Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal Injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-04

AUTHORS

Thomas P. Jacobs, John M. Hallenbeck, Thomas M. Devlin, Giora Z. Feuerstein

ABSTRACT

Neurological dysfunction resulting from an ischemic insult in the central nervous system (CNS) is believed to be an indirect outcome of impaired energy production. Recent studies suggest that prostaglandin Bx (PGBx), an oligomer of PGB1 and 15-keto-PGB1, may be beneficial in protecting mitochondrial function after ischemic insults by preventing uncoupling of oxidative phosphorylation. In the present study, PGBx had a significant influence on neurological outcome after ischemic injury in the rabbit spinal cord. These findings suggest that PGBx may be beneficial in the treatment of CNS ischemic injuries. More... »

PAGES

130-132

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1016466902877

DOI

http://dx.doi.org/10.1023/a:1016466902877

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039229103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3509135


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