Bifonazole Modulates Death of Cultured Cerebellar Granular Cells Induced by Glutamate and Oxygen-Glucose Deprivation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

E. V. Stel'mashuk, N. A. Andreeva, L. Manukhova, D. B. Zorov, N. K. Isaev

ABSTRACT

Treatment of cultured rat cerebellar granular cells with calmodulin antagonist bifonazole (10 mM) during oxygen-glucose deprivation or exposure to glutamate (75 mM) prevented neuronal death. However, addition of bifonazole after glutamate treatment promoted neuronal death. Calmodulin antagonists trifluoperazine and thioridazine had no protective effects, while thioridazine even potentiated the toxic effect of glutamate. More... »

PAGES

1076-1078

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1017920725582

DOI

http://dx.doi.org/10.1023/a:1017920725582

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038532153

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11865326


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