI

http://dx.doi.org/10.1023/a:1018892827554

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023429605

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9286227


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