Multiple-Dose Pharmacokinetics of Clozapine in Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-10

AUTHORS

Miles G. Choc, Robert G. Lehr, Frances Hsuan, Gilbert Honigfeld, Harold T. Smith, Richard Borison, Jan Volavka

ABSTRACT

After a 2-day buildup, patients were dosed continuously with clozapine solution at three ascending dose levels (37.5, 75, and 150 mg bid for 7 days at each dose level). Following the morning administration on the twenty-third day of dosing a drug holiday was instituted which lasted for a minimum of 48 hr. Serial plasma samples were obtained during each of the periods and during the drug holiday for the calculation of the steady-state parameters AUCSS, CSSmax, and CSSmin at each dose level as well as for the assessment of the terminal elimination rate. Mean parameter values for AUCSS, CSSmax, and CSSmin showed a linearly increasing response with the dose, well described by a straight line passing through the origin. The terminal elimination appeared to follow linear kinetics and had a mean half-life of 15.8 hr (range, 5.8-33 hr). More... »

PAGES

402-405

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1016434312388

DOI

http://dx.doi.org/10.1023/a:1016434312388

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011918113

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3508549


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