Porphyrins. 39. Synthesis and Chemical Transformations of Porphyrins and Chlorins with 2-Acetyl-1-methyl-3-oxobutyl Substituents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-02

AUTHORS

A. V. Reshetnickov, T. A. Babushkina, G. V. Kirillova, G. V. Ponomarev

ABSTRACT

Porphyrins and chlorins containing acetylacetone residues in the peripheral substituents [-CH(Me)CHAc2] are converted under alkaline conditions into the corresponding deacetylated compounds with [-CH(Me)CH2Ac] residues. Reduction of the latter as acids using sodium borohydride gives the corresponding alcohols and, after esterification, their acetates with branched peripheral [-CH(Me)CH2CH(OAc)Me] substituents. Porphyrins and chlorins with such substituents in water-soluble form may hold interest as new photosensitizers in photodynamic cancer therapy. More... »

PAGES

191-201

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1017563415470

DOI

http://dx.doi.org/10.1023/a:1017563415470

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024563048


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