Increased Levels of Soluble Adhesion Molecules in the Serum of Patients with Hepatitis C (Correlation with Cytokine Concentrations and Liver ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Gilles Kaplanski, Catherine Farnarier, Marie-Josee Payan, Pierre Bongrand, Jean-Marc Durand

ABSTRACT

Lymphocyte adhesion to endothelium, extravasation, and adhesion to hepatocytes are mediated by adhesion molecules and constitute important steps in the liver inflammation due to chronic hepatitis C (HCV-CH). We measured soluble intercellular adhesion molecule (sICAM-1, sCD54), vascular cell adhesion molecule (sVCAM-1, sCD106), E-selectin (sCD62E), as well as interleukin (IL)-1 beta, IL-8, and tumor necrosis factor-alpha (TNF-alpha) concentrations in the serum of 22 patients with HCV-CH in comparison to 20 seronegative healthy volunteers. sICAM-1, sVCAM-1, sCD62E, TNF-alpha, and IL-8 but not IL-1 beta concentrations were significantly elevated in patients. sICAM-1 and sCD62E correlated with TNF-alpha and aspartate amino transferases levels. sICAM-1 correlated with liver lobular inflammation whereas sVCAM-1, sCD62E, and IL-8 correlated with liver fibrosis. Measurement of soluble adhesion molecules may be an easy way to follow liver inflammation and fibrosis during HCV-CH. More... »

PAGES

2277-2284

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1018818801824

DOI

http://dx.doi.org/10.1023/a:1018818801824

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9398806


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